scholarly journals Use of a Biological Tracer to Investigate Microbial Aerosols Generated by Heater-Cooler Units

2020 ◽  
Vol 41 (S1) ◽  
pp. s423-s423
Author(s):  
Ginny Moore ◽  
Simon Parks ◽  
Allan Bennett

Background: A multinational outbreak of Mycobacterium chimaera endocarditis following cardiac surgery has been attributed to the use of heater-cooler units (HCUs) during cardiopulmonary bypass. It is hypothesized that mycobacteria can be transmitted to the surgical site via the aerosolization of contaminated water from within the unit. In the United Kingdom, M. chimaera infections have been linked to 1 specific make and model of HCU, which was shown to generate microbial aerosols when circulating water. The manufacturer has since modified this HCU and claims that the dispersal of aerosols has now been prevented. M. chimaera is a common contaminant of HCUs, regardless of make, model, and manufacturer. To help inform local decision making, hospitals require evidence that this modified HCU and/or alternative heater-cooler systems can reduce the risk of mycobacterial infection by incorporating design features that prevent the generation of microbial aerosols external to the device. The time required to culture M. chimaera means investigations focusing on naturally or artificially contaminated HCUs are problematic. Instead, specialist aerobiological techniques incorporating a nonpathogenic, aerostable, biological tracer (Bacillus atrophaeus) were used to investigate microbial aerosols generated and released from brand-new and ‘upgraded’ HCUs. Methods: 4 HCUs (A–D), supplied directly by the manufacturers, were filled with filtered tap water, and high numbers of B. atrophaeus (109 CFU/L) were added to the tanks. High-volume cyclone samplers were used to sample the air when each HCU was switched off and during different operational phases. Samplers were operated for 5 minutes and the collecting fluid cultured for B. atrophaeus. The number of colonies was converted to CFU per cubic meter of air. Results: Under controlled experimental conditions, HCU-A released a small but significant level of aerosol during operational phases (eg, cooling) that resulted in increased pressure within the tank. The filler flap was identified as the principal area of aerosol release. The circulation of water within HCU-B and HCU-C was shown to generate an aerosol but, when connected to an ‘aerosol collection set,’ this aerosol was not released. However, it is essential that effective and sufficient vacuum is maintained. There was no aerosol release from HCU-D. Conclusions: A specialist in aerobiology using a biological tracer can determine the level of aerosol released from an HCU and its location. However, transmission of M. chimaera could occur via aerosolization of contaminated water, but it is not the only possible route of infection. The efficacy of recommended decontamination procedures must also be assured.Funding: NoneDisclosures: None

2021 ◽  
pp. 232949652110288
Author(s):  
Meaghan Stiman

In theory, participatory democracies are thought to empower citizens in local decision-making processes. However, in practice, community voice is rarely representative, and even in cases of equal representation, citizens are often disempowered through bureaucratic processes. Drawing on the case of a firearm discharge debate from a rural county’s municipal meetings in Virginia, I extend research about how power operates in participatory settings. Partisan political ideology fueled the debate amongst constituents in expected ways, wherein citizens engaged collectivist and individualist frames to sway the county municipal board ( Celinska 2007 ). However, it was a third frame that ultimately explains the ordinance’s repeal: the bureaucratic frame, an ideological orientation to participatory processes that defers decision-making to disembodied abstract rules and procedures. This frame derives its power from its depoliticization potential, allowing bureaucrats to evade contentious political debates. Whoever is best able to wield this frame not only depoliticizes the debate to gain rationalized legitimacy but can do so in such a way to favor a partisan agenda. This study advances gun research and participatory democracy research by analyzing how the bureaucratic frame, which veils partisanship, offers an alternative political possibility for elected officials, community leaders, and citizens to adjudicate partisan debates.


Health Policy ◽  
2008 ◽  
Vol 87 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Anke Richter ◽  
Katherine A. Hicks ◽  
Stephanie R. Earnshaw ◽  
Amanda A. Honeycutt

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Yushi Liu ◽  
Xiaoming Zhou ◽  
Chengbo Lv ◽  
Yingzi Yang ◽  
Tianan Liu

Fly ash (FA) has been an important ingredient for engineered cementitious composite (ECC) with excellent tensile strain capacity and multiple cracking. Unfortunately, the frost resistance of ECC with high-volume FA has always been a problem. This paper discusses the influence of silica fume (SF) and ground-granulated blast-furnace slag (GGBS) on the frost resistance of ECC with high volume of FA. Four ECC mixtures, ECC (50% FA), ECC (70% FA), ECC (30% FA + 40% SL), and ECC (65% FA + 5% SF), are evaluated by freezing-thawing cycles up to 200 cycles in tap water and sodium chloride solution. The result shows the relative dynamic elastic modulus and mass loss of ECC in sodium chloride solution by freeze-thaw cycles are larger than those in tap water by freeze-thaw cycles. Moreover, the relative dynamic elastic modulus and mass loss of ECC by freeze-thaw cycles increase with FA content increasing. However, the ECC (30% FA + 40% SL) shows a lower relative dynamic elastic modulus and mass loss, but its deflection upon four-point bending test is relatively smaller before and after freeze-thaw cycles. By contrast, the ECC (65% FA + 5% SF) exhibits a significant deflection increase with higher first cracking load, and the toughness increases sharply after freeze-thaw cycles, meaning ECC has good toughness property.


2013 ◽  
Vol 8 (1) ◽  
pp. 71-94
Author(s):  
Rolv Lyngstad

The point of departure of this article is contemporary changes in the relationship between national and local decision making in the Norwegian political system. The last decades’ centralization tendencies seem to be challenged by a “new” emphasis on local discretion, and the article discusses how this will affect social work in municipalities. The changes are contested and controversial and allude to questions such as how much discretion should be given to local decision makers in the name of local democracy, and how much difference should be accepted in the name of diversity? The article argues that professional social work must be context-specific, meaning that in a wide sense local knowledge is a prerequisite for good social work. Devolution and local political and professional discretion are necessary in many cases, but not sufficient in themselves as conditions for success. Professional social workers will encounter a lot of difficult dilemmas arousing from issues related to the equality/liberty debate and the diversity/difference/equality debate in social work discourses. In order to approach these dilemmas, more of a focus on local deliberation and place shaping, in combination with a social work focus on democratic professionalism, is necessary. If this is done successfully, devolution and a recapturing of local discretion and decision-making power will empower clients as well as professionals. Thus, current changes in the relationship between different levels of decision making will enlarge the possibilities for professional social work in the municipalities.


2014 ◽  
Vol 136 (6) ◽  
Author(s):  
Zhenghui Sha ◽  
Jitesh H. Panchal

Research in systems engineering and design is increasingly focused on complex sociotechnical systems whose structures are not directly controlled by the designers, but evolve endogenously as a result of decisions and behaviors of self-directed entities. Examples of such systems include smart electric grids, Internet, smart transportation networks, and open source product development communities. To influence the structure and performance of such systems, it is crucial to understand the local decisions that result in observed system structures. This paper presents three approaches to estimate the local behaviors and preferences in complex evolutionary systems, modeled as networks, from its structure at different time steps. The first approach is based on the generalized preferential attachment model of network evolution. In the second approach, statistical regression-based models are used to estimate the local decision-making behaviors from consecutive snapshots of the system structure. In the third approach, the entities are modeled as rational decision-making agents who make linking decisions based on the maximization of their payoffs. Within the decision-centric framework, the multinomial logit choice model is adopted to estimate the preferences of decision-making nodes. The approaches are illustrated and compared using an example of the autonomous system (AS) level Internet. The approaches are generally applicable to a variety of complex systems that can be modeled as networks. The insights gained are expected to direct researchers in choosing the most applicable estimation approach to get the node-level behaviors in the context of different scenarios.


Geophysics ◽  
2021 ◽  
pp. 1-38
Author(s):  
Timothy Larson ◽  
Zuze Dulanya ◽  
Evance Mwathunga

Choosing the site for a new water well in rural southern Malawi is essentially a political process with competing priorities and stakeholders. For a new well (or borehole) to be sustainably used and maintained, the relevant stakeholders must be fully engaged in the siting process and given meaningful responsibility for the final siting decision. However, without sound technical information, a siting decision based solely on stakeholder priorities such as proximity to the headman’s compound or accessibility to the center of population, may not result in a satisfactory borehole. Instead, in addition to stakeholder interests, we used a process that includes electrical resistivity tomography (ERT) as a tool to guide and constrain the local decision-making process. Within the region of the crystalline-basement aquifer, ERT profiles indicate variations in weathering thickness, hence aquifer storage. In a lacustrine setting, the ERT profile delineated a zone of moderately large resistivity associated with a deposit of fresh-water saturated sand. This ERT-derived technical information becomes one element in a comprehensive sociotechnical approach to the location of sustainable water resources. We used this sociotechnical approach to complete boreholes for all four villages in our project and have a high confidence that the villagers will be motivated to use and maintain these resources.


Chemosphere ◽  
2019 ◽  
Vol 231 ◽  
pp. 502-509 ◽  
Author(s):  
Eriko Yamazaki ◽  
Sachi Taniyasu ◽  
Kosuke Noborio ◽  
Heesoo Eun ◽  
Pooja Thaker ◽  
...  

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