Pseudo-outbreak of Mycobacterium chimaera through aerators of hand-washing machines at a hematopoietic stem cell transplantation center

2019 ◽  
Vol 40 (12) ◽  
pp. 1433-1435 ◽  
Author(s):  
Shingen Nakamura ◽  
Momoyo Azuma ◽  
Masami Sato ◽  
Noriko Fujiwara ◽  
Saori Nishino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Biofilm Formation ◽  
Hand Washing ◽  
Hematopoietic Stem ◽  
Washing Machines ◽  
Transplantation Center

AbstractWe identified a waterborne pseudo-outbreak of Mycobacterium chimaera in our stem cell transplantation center, which likely resulted from biofilm on the aerators of the handwashing machines in each patient’s room. Regular replacement of faucet parts can prevent biofilm formation and pseudo-outbreaks of M. chimaera through aerators.

scholarly journals The start-up of the first hematopoietic stem cell transplantation center in the Iraqi Kurdistan: a capacity-building cooperative project by the Hiwa Cancer Hospital, Sulaymaniyah, and the Italian Agency for Development Cooperation.

2017 ◽  
Vol 9 (1) ◽  
pp. e2017031 ◽  
Author(s):  
Ignazio Majolino
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Capacity Building ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Development Cooperation ◽  
Hematopoietic Stem ◽  
Start Up ◽  
Transplantation Center

We describe the entire process leading to the start-up of an hematopoietic stem cell transplantation center at the Hiwa Cancer Hospital, in the city of Sulaymaniyah, Kurdistan Iraqi Region. This capacity building project was funded by the Italian Agency for Development Cooperation, and implemented with the support of the volunteer work of Italian professionals, either physicians, nurses, biologists and technicians. The intervention started in April 2016, was based exclusively on training and coaching, and led to a first autologous transplantation in June 2016 and to an allogeneic transplantation in October. At the time of reporting, 9 months from the initiation of the project, 18 patients have been transplanted, 15with an autologous and 3 with an allogeneic graft. The center at the HCH represents the first transplantation center in Kurdistan and the second in wide Iraq. We conclude that international development cooperation may play an important role also in the field of high-technology medicine, and contribute to improved local centers capabilities through country to country scientific exchanges.

scholarly journals Evolution of vancomycin-resistantEnterococcus faeciumduring colonization and infection in immunocompromised pediatric patients

2020 ◽  
Vol 117 (21) ◽  
pp. 11703-11714 ◽  
Author(s):  
Gayatri Shankar Chilambi ◽  
Hayley R. Nordstrom ◽  
Daniel R. Evans ◽  
Jose A. Ferrolino ◽  
Randall T. Hayden ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Bloodstream Infection ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Biofilm Formation ◽  
Pediatric Patients ◽  
Patient Specific ◽  
Hematopoietic Stem

Patients with hematological malignancies or undergoing hematopoietic stem cell transplantation are vulnerable to colonization and infection with multidrug-resistant organisms, including vancomycin-resistantEnterococcus faecium(VREfm). Over a 10-y period, we collected and sequenced the genomes of 110 VREfm isolates from gastrointestinal and blood cultures of 24 pediatric patients undergoing chemotherapy or hematopoietic stem cell transplantation for hematological malignancy at St. Jude Children’s Research Hospital. We used patient-specific reference genomes to identify variants that arose over time in subsequent gastrointestinal and blood isolates from each patient and analyzed these variants for insight into how VREfm adapted during colonization and bloodstream infection within each patient. Variants were enriched in genes involved in carbohydrate metabolism, and phenotypic analysis identified associated differences in carbohydrate utilization among isolates. In particular, a Y585C mutation in the sorbitol operon transcriptional regulatorgutRwas associated with increased bacterial growth in the presence of sorbitol. We also found differences in biofilm-formation capability between isolates and observed that increased biofilm formation correlated with mutations in the putativeE. faeciumcapsular polysaccharide (cps) biosynthetic locus, with different mutations arising independently in distinct genetic backgrounds. Isolates withcpsmutations showed improved survival following exposure to lysozyme, suggesting a possible reason for the selection of capsule-lacking bacteria. Finally, we observed mutations conferring increased tolerance of linezolid and daptomycin in patients who were treated with these antibiotics. Overall, this study documents known and previously undescribed ways that VREfm evolve during intestinal colonization and subsequent bloodstream infection in immunocompromised pediatric patients.

Caregiver perspectives on psychosocial care in pediatric hematopoietic stem cell transplantation (HCT).

2020 ◽  
Vol 8 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Anne E. Kazak ◽  
Avi Madan Swain ◽  
Ahna L. H. Pai ◽  
Kimberly Canter ◽  
Olivia Carlson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Psychosocial Care ◽  
Hematopoietic Stem
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