Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?

2013 ◽  
Vol 26 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Feridun Bulbul ◽  
Osman Virit ◽  
Gokay Alpak ◽  
Ahmet Unal ◽  
Mahmut Bulut ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Schizoaffective Disorder ◽  
Oxidative Metabolism ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Psychotic Symptoms ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Schizophrenic Patients

ObjectiveSchizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism.MethodsTotal oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS.ResultsTOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups.ConclusionSchizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

scholarly journals Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

Medicina ◽  
2013 ◽  
Vol 49 (3) ◽  
pp. 19 ◽  
Author(s):  
Saban Yalcin ◽  
Turgay Ulas ◽  
Mehmet Eren ◽  
Harun Aydogan ◽  
Aysun Camuzcuoglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystatin C ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Oxidative Stress Parameters ◽  
Total Antioxidant ◽  
Group 2 ◽  
Oxidant Status ◽  
Group 1

Background and Objective. Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE. Material and Methods. Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated. Results. The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001). Conclusions. The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress. Correspondence to

scholarly journals Decreased Lipid Profile and Oxidative Stress in Healthy Subjects Who Underwent Whole-Body Cryotherapy in Closed Cryochamber with Subsequent Kinesiotherapy

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Agata Stanek ◽  
Ewa Romuk ◽  
Tomasz Wielkoszyński ◽  
Stanisław Bartuś ◽  
Grzegorz Cieślar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Healthy Subjects ◽  
Whole Body ◽  
Stress Index ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Whole Body Cryotherapy ◽  
The Impact ◽  
And Oxidative Stress

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) and subsequent kinesiotherapy on oxidative stress and lipid profile when performed in a closed cryochamber on healthy subjects. Material and Methods. The effect of ten WBC procedures lasting 3 minutes a day followed by a 60-minute session kinesiotherapy on oxidative stress and lipid profile in healthy subjects (WBC group, n=16) was investigated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) and lipid profile were estimated one day before the beginning and one day after the completion of the research program. Results. After treatment, in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant capacity were observed. The activity of plasma SOD-Mn and erythrocyte total SOD increased significantly in the WBC group. In the KT group, the erythrocyte activity of total SOD, CAT, and GR decreased significantly after the treatment. The levels of T-Chol and LDL-Chol decreased significantly after treatment in both groups, but the observed decrease of these lipid parameters in the WBC group was higher in comparison to the KT group. The level of TG decreased significantly after treatment in the WBC group only. Conclusion. WBC performed in a closed cryochamber followed by kinesiotherapy improves lipid profile and decreases oxidative stress in healthy subjects.

Protective effect of adenosine triphosphate against sunitinib-related skin damage in rats

2020 ◽  
Vol 39 (12) ◽  
pp. 1737-1746
Author(s):  
N Yıldırım ◽  
A Karatas ◽  
M Cengiz ◽  
E Onalan ◽  
GN Yazıcı ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Adenosine Triphosphate ◽  
Histopathological Examination ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
The Sun ◽  
Skin Damage ◽  
Cutaneous Side Effects ◽  
Total Antioxidant

Cutaneous side effects associated with sunitinib use are a major problem in patients receiving cancer treatment. The aim of this study was to investigate the protective effect of adenosine triphosphate (ATP) against possible skin damage resulting from sunitinib use in rats. Thirty Albino Winstar rats were divided into the following three groups: healthy controls (HCs, n = 10), sunitinib (SUN, n = 10), and sunitinib + ATP (SAT, n = 10). ATP was injected intraperitoneally at a dose of 2 mg/kg. One hour subsequent to the administration of ATP and 0.9% NaCl, the SAT and SUN groups were orally administered a dose of 25 mg/kg sunitinib to the stomach. Macroscopic evaluation of the skin indicated lower levels of skin damage in the SAT group than in the SUN group. As an indicator of oxidative stress, malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels were significantly higher in the SUN group than in the HC group, while total glutathione (tGSH) and total antioxidant status (TAS) levels were significantly lower. However, MDA, TOS, and OSI levels were significantly lower in the SAT group than in the SUN group, while tGSH and TAS levels were significantly higher. Histopathological examination revealed keratin plugs with edema, vasopathology, and inflammatory cell infiltration in the SUN group. The SAT group showed less necrotic epithelium, keratin plugs, edema, and vasopathology than the SUN group. ATP can be effective in preventing skin damage caused by sunitinib use by reducing oxidative stress.

scholarly journals Önemli Tıbbi Bitkilerden Biri Olan Achillea millefolium L. (Civanperçemi) Bitkisinin Besin Elementi Konsantrasyonları ve Antioksidan Aktivitesi

2021 ◽  
Vol 9 (3) ◽  
pp. 590-594
Author(s):  
Handan Saraç ◽  
Hasan Durukan ◽  
Ahmet Demirbaş
Keyword(s):  
Oxidative Stress ◽  
Water Extract ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Achillea Millefolium ◽  
Nutrient Concentrations ◽  
Oxidative Stress Index ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

In this study, it was aimed to determine the nutrient concentrations and antioxidant activity of Achillea millefolium L. (Yarrow), which is known to have medicinal properties. For this purpose, macro and micronutrient concentrations, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of water extract Yarrow plant, which is known to be collected from Divrigi district in Sivas province, were determined. The results have shown that the yarrow plant is sufficient in terms of some macro and micronutrient concentrations, and the nitrogen (N), phosphorus (P), potassium (K), calcium (Ca) and magnesium from macro elements, iron (Fe), zinc (Zn), manganese (Mn) and copper (Cu) from micro elements concentrations were determined as 1.01% N, 0.63% P, 2.43% K, 2.22% Ca, 0.70% Mg, 360.4 mg kg-1 Fe, 47.6 mg kg-1 Zn, 85.5 mg kg-1 Mn and 28.3 mg kg-1 Cu, respectively. It has been determined that its antioxidant potential is moderate. In addition, the plant’s oxidant capacity and oxidative stress index were found to be low.

scholarly journals Elevated advanced oxidation protein products levels in patients with liver cirrhosis.

2009 ◽  
Vol 56 (4) ◽  
Author(s):  
Jolanta Zuwała-Jagiełło ◽  
Monika Pazgan-Simon ◽  
Krzysztof Simon ◽  
Maria Warwas
Keyword(s):  
Oxidative Stress ◽  
Liver Cirrhosis ◽  
Advanced Oxidation ◽  
Total Antioxidant Status ◽  
Meld Score ◽  
Stress Index ◽  
Serum Concentrations ◽  
Advanced Oxidation Protein Products ◽  
Decompensated Liver Cirrhosis ◽  
Total Antioxidant

Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.

Evaluation of the oxidative stress level and serum prolidase activity in patients with sleep bruxism

2020 ◽  
Vol 23 ◽  
Author(s):  
Ayse Ozcan-Kucuk ◽  
Bilal Ege ◽  
Mahmut Koparal ◽  
Ataman Gonel ◽  
Ismail Koyuncu
Keyword(s):  
Oxidative Stress ◽  
Stress Level ◽  
Total Antioxidant Status ◽  
Sleep Bruxism ◽  
Stress Index ◽  
Healthy Controls ◽  
Serum Samples ◽  
Prolidase Activity ◽  
Oxidative Stress Level ◽  
Total Antioxidant

Aims and Objective: Sleep bruxism is a complicated disease, and its cause remains controversial.If the aetiology of bruxism is resolved, the treatment can be adjusted to the prevailing aetiological factor.Thus,the aim of this study was to evaluate the oxidative stress level and serum prolidase activity in patients with sleep bruxism. Materials and Methods: Seventy healthy subjects and 51 patients with sleep bruxism were included in this study, and blood samples from all patients were collected. Serum samples were analysed for total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and prolidase activity. Results: The prolidase,TOS and OSI levels were significantly higher in patients with bruxism than in the healthy controls (p = 0.001, p = 0.001, p = 0.001, respectively). The TAS level was significantly lower in bruxism patientsthan in the healthy controls (p = 0.003). Conclusion: The increased TOS, OSI and prolidase levels and decreased TAS levels could be assumed to result in oxidative injury in patients with sleep bruxism. However, the study could not determine whether oxidative imbalance and increased serum prolidase levels could be a cause or a result of bruxism.

scholarly journals The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Bahanur Cekic ◽  
Sukran Geze ◽  
Gulsum Ozkan ◽  
Ahmet Besir ◽  
Mehmet Sonmez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemia Reperfusion ◽  
Total Antioxidant Status ◽  
Antioxidant Defense System ◽  
The Other ◽  
Stress Index ◽  
Total Antioxidant ◽  
The Mean ◽  
Oxidant Status ◽  
Group D

Purpose. This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats.Methods. Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum. Plasma total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) activity were measured 30 min after conclusion of pneumoperitoneum.Results. The mean TOS level was significantly higher in group P than in the other two groups, and the TOS level was significantly higher in group D than in group S (P<0.05). Plasma TAS level was found to be lower in group P than in the other two groups, and the TAS level was lower in group D than in group S (P<0.05). Consequently, the OSI was significantly higher in group P than in groups D and S (P<0.05).Conclusions. Ischemia-reperfusion phenomenon that occurs during pneumoperitoneum causes oxidative stress and consumption of plasma antioxidants. Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system.

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