scholarly journals Factors Associated with Adherence to Transdermal Nicotine Patches within a Smoking Cessation Effectiveness Trial – CORRIGENDUM

2017 ◽  
Vol 13 (3) ◽  
pp. 186-186 ◽  
Author(s):  
Jonnie Handschin ◽  
Brian Hitsman ◽  
Sonja Blazekovic ◽  
Anna Veluz-Wilkins ◽  
E. Paul Wileyto ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Online Version ◽  
Effectiveness Trial ◽  
Factors Associated ◽  
Nicotine Patches ◽  
Transdermal Nicotine

The above published article by Handschin et al. contains an error in the spelling of an author's name.Brain Hitsman, should read: Brian HitsmanThis error has now been rectified in the online version of this article.

scholarly journals Factors Associated with Adherence to Transdermal Nicotine Patches within a Smoking Cessation Effectiveness Trial

2017 ◽  
Vol 13 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Jonnie Handschin ◽  
Brian Hitsman ◽  
Sonja Blazekovic ◽  
Anna Veluz-Wilkins ◽  
E. Paul Wileyto ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Strong Predictor ◽  
Term Treatment ◽  
Anxiety Symptoms ◽  
Effectiveness Trial ◽  
Patch Use ◽  
Nicotine Patches ◽  
Transdermal Nicotine ◽  
Long Term Treatment ◽  
Over Time

Introduction: Adherence to transdermal nicotine patches, one of the most popular and effective treatments for nicotine dependence, remains very low and is a strong predictor of cessation rates.Aims: This study examined individual factors related to adherence as well as differences over time between adherent (>85% of daily patch use) and non-adherent participants (<85% of daily patch use).Methods: We analysed data from 440 participants who received 8 weeks of 21 mg transdermal nicotine and four behavioural counselling sessions within an effectiveness trial that examined the effects of long-term treatment. Multiple logistical regression assessed baseline variables associated with patch adherence and generalised estimating equations (GEE) were used to evaluate changes in craving and withdrawal, depressive and anxiety symptoms, substitute and complementary reinforcers, and side effects between participants who were or were not adherent.Results: Adherence to patch use was strongly associated with smoking cessation at week 8 (p < 0.05). In a logistic regression model, being female, living with a child or children, and higher self-reported anxiety symptoms were predictive of lower patch adherence (p < 0.05). In the GEE analysis, adherence was significantly associated with a greater reduction in craving, a greater engagement in substitute reinforcers, and a greater decrease in complementary reinforcers over time (p < 0.05).Conclusions: Difficulties adhering to transdermal nicotine patches may be related to psychiatric comorbidity, difficulty managing nicotine craving, and challenges with engaging in substitute reinforcers and reducing exposure to complementary reinforcers. These constructs may serve as targets for interventions designed to increase treatment adherence.Trial registration: ClinicalTrials.gov Identifier: NCT01047527

The influence of offering free transdermal nicotine patches on quit rates in a local health department's smoking cessation program

2004 ◽  
Vol 29 (9) ◽  
pp. 1763-1778 ◽  
Author(s):  
Anthony J. Alberg ◽  
Ruth Stashefsky Margalit ◽  
Alyce Burke ◽  
Kimberly A. Rasch ◽  
Nell Stewart ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Smoking Cessation Program ◽  
Local Health ◽  
Nicotine Patches ◽  
Transdermal Nicotine

Meta-analysis of studies investigating one-year effectiveness of transdermal nicotine patches for smoking cessation

2007 ◽  
Vol 64 (23) ◽  
pp. 2471-2476 ◽  
Author(s):  
Seung Kwon Myung ◽  
Keun-Young Yoo ◽  
Seung Won Oh ◽  
Seong Hi Park ◽  
Hong Gwan Seo ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Meta Analysis ◽  
Nicotine Patches ◽  
Transdermal Nicotine ◽  
One Year

Time and dose effect of transdermal nicotine on endothelial function

2000 ◽  
Vol 279 (4) ◽  
pp. H1913-H1921 ◽  
Author(s):  
Virginia M. Miller ◽  
W. Darrin Clouse ◽  
Britt H. Tonnessen ◽  
Umar S. Boston ◽  
Sandra R. Severson ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Isometric Force ◽  
Nicotine Patch ◽  
Calcium Ionophore ◽  
Dose Effect ◽  
Nicotine Treatment ◽  
Aortic Endothelial Cells ◽  
Nicotine Patches ◽  
Transdermal Nicotine ◽  
Counter Medication

Nicotine patches are available as an over-the-counter medication for aid in smoking cessation. This study was designed to determine how nicotine patch therapy over time and dose ranges used in smoking cessation programs in humans affects endothelium-dependent relaxations. Dogs were treated with nicotine patches (11, 22, or 44 mg/day) for 2 and 5 wk. Circulating nicotine and oxidized products of nitric oxide (NOx) were measured. Coronary arteries were prepared for measurement of isometric force and aortic endothelial cells were prepared for measurement of mRNA or NO synthase (NOS) activity. Circulating nicotine increased with increasing concentrations of nicotine patches. After 5 wk of treatment with 22 mg/day patches, circulating NOx was reduced but NOS activity was increased. NOS mRNA was similar among groups. Only after 5 wk of treatment with 22 mg/day patches were endothelium-dependent relaxations reduced to α2-adrenergic agonists, ADP, and the calcium ionophore A-23187. These results suggest a time and biphasic dose effect of nicotine treatment on endothelium-dependent responses that may be related to bioavailability of NO. This complex relationship of duration and dose of nicotine treatment may explain, in part, discrepancies in effects of nicotine on endothelium-dependent responses.

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