scholarly journals Evaluation of Environmental Decontamination of Surfaces Using Continuous Application of Low-Level Hydrogen Peroxide

2020 ◽  
Vol 41 (S1) ◽  
pp. s227-s228
Author(s):  
Robert Garcia
Keyword(s):  
Hydrogen Peroxide ◽  
Surface Contamination ◽  
Contamination Level ◽  
Urban Hospital ◽  
Low Level ◽  
Unit Manager ◽  
Continuous Application ◽  
Bacteria And Fungi ◽  
Healthcare Associated ◽  
Humidified Air

Background: Pathogens that remain on healthcare surfaces after standard cleaning have been reported to cause 10%–30% of all healthcare-associated infections among admitted patients. The study reported here evaluated the effect of a continuous application of low-level gaseous hydrogen peroxide (H2O2) on microbial surface contamination in a pulmonary specialty unit (PSU) of a large magnet-designated urban hospital. Methods: A baseline surface contamination level was measured by obtaining cultures of 5 high-touch points in 8 patient rooms, a nurse’s station, and a nurse’s charting room to determine the bacterial and fungal microbial burden levels (period 1). No revisions to cleaning practices were made during any period. Also, 8 continuous decontamination devices were installed in the HVAC near the area to be treated. The devices convert humidified air into predominately H2O2, which then exited the ducts, covering all surfaces. Environmental sampling was conducted every 4 weeks for 4 months after activation to measure the effects on the intrinsic microbial burden on surfaces as well as the incidence of MRSA and VRE (periods 2–5). In addition, the unit manager tracked the level of absenteeism of employees in the PCU during the trial to compare results to the same 4-month period from the prior year. Results: In concert with regular cleaning and disinfecting practices, the average bacterial microbial burden levels found on 52 locations prior to the activation of the devices were 6,446 CFU/1002. Incidence of MRSA and VRE were 31% and 10%, respectively. During the intervention, the levels of both bacterial and fungal microbial burden on surfaces were significantly lower, as was the incidence of MRSA and VRE. The continuous application of low-levels of oxidizing molecules exerted a significant 78% and 97% reduction in the average bacterial and fungal microbial burden found on PSU surfaces (1,415 CFU/100 2 and 328 CFU/1002 for bacteria and fungi, respectively). The incidences of MRSA and VRE on surfaces were reduced by 63% and 70%, respectively. In addition, the unit manager reported a significant decline in absenteeism, with a reduction of 550 hours (1,313 vs 752) during the 4-month trial versus the same 4-month period the previous year. Conclusions: The introduction of continuous low-level gaseous H2O2 on all surfaces throughout a PSU reduced the overall bacterial and fungal microbial burden as well as lowered the incidence of both MRSA and VRE on surfaces, and it reduced employee absenteeism, providing a potentially safer environment for patients, staff, and visitors.Funding: NoneDisclosures: None

scholarly journals Evaluation of a Continuous Decontamination Technology in an Intensive Care Unit

2020 ◽  
Vol 41 (S1) ◽  
pp. s519-s519
Author(s):  
Tami Inman BSN ◽  
David Chansolme
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Urban Hospital ◽  
Patient Room ◽  
Colony Forming Units ◽  
Prevention Interventions ◽  
Continuous Application ◽  
Low Levels ◽  
Healthcare Associated ◽  
Cleaning And Disinfection

Background: The scientific literature increasingly indicates the need for the development of continuous disinfection to address the persistent contamination and recontamination that occurs in the patient rooms despite routine cleaning and disinfection. Methods: To determine a baseline microbial burden level on patient room surfaces in the intensive care unit (ICU) of a large urban hospital, 50 locations were swabbed for total colony-forming units (CFU) and the prevalence of methicillin-resistant Staphylococcus aureus (MRSA). Once the baseline in ICU patient rooms was established, 5 novel decontamination devices were installed in the HVAC ducts near these patient rooms. The devices provide a continuous low-level application of oxidizing molecules, predominately hydrogen peroxide. These molecules exit the duct and circulate in the patient room through normal convection, landing on all surfaces. After activation, environmental sampling was conducted every 4 weeks for 4 months. The effect from continuous low levels of oxidizing molecules on the intrinsic microbial burden and the prevalence of MRSA were analyzed. In addition to external laboratory reports, the facility tracked healthcare-associated infections (HAIs) in the unit. HAI data were averaged by month and were compared to the preactivation average in the same unit. Results: The preactivation average microbial burden found on the 50 locations were 179,000 CFU per 100 in2. The prevalence of MRSA was 71% with an average of 81 CFU per 100 in2. After activation of the devices, levels of microbial burden, prevalence of MRSA, and average monthly HAI rates were all significantly lower on average: 95% reduction in average microbial burden (8,206 CFU per 100 in2); 81% reduction in the prevalence of MRSA (13% vs 71%); 54% reduction in the average of healthcare-onset HAIs. All data were obtained from the averages of sampling data for 4 weeks during the 4-month trial period. Conclusions: The continuous application of low levels of oxidizing molecules throughout the patient rooms of an ICU demonstrated 3 outcomes: reduced overall surface microbial burden, lowered the incidence of MRSA, and significantly decreased the monthly average HAI rate. Please note, the ICU ran other infection prevention interventions at this time, including standard cleaning, as well as and their standard disinfecting techniques.Funding: This study was supported by the CASPR Group.Disclosures: None

Studies and Application of Auger Monitoring System for Quality Control and Assurance of Al Bondpads

2016 ◽  
Author(s):  
Hua Younan
Keyword(s):  
Quality Control ◽  
Sample Preparation ◽  
Monitoring System ◽  
Failure Mechanisms ◽  
Wafer Fabrication ◽  
Contamination Level ◽  
Auger Analysis ◽  
Low Level ◽  
Monitoring Frequency ◽  
Control Procedures

Abstract In wafer fabrication (Fab), Fluorine (F) based gases are used for Al bondpad opening process. Thus, even on a regular Al bondpad, there exists a low level of F contamination. However, the F level has to be controlled at a lower level. If the F level is higher than the control/spec limits, it could cause F-induced corrosion and Al-F defects, resulting in pad discoloration and NSOP problems. In our previous studies [1-5], the theories, characteristics, chemical and physical failure mechanisms and the root causes of the F-induced corrosion and Al-F defects on Al bondpads have been studied. In this paper, we further study F-induced corrosion and propose to establish an Auger monitoring system so as to monitor the F contamination level on Al bondpads in wafer fabrication. Auger monitoring frequency, sample preparation, wafer life, Auger analysis points, control/spec limits and OOC/OOS quality control procedures are also discussed.

A novel impedimetric nanobiosensor for low level determination of hydrogen peroxide based on biocatalysis of catalase

2012 ◽  
Vol 83 ◽  
pp. 31-37 ◽  
Author(s):  
Mojtaba Shamsipur ◽  
Mehdi Asgari ◽  
Mohammad Ghannadi Maragheh ◽  
Ali Akbar Moosavi-Movahedi
Keyword(s):  
Hydrogen Peroxide ◽  
Low Level

scholarly journals Disinfectant Wipes Transfer Clostridioides difficile Spores from Contaminated Surfaces to Uncontaminated Surfaces during the Disinfection Process

2020 ◽  
Author(s):  
Carine A. Nkemngong ◽  
Gurpreet K. Chaggar ◽  
Xiaobao Li ◽  
Peter J. Teska ◽  
Haley F Oliver
Keyword(s):  
Hydrogen Peroxide ◽  
Quaternary Ammonium ◽  
Healthcare Associated Infections ◽  
Cross Contamination ◽  
Healthcare Facilities ◽  
Contamination Risk ◽  
Clostridioides Difficile ◽  
Disinfection Process ◽  
The Us ◽  
Healthcare Associated

Abstract Background: Pre-wetted disinfectant wipes are increasingly being used in healthcare facilities to help address the risk of healthcare associated infections (HAI). However, HAIs are still a major problem in the US with Clostridioides difficile being the most common cause, leading to approximately 12,800 deaths annually in the US. An underexplored risk when using disinfectant wipes is that they may cross-contaminate uncontaminated surfaces during the wiping process. The objective of this study was to determine the cross-contamination risk that pre-wetted disinfectant towelettes may pose when challenged with C. difficile spores. We hypothesized that although the tested disinfectant wipes had no sporicidal claims, they will reduce spore loads. We also hypothesized that hydrogen peroxide disinfectant towelettes would present a lower cross-contamination risk than quaternary ammonium products. Methods: We evaluated the risk of cross-contamination when disinfectant wipes are challenged with C. difficile ATCC 43598 spores on Formica surfaces. A disinfectant wipe was used to wipe a Formica sheet inoculated with C. difficile. After the wiping process, we determined log10 CFU on previously uncontaminated pre-determined distances from the inoculation point and on the used wipes. Results: We found that the disinfectant wipes transferred C. difficile spores from inoculated surfaces to previously uncontaminated surfaces. We also found that wipes physically removed C. difficile spores and that hydrogen peroxide disinfectants were more sporicidal than the quaternary ammonium disinfectants. Conclusion: Regardless of the product type, all disinfectant wipes had some sporicidal effect but transferred C. difficile spores from contaminated to otherwise previously uncontaminated surfaces. Disinfectant wipes retain C. difficile spores during and after the wiping process.

Understanding ultraviolet light surface decontamination in hospital rooms: A primer

2019 ◽  
Vol 40 (9) ◽  
pp. 1030-1035 ◽  
Author(s):  
John M. Boyce ◽  
Curtis J. Donskey
Keyword(s):  
Mobile Devices ◽  
Ultraviolet Light ◽  
Surface Contamination ◽  
Healthcare Associated Infections ◽  
Healthcare Settings ◽  
Light Surface ◽  
Few Data ◽  
Healthcare Associated ◽  
Cleaning And Disinfection ◽  
Uv C

AbstractOngoing challenges in maintaining optimum manual cleaning and disinfection of hospital rooms have created increased interest in “no-touch” decontamination technologies including the use of ultraviolet light (UV). Trials have shown that some UV devices can decrease surface contamination and reduce healthcare-associated infections. Despite substantial marketing of these devices for use in healthcare settings, few data are available regarding the doses of UV-C necessary to yield desired reductions in healthcare pathogens and the ability of mobile devices to deliver adequate doses to various surfaces in patient rooms. This review summarizes the physical aspects of UV that affect the doses delivered to surfaces, the UV-C doses needed to yield 3 log10reductions of several important healthcare-associated pathogens, the doses of UV-C that can be achieved in various locations in patient rooms using mobile UV-C devices, and methods for measuring UV doses delivered to surfaces.

Acquisition and analysis of hyperspectral data for surface contamination level of insulating materials

Measurement ◽  
2020 ◽  
pp. 108560 ◽  
Author(s):  
Changjie Xia ◽  
Ming Ren ◽  
Bin Wang ◽  
Ming Dong ◽  
Bo Song ◽  
...  
Keyword(s):  
Hyperspectral Data ◽  
Surface Contamination ◽  
Contamination Level ◽  
Insulating Materials

In vitro effect of low-level laser therapy on the proliferative, apoptosis modulation, and oxi-inflammatory markers of premature-senescent hydrogen peroxide-induced dermal fibroblasts

2019 ◽  
Vol 34 (7) ◽  
pp. 1333-1343 ◽  
Author(s):  
Daíse Raquel Maldaner ◽  
Verônica Farina Azzolin ◽  
Fernanda Barbisan ◽  
Moisés Henrique Mastela ◽  
Cibele Ferreira Teixeira ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Laser Therapy ◽  
Inflammatory Markers ◽  
Dermal Fibroblasts ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Vitro Effect

Evaluation of Microbiological Contamination of Dummies used in Cardio-pulmonary Resuscitation in Korea

2020 ◽  
Vol 21 ◽  
Author(s):  
Seung-Hak Cho ◽  
Young-Seok Bak ◽  
Cheorl-Ho Kim ◽  
Jung-Beom Kim
Keyword(s):  
Survival Rate ◽  
Pathogenic Bacteria ◽  
Contamination Level ◽  
Microbiological Contamination ◽  
Biochemical Tests ◽  
Cardio Pulmonary Resuscitation ◽  
Number Of Microorganisms ◽  
Mrsa Strains ◽  
Bacteria And Fungi ◽  
Cpr Training

Objectives: In order to prevent infections through dummies used during Cardiopulmonary Resuscitation (CPR) training, we analyzed the microbiological contamination on dummies used in CPR institutions. Methods: A total of 31 dummy samples were collected from 13 different institutions in Korea, and were evaluated for the number of contaminating bacteria and fungi on the surface. PCR and biochemical tests were performed to identify pathogenic bacteria and fungi, including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, we further assessed the survival rate of microorganisms on the surface of the dummies. Results: We assessed the total number of microorganisms on the surface to be 77,752 CFU/cm2 (±50,047 CFU), which is up to 188 times higher than the requirement surface contamination level. Gram-positive cocci such as Micrococcus spp. and Staphylococcus spp. accounted for the highest proportion (55.3%). Especially, we detected three MRSA strains. Considering the isolated fungi and yeast, Aspergillus spp. and Candidia spp. accounted for the highest proportion. Assessing the contamination level simulation and survival rate on humanoid surface showed that within two weeks of training, the level of contamination on the dummy’s surface exceeded the standard, and artificially contaminated pathogenic strains on the surface of the dummy survived for at least 40 days. Conclusion: To minimize the possibility of secondary infections during CPR training, there is a requirement for a standardized protocol for proper microbiological management of dummies.

Sign in / Sign up

Export Citation Format

Share Document