Stabilizing action of pressure in homogeneous compressible shear flows: effect of Mach number and perturbation obliqueness

2014 ◽  
Vol 760 ◽  
pp. 540-566 ◽  
Author(s):  
G. Kumar ◽  
Rebecca L. Bertsch ◽  
Sharath S. Girimaji
Keyword(s):  
Mach Number ◽  
High Speed ◽  
Shear Flows ◽  
Critical Role ◽  
Shear Plane ◽  
Wave Mode ◽  
Perturbation Wave ◽  
High Mach ◽  
High Level ◽  
Velocity Pressure

AbstractCompressibility exerts a stabilizing influence on a variety of high-speed shear flows such as turbulent mixing layers, transitioning boundary layers and homogeneously sheared turbulence. An important stabilizing feature that is common amongst all shear flows is the velocity–pressure interaction dynamics. In this study, velocity–pressure interactions of individual perturbation or fluctuation modes are investigated using direct numerical simulations and linear analysis in high-Mach-number homogeneous shear flow. For a given perturbation wave mode, the action of pressure is shown to depend on two important factors: the orientation of the perturbation wavevector with respect to the shear plane and the Mach number. It is shown that the streamwise perturbation wave mode rapidly develops a high level of kinetic energy but is self-limiting owing to the action of pressure. On the other hand, the energy of spanwise perturbation wave modes grows unaffected by pressure or Mach number. Oblique modes combine spanwise and streamwise characteristics and are shown to be chiefly responsible for stabilizing effects seen in shear flows. Three regimes of obliqueness of different linear stability characteristics are identified. The critical role of perturbation obliqueness on stabilization is established.

Shock phenomena in high speed aerodynamics: still a source of major concern

1999 ◽  
Vol 103 (1019) ◽  
pp. 19-34 ◽  
Author(s):  
J. M. Délery
Keyword(s):  
Mach Number ◽  
High Speed ◽  
Limiting Factor ◽  
New Techniques ◽  
Wave Patterns ◽  
Complex Wave ◽  
Real Gas Effects ◽  
High Mach ◽  
The Impact ◽  
Production Of Entropy

Abstract Shockwaves are present in a flow as soon as the Mach number becomes supersonic. Being viscous phenomena, Shockwaves are a source of drag which can be predominant when the Mach number is significantly higher than one. In supersonic air intakes, the production of entropy by shocks is felt as a loss in efficiency. At high Mach numbers, Shockwaves produce a considerable temperature rise leading to severe heating problems, complicated by real gas effects. The intersection - or interference - of two shocks gives rise to complex wave patterns containing slip-lines and associated shear layers whose impingement on a nearby surface can cause detrimental pressure and heat transfer loads. The impact of a Shockwave on a boundary layer is the origin of strong viscous interactions which remain a limiting factor in the design of transonic wings, supersonic air intakes, propulsive nozzles and compressor cascades. More effort is needed to improve prediction of these interactions and to devise new techniques to control such phenomena.

An unseeded air MHD accelerator concept for high Mach number hypersonic propulsion testing

1989 ◽  
Author(s):  
GLOYD SIMMONS ◽  
GORDON NELSON ◽  
ROBERT HIERS ◽  
ARTHURB. WESTERN
Keyword(s):  
Mach Number ◽  
Hypersonic Propulsion ◽  
High Mach Number ◽  
High Mach

Exosomal miR-214-5p Released from Glioblastoma Cells Modulates Inflammatory Response of Microglia after Lipopolysaccharide Stimulation through Targeting CXCR5

2019 ◽  
Vol 18 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Jian-kai Yang ◽  
Hong-jiang Liu ◽  
Yuanyu Wang ◽  
Chen Li ◽  
Ji-peng Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Critical Role ◽  
Luciferase Reporter ◽  
Clinical Prognosis ◽  
Direct Target ◽  
And Migration ◽  
High Level ◽  
Cxcr5 Expression ◽  
Proliferation And Migration

Background and Objective: Exosomes communicate inter-cellularly and miRNAs play critical roles in this scenario. MiR-214-5p was implicated in multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved in glioblastoma, especially via exosomal pathway, is still elusive. Here we sought to comprehensively address the critical role of exosomal miR-214-5p in glioblastoma (GBM) microenvironment.Methods:The relative expression of miR-214-5p was determined by real-time PCR. Cell viability and migration were measured by MTT and transwell chamber assays, respectively. The secretory cytokines were measured with ELISA kits. The regulatory effect of miR-214-5p on CXCR5 expression was interrogated by luciferase reporter assay. Protein level was analyzed by Western blot.Results:We demonstrated that miR-214-5p was aberrantly overexpressed in GBM and associated with poorer clinical prognosis. High level of miR-214-5p significantly contributed to cell proliferation and migration. GBM-derived exosomal miR-214-5p promoted inflammatory response in primary microglia upon lipopolysaccharide challenge. We further identified CXCR5 as the direct target of miR-214- 5p in this setting.Conclusion:Overexpression of miR-214-5p in GBM modulated the inflammatory response in microglia via exosomal transfer.

scholarly journals Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats

2021 ◽  
Vol 22 (9) ◽  
pp. 4961
Author(s):  
Maria Kovalska ◽  
Eva Baranovicova ◽  
Dagmar Kalenska ◽  
Anna Tomascova ◽  
Marian Adamkov ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Brain Area ◽  
Critical Role ◽  
Cerebrovascular Diseases ◽  
Behavioral Pattern ◽  
Cell Physiology ◽  
Male Wistar Rats ◽  
High Level ◽  
Hippocampal Alterations ◽  
The Impact

L-methionine, an essential amino acid, plays a critical role in cell physiology. High intake and/or dysregulation in methionine (Met) metabolism results in accumulation of its intermediate(s) or breakdown products in plasma, including homocysteine (Hcy). High level of Hcy in plasma, hyperhomocysteinemia (hHcy), is considered to be an independent risk factor for cerebrovascular diseases, stroke and dementias. To evoke a mild hHcy in adult male Wistar rats we used an enriched Met diet at a dose of 2 g/kg of animal weight/day in duration of 4 weeks. The study contributes to the exploration of the impact of Met enriched diet inducing mild hHcy on nervous tissue by detecting the histo-morphological, metabolomic and behavioural alterations. We found an altered plasma metabolomic profile, modified spatial and learning memory acquisition as well as remarkable histo-morphological changes such as a decrease in neurons’ vitality, alterations in the morphology of neurons in the selective vulnerable hippocampal CA 1 area of animals treated with Met enriched diet. Results of these approaches suggest that the mild hHcy alters plasma metabolome and behavioural and histo-morphological patterns in rats, likely due to the potential Met induced changes in “methylation index” of hippocampal brain area, which eventually aggravates the noxious effect of high methionine intake.

scholarly journals Enhanced Round-Robin Algorithm in the Cloud Computing Environment for Optimal Task Scheduling

Computers ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 63
Author(s):  
Fahd Alhaidari ◽  
Taghreed Zayed Balharith
Keyword(s):  
Cloud Computing ◽  
Task Scheduling ◽  
Critical Role ◽  
Turnaround Time ◽  
Round Robin ◽  
Computing Systems ◽  
Time Quantum ◽  
Dynamic Time ◽  
High Level ◽  
Level Performance

Recently, there has been significant growth in the popularity of cloud computing systems. One of the main issues in building cloud computing systems is task scheduling. It plays a critical role in achieving high-level performance and outstanding throughput by having the greatest benefit from the resources. Therefore, enhancing task scheduling algorithms will enhance the QoS, thus leading to more sustainability of cloud computing systems. This paper introduces a novel technique called the dynamic round-robin heuristic algorithm (DRRHA) by utilizing the round-robin algorithm and tuning its time quantum in a dynamic manner based on the mean of the time quantum. Moreover, we applied the remaining burst time of the task as a factor to decide the continuity of executing the task during the current round. The experimental results obtained using the CloudSim Plus tool showed that the DRRHA significantly outperformed the competition in terms of the average waiting time, turnaround time, and response time compared with several studied algorithms, including IRRVQ, dynamic time slice round-robin, improved RR, and SRDQ algorithms.

scholarly journals Aerodynamic Losses in Turbines with and without Film Cooling, as Influenced by Mainstream Turbulence, Surface Roughness, Airfoil Shape, and Mach Number

2012 ◽  
Vol 2012 ◽  
pp. 1-28 ◽  
Author(s):  
Phil Ligrani
Keyword(s):  
Surface Roughness ◽  
Mach Number ◽  
Film Cooling ◽  
Total Pressure ◽  
High Speed ◽  
Density Ratio ◽  
Aerodynamic Loss ◽  
Pressure Losses ◽  
Loss Coefficients ◽  
Exit Mach Number

The influences of a variety of different physical phenomena are described as they affect the aerodynamic performance of turbine airfoils in compressible, high-speed flows with either subsonic or transonic Mach number distributions. The presented experimental and numerically predicted results are from a series of investigations which have taken place over the past 32 years. Considered are (i) symmetric airfoils with no film cooling, (ii) symmetric airfoils with film cooling, (iii) cambered vanes with no film cooling, and (iv) cambered vanes with film cooling. When no film cooling is employed on the symmetric airfoils and cambered vanes, experimentally measured and numerically predicted variations of freestream turbulence intensity, surface roughness, exit Mach number, and airfoil camber are considered as they influence local and integrated total pressure losses, deficits of local kinetic energy, Mach number deficits, area-averaged loss coefficients, mass-averaged total pressure loss coefficients, omega loss coefficients, second law loss parameters, and distributions of integrated aerodynamic loss. Similar quantities are measured, and similar parameters are considered when film-cooling is employed on airfoil suction surfaces, along with film cooling density ratio, blowing ratio, Mach number ratio, hole orientation, hole shape, and number of rows of holes.

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