scholarly journals Lagrangian transport properties of pulmonary interfacial flows

2011 ◽  
Vol 705 ◽  
pp. 234-257 ◽  
Author(s):  
Bradford J. Smith ◽  
Sarah Lukens ◽  
Eiichiro Yamaguchi ◽  
Donald P. Gaver III
Keyword(s):  
Pulmonary Surfactant ◽  
Flow Characteristics ◽  
Fluid Phase ◽  
Convective Transport ◽  
Interfacial Flows ◽  
Lagrangian Analysis ◽  
Bulk Fluid ◽  
Free System ◽  
Micro Particle Image Velocimetry ◽  
Surfactant Transport

AbstractDisease states characterized by airway fluid occlusion and pulmonary surfactant insufficiency, such as respiratory distress syndrome, have a high mortality rate. Understanding the mechanics of airway reopening, particularly involving surfactant transport, may provide an avenue to increase patient survival via optimized mechanical ventilation waveforms. We model the occluded airway as a liquid-filled rigid tube with the fluid phase displaced by a finger of air that propagates with both mean and sinusoidal velocity components. Finite-time Lyapunov exponent (FTLE) fields are employed to analyse the convective transport characteristics, taking note of Lagrangian coherent structures (LCSs) and their effects on transport. The Lagrangian perspective of these techniques reveals flow characteristics that are not readily apparent by observing Eulerian measures. These analysis techniques are applied to surfactant-free velocity fields determined computationally, with the boundary element method, and measured experimentally with micro particle image velocimetry ($\ensuremath{\mu} $-PIV). We find that the LCS divides the fluid into two regimes, one advected upstream (into the thin residual film) and the other downstream ahead of the advancing bubble. At higher oscillatory frequencies particles originating immediately inside the LCS experience long residence times at the air–liquid interface, which may be conducive to surfactant transport. At high frequencies a well-mixed attractor region is identified; this volume of fluid cyclically travels along the interface and into the bulk fluid. The Lagrangian analysis is applied to velocity data measured with 0.01 mg ml−1 of the clinical pulmonary surfactant Infasurf in the bulk fluid, demonstrating flow field modifications with respect to the surfactant-free system that were not visible in the Eulerian frame.

Mass Transport Modelling in Porous Media Using Delay Differential Equations

2006 ◽  
Vol 258-260 ◽  
pp. 586-591
Author(s):  
António Martins ◽  
Paulo Laranjeira ◽  
Madalena Dias ◽  
José Lopes
Keyword(s):  
Porous Media ◽  
Differential Equations ◽  
Mass Transport ◽  
Delay Differential Equations ◽  
Dispersion Model ◽  
Flow Characteristics ◽  
Convective Transport ◽  
Transport Modelling ◽  
Flow Field Characteristics ◽  
Delay Differential

In this work the application of delay differential equations to the modelling of mass transport in porous media, where the convective transport of mass, is presented and discussed. The differences and advantages when compared with the Dispersion Model are highlighted. Using simplified models of the local structure of a porous media, in particular a network model made up by combining two different types of network elements, channels and chambers, the mass transport under transient conditions is described and related to the local geometrical characteristics. The delay differential equations system that describe the flow, arise from the combination of the mass balance equations for both the network elements, and after taking into account their flow characteristics. The solution is obtained using a time marching method, and the results show that the model is capable of describing the qualitative behaviour observed experimentally, allowing the analysis of the influence of the local geometrical and flow field characteristics on the mass transport.

Flow Characteristics of Pressure-Driven Water in Serpentine Micro-Channels

2006 ◽  
Author(s):  
Renqiang Xiong ◽  
J. N. Chung
Keyword(s):  
Particle Image Velocimetry ◽  
Particle Image ◽  
Flow Characteristics ◽  
Flow Structures ◽  
Micro Channel ◽  
Pressure Drops ◽  
Micro Particle Image Velocimetry ◽  
Image Velocimetry ◽  
Micro Channels ◽  
Shape And Size

Flow structures and pressure drops were investigated in rectangular serpentine micro-channels with miter bends which had hydraulic diameters of 0.209mm, 0.395mm and 0.549mm respectively. To evaluate the bend effect, the additional pressure drop due to the miter bend must be obtained. Three groups of micro-channels were fabricated to remove the inlet and outlet losses. A validated micro-particle image velocimetry (μPIV) system was used to achieve the flow structure in a serpentine micro-channel with hydraulic diameter of 0.173mm. The experimental results show the vortices around the outer and inner walls of the bend do not form when Re<100. Those vortices appear and continue to develop with the Re number when Re> 100-300, and the shape and size of the vortices almost remain constant when Re>1000. The bend loss coefficient Kb was observed to be related with the Re number when Re<100, with the Re number and channel size when Re>100. It almost keeps constant and changes in the range of ± 10% When Re is larger than some value in 1300-1500. And a size effect on Kb was also observed.

scholarly journals Effects of Selection of Inlet Perturbations, Multiphase and Turbulence Equations on Slug Flow Characteristics Using Altair® AcuSolve™

Processes ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 2152
Author(s):  
Mohammad Sobir Abdul Basith ◽  
Nabihah Sallih ◽  
William Pao King Soon ◽  
Shinji Thomas Shibano ◽  
Ramesh Singh ◽  
...  
Keyword(s):  
Level Set ◽  
Slug Flow ◽  
Fluid Dynamic ◽  
Flow Characteristics ◽  
Convective Transport ◽  
Experimental Result ◽  
Internal Boundary ◽  
Published Data ◽  
Level Set Function ◽  
Selection Of

Selection of inlet perturbations, multiphase equations, and the turbulence equation may affect the development of slug flow using computational fluid dynamic simulation tools. The inlet perturbation, such as sinusoidal and random perturbations, play an essential role in inducing slug formation. Multiphase equations such as volume of fluid and level set methods are used to track and capture the gas-liquid immiscible interface. Similarly, turbulence equations such as Spalart Allmaras (SA), Detached Eddy Simulations (DES), k-omega, and k-epsilon can be used to predict the evolution of turbulence within the flow. At present, no direct comparison is available in the literature on the selection of (i) types of inlet perturbations, (ii) the choice of multiphase equations, and (iii) the turbulence equation on the development of slug flow using the Altair computational package. This article aims to compare the effects of the selection of inlet perturbations, multiphase models and turbulence equations on slug flow characteristics using Altair® AcuSolve™. The findings by Altair® simulation were compared to published experimental data and simulation works using ANSYS and STAR-CCM+. The slug flow characteristics of interest include slug morphology, a body length-to-diameter ratio, velocity, frequency, and pressure gradient. It was found that the slug flow could be developed for all combinations of settings. Although level set approach in Altair® can track fluid motion successfully, it has a limitation in modelling the convective transport of the multiphase mixture well, unlike ANSYS and STAR-CCM+. Compared to the standard level set method, the coupling of back-and-forth error compensation and correction with the level set function helps to capture the internal boundary more accurately by reducing errors caused by numerical diffusion in the transport of the level set. It was revealed that the Spalart Allmaras turbulence equation could mimic published experimental result better than DES as it produced the closest slug translational velocity. Since the frequency of the slugs for the developed models showed a good agreement with the published data, the models could be sufficient for the investigation of fluid-structure interaction.

scholarly journals Multiphase plumes in a stratified ambient

2019 ◽  
Vol 869 ◽  
pp. 292-312 ◽  
Author(s):  
Nicola Mingotti ◽  
Andrew W. Woods
Keyword(s):  
Oil And Gas ◽  
Fluid Phase ◽  
Convective Transport ◽  
Maximum Depth ◽  
Buoyancy Flux ◽  
Return Flow ◽  
Ambient Fluid ◽  
Plume Height ◽  
Cylindrical Column ◽  
Fall Speed

We report on experiments of turbulent particle-laden plumes descending through a stratified environment. We show that provided the characteristic plume speed $(B_{0}N)^{1/4}$ exceeds the particle fall speed, where the plume buoyancy flux is $B_{0}$ and the Brunt–Väisälä frequency is $N$, then the plume is arrested by the stratification and initially intrudes at the neutral height associated with a single-phase plume of the same buoyancy flux. If the original fluid phase in the plume has density equal to that of the ambient fluid at the source, then as the particles sediment from the intruding fluid, the fluid finds itself buoyant and rises, ultimately intruding at a height of about $0.58\pm 0.03$ of the original plume height, consistent with new predictions we present based on classical plume theory. We generalise this result, and show that if the buoyancy flux at the source is composed of a fraction $F_{s}$ associated with the buoyancy of the source fluid, and a fraction $1-F_{s}$ from the particles, then following the sedimentation of the particles, the plume fluid intrudes at a height $(0.58+0.22F_{s}\pm 0.03)H_{t}$, where $H_{t}$ is the maximum plume height. This is key for predictions of the environmental impact of any material dissolved in the plume water which may originate from the particle load. We also show that the particles sediment at their fall speed through the fluid below the maximum depth of the plume as a cylindrical column whose area scales as the ratio of the particle flux at the source to the fall speed and concentration of particles in the plume at the maximum depth of the plume before it is arrested by the stratification. We demonstrate that there is negligible vertical transport of fluid in this cylindrical column, but a series of layers of high and low particle concentration develop in the column with a vertical spacing which is given by the ratio of the buoyancy of the particle load and the background buoyancy gradient. Small fluid intrusions develop at the side of the column associated with these layers, as dense parcels of particle-laden fluid convect downwards and then outward once the particles have sedimented from the fluid, with a lateral return flow drawing in ambient fluid. As a result, the pattern of particle-rich and particle-poor layers in the column gradually migrates upwards owing to the convective transport of particles between the particle-rich layers superposed on the background sedimentation. We consider the implications of the results for mixing by bubble plumes, for submarine blowouts of oil and gas and for the fate of plumes of waste particles discharged at the ocean surface during deep-sea mining.

Turbulent Flow Characteristics Over Offset Wall Confined Columns in a Channel at Low Reynolds Numbers

2018 ◽  
Author(s):  
Kira Toxopeus ◽  
Kamran Siddiqui
Keyword(s):  
Flow Characteristics ◽  
Reynolds Numbers ◽  
Turbulent Energy ◽  
Narrow Channel ◽  
Thermal Regulation ◽  
Working Fluid ◽  
Fluid Temperature ◽  
Mean Flow ◽  
Bulk Fluid ◽  
Flow Characterization

The current study is focused on the flow through offset, wall confined vertical inserts in a channel. The columns are intended to act as the thermal storage media, which continuously exchange heat with the channel fluid to regulate it thermally. These columns could, for example, be filled with a phase change material (PCM) for passive thermal regulation, or have hot or cold fluid pumped through them for active thermal regulation. The current study has two parts: (1) the flow characterization without heat transfer, and (2) flow characterization during thermal exchange with a PCM used for regulation of bulk fluid temperature. The work presented here is focused only on the first part of the study. The experiments were conducted in a narrow channel, with water as the working fluid. Two geometries of the vertical columns (circular and square) and two offset lengths were considered. For each configuration, experiments were conducted at Reynolds numbers of 20, 50 and 90 (based of the column’s characteristic length). Particle image velocimetry was used to measure the two-dimensional velocity field in a horizontal plane at multiple regions of interest along the length of the channel to characterize the flow passing over columns. The results indicate vortex shedding at the two higher Reynolds numbers. The generation, magnitude and decay rate of turbulent energy is shown to have an offset dependency at Re = 90, but a column shape dependency at Re = 50. The mean flow has a shape dependency due to the difference in separation point over the square and circular columns.

Generalizing the Theory of Microdialysis

2002 ◽  
Author(s):  
Rupak K. Banerjee ◽  
Peter M. Bungay ◽  
Malisa Sarntinoranont ◽  
Srinivas Chippada
Keyword(s):  
In Vivo Microdialysis ◽  
Convective Transport ◽  
Low Molecular Weight ◽  
Cross Sectional ◽  
Bulk Fluid ◽  
Solute Movement ◽  
Dominant Process ◽  
Hydrophilic Solutes ◽  
Probe Geometry

The efficiency of sampling or delivering solutes (analytes) by in vivo microdialysis is influenced by the diffusive permeabilities of the probe and the tissue in which the probe is implanted. In tissue, processes removing the analyte from the extracellular space are as important as diffusion in determining permeability. In addition to diffusion, analyte permeation through these media may be augmented or diminished by bulk fluid movement (transmembrane and interstitial convection). Within the perfusate, the dominant process is axial convection. Both diffusive and convective determinants of probe efficiency may be influenced by probe geometry (Figure 1; longitudinal cross-sectional view). The main geometric parameters are the probe membrane length and radii, but inner cannula geometry can also be an appreciable factor. The objective of this study is to generalize the mathematical description of microdialysis. The treatment extends in several ways previous mathematical models (Bungay et al. [1]; Morrison et al. [2]; Morrison et al. [3]; Wallgren et al. [4]). In addition to removing some simplifications and approximations and adding convective transport, the revised theory is applicable to low-molecular-weight lipophilic, as well as hydrophilic solutes. This is achieved by incorporating transcellular solute movement as a pathway paralleling interstitial diffusion. This change accompanies employing the combined intracellular and extracellular volumes, rather than the interstitial volume, as the basis for solute mass balances.

Numerical Simulation of a Contaminated Droplet by Front-Tracking Method Taking the Effect of Surfactant Transport on the Interface

2006 ◽  
Author(s):  
Yasufumi Yamamoto ◽  
Makoto Yamauchi ◽  
Tomomasa Uemura
Keyword(s):  
Silicone Oil ◽  
Water Drop ◽  
Marangoni Effect ◽  
Front Tracking ◽  
Interfacial Flows ◽  
Interfacial Transport ◽  
Front Tracking Method ◽  
Advection Diffusion Equation ◽  
Measurement Results ◽  
Surfactant Transport

In this study, a front-tracking (FT) method combined with a solver of interfacial transport of surfactant was proposed in order to resolve interfacial flows affected by contamination. In the FT method, because the interfaces are presented explicitly, advection-diffusion equation on the interface can be easily treated and can be solved highly accurately. In this study, a scheme which conserves the total amount of surfactant completely was constructed. Numerical simulations of a water drop sinking in silicone oil were performed taking the Marangoni effect into account. The effects of three parameters, a damping coefficient of interfacial tension, a diffusion coefficient and a total amount of surfactant, were evaluated. Calculated results were compared with PTV measurement results and were in very good agreement with them on the points of stagnant cap size, flow separation point, peak of shear stress and so on. So, we can expect that our simulations can estimate the conditions of surfactant on the interfaces, which is very difficult to be measured.

scholarly journals Bulk fluid phase behaviour of colloidal platelet–sphere and platelet–polymer mixtures

2013 ◽  
Vol 371 (1988) ◽  
pp. 20120259 ◽  
Author(s):  
Daniel de las Heras ◽  
Matthias Schmidt
Keyword(s):  
Phase Diagrams ◽  
Nematic Phase ◽  
Density Functional ◽  
Hard Spheres ◽  
Hard Core ◽  
Fluid Phase ◽  
Phase Behaviour ◽  
Size Ratio ◽  
Polymer Mixtures ◽  
Bulk Fluid

Using a geometry-based fundamental measure density functional theory, we calculate bulk fluid phase diagrams of colloidal mixtures of vanishingly thin hard circular platelets and hard spheres. We find isotropic–nematic phase separation, with strong broadening of the biphasic region, upon increasing the pressure. In mixtures with large size ratio of platelet and sphere diameters, there is also demixing between two nematic phases with differing platelet concentrations. We formulate a fundamental measure density functional for mixtures of colloidal platelets and freely overlapping spheres, which represent ideal polymers, and use it to obtain phase diagrams. We find that, for low platelet–polymer size ratio, in addition to isotropic–nematic and nematic–nematic phase coexistence, platelet–polymer mixtures also display isotropic–isotropic demixing. By contrast, we do not find isotropic–isotropic demixing in hard-core platelet–sphere mixtures for the size ratios considered.

scholarly journals Starfish-inspired Ultrasound Ciliary Bands for Microrobotic Systems

2021 ◽  
Author(s):  
Cornel Dillinger ◽  
Nitesh Nama ◽  
Daniel Ahmed
Keyword(s):  
Small Amplitude ◽  
Fluid Motion ◽  
Flow Characteristics ◽  
Nonlinear Acoustics ◽  
Physical Principle ◽  
Particle Manipulation ◽  
Short Hair ◽  
Bulk Fluid ◽  
Feeding Mechanism ◽  
Natural Systems

Abstract Cilia are short, hair-like appendages ubiquitous in various biological systems, which have evolved to manipulate and gather food in liquids at regimes where viscosity dominates inertia. Inspired by these natural systems, synthetic cilia have been developed and cleverly utilized in microfluidics and microrobotics to achieve functionalities such as propulsion, liquid pumping and mixing, and particle manipulation. In this article, we present the first demonstration of ultrasound-activated synthetic ciliary bands that mimic the natural arrangements of ciliary bands on the surface of starfish larva. Our system leverages nonlinear acoustics at microscales to drive bulk fluid motion via acoustically actuated small-amplitude oscillations of synthetic cilia. By arranging the planar ciliary bands angled towards (+) or away (–) from each other, we achieve bulk fluid motion akin to a flow source or sink. We further combine these flow characteristics with a novel physical principle to circumvent the scallop theorem and realize acoustic-based propulsion at microscales. Finally, inspired by the feeding mechanism of a starfish larva, we demonstrate an analogous microparticle trap by arranging + and – ciliary bands adjacent to each other.

scholarly journals Structure-based inhibitors reveal roles for the clathrin terminal domain and its W-box binding site in CME

2020 ◽  
Author(s):  
Zhiming Chen ◽  
Rosa Mino ◽  
Marcel Mettlen ◽  
Peter Michaely ◽  
Madhura Bhave ◽  
...  
Keyword(s):  
Binding Sites ◽  
Fluid Phase ◽  
Structure Design ◽  
Coated Pits ◽  
Bulk Fluid ◽  
Lysosomal Trafficking ◽  
Terminal Domain ◽  
Binding Surface ◽  
Fluid Phase Endocytosis ◽  
Late Stages

AbstractClathrin-mediated endocytosis (CME) occurs via the formation of clathrin-coated vesicles from clathrin-coated pits (CCPs). Clathrin is recruited to CCPs through interactions between the AP2 complex and its N-terminal domain (TD), which in turn recruits endocytic accessory proteins. Inhibitors of CME that interfere with clathrin function have been described, but their specificity and mechanisms of action are unclear. Here we show that overexpression of the TD with or without the distal leg specifically inhibits CME and CCP dynamics by perturbing clathrin interactions with AP2 and SNX9. We designed small membrane-penetrating peptides that mimic the four known binding sites on the TD. A peptide, Wbox2, designed to mimic to the W-box motif binding surface on TD binds to SNX9 and AP2, and potently and acutely inhibits CME, while not perturbing AP1-dependent lysosomal trafficking from the Golgi or bulk, fluid phase endocytosis.SummaryChen et al define the role the N-terminal domain (TD) of clathrin heavy chain in early and late stages of clathrin-mediated endocytosis, and guided by its structure, design a membrane-penetrating peptide, Wbox2, that acutely and potently inhibits CME.

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