High rate of linezolid intermediate susceptibility and resistance among enteric vancomycin-resistant Enterococcus (VRE) recovered from hospitalized patients actively screened for VRE colonization

2019 ◽  
Vol 40 (7) ◽  
pp. 821-822 ◽  
Author(s):  
Thomas J. Dilworth ◽  
Eric T. Beck ◽  
Rachel A. Pedersen ◽  
Waseem G. Al-Karkokly ◽  
Margaret M. Cook ◽  
...  
Keyword(s):  
Hospitalized Patients ◽  
High Rate ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant ◽  
Susceptibility And Resistance

Undetected Vancomycin-Resistant Enterococcus in Surgical Intensive Care Unit Patients

1999 ◽  
Vol 20 (10) ◽  
pp. 685-686 ◽  
Author(s):  
Richard A. Zuckerman ◽  
Lynn Steele ◽  
Richard A. Venezia ◽  
Ellis H. Tobin
Keyword(s):  
Active Surveillance ◽  
High Rate ◽  
Surgical Intensive Care Unit ◽  
High Risk Population ◽  
Vancomycin Resistant Enterococcus ◽  
Surgical Intensive Care ◽  
Total Cost ◽  
Additional Costs ◽  
Surveillance Method ◽  
Vancomycin Resistant

AbstractThe rates of vancomycin-resistant Enterococcus (VRE) in a high-risk population were investigated prospectively using an active surveillance method. The costs of conducting active surveillance were calculated. Among the 10 patients found to have VRE, routine cultures identified 3 (30%); thus, 70% of the VRE-colonized patients would have gone undetected in the absence of active surveillance. The total cost for 5 weeks of active surveillance was $2,234. Although active surveillance identified a high rate of VRE-colonized patients who otherwise may not have been identified, it remains to be determined if the additional costs are justified and result in reduced transmission.

Risk factors for vancomycin-resistant Enterococcus faecalis bacteremia in hospitalized patients: An analysis of two case-control studies

2006 ◽  
Vol 34 (7) ◽  
pp. 447-451 ◽  
Author(s):  
Guilherme Henrique Campos Furtado ◽  
Rodrigo Elisandro Mendes ◽  
Antônio Carlos Campos Pignatari ◽  
Sérgio Barsanti Wey ◽  
Eduardo Alexandrino Servolo Medeiros
Keyword(s):  
Risk Factors ◽  
Enterococcus Faecalis ◽  
Case Control ◽  
Hospitalized Patients ◽  
Vancomycin Resistant Enterococcus ◽  
Case Control Studies ◽  
Vancomycin Resistant

scholarly journals Gut microbiota predict Enterococcus expansion but not Vancomycin-resistant Enterococcus acquisition

2020 ◽  
Author(s):  
Rishi Chanderraj ◽  
Christopher A. Brown ◽  
Kevin Hinkle ◽  
Nicole Falkowski ◽  
Piyush Ranjan ◽  
...  
Keyword(s):  
At Risk ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Case Control ◽  
Hospitalized Patients ◽  
Vancomycin Resistant Enterococcus ◽  
Control Subjects ◽  
Matched Case ◽  
Vancomycin Resistant ◽  
And Control

ABSTRACTBACKGROUNDVancomycin-resistant Enterococcus (VRE) is a leading cause of hospital-acquired infections, and continues to spread despite widespread implementation of pathogen-targeted control guidelines. Commensal gut microbiota provide colonization resistance to VRE, but the role of gut microbiota in VRE acquisition in at-risk patients is unknown.METHODSWe performed a case-control study of gut microbiota in hospitalized patients who did (cases) and did not (controls) acquire VRE. We matched case subjects to control subjects by known risk factors and “time at risk,” defined as the time elapsed between admission until positive VRE screen. We characterized gut bacterial communities using 16S rRNA gene amplicon sequencing of rectal swab specimens.RESULTSWe analyzed 236 samples from 59 matched case-control pairs. At baseline, case and control subjects did not differ in gut microbiota when measured by community diversity (p=0.33) or composition (p=0.30). After hospitalization, gut communities of cases and controls differed only in the abundance of the Enterococcus containing operational taxonomic unit (OTU), with the gut microbiota of case subjects having more of this OTU than time-matched control subjects (p=0.01). Otherwise, case and control communities after the time at risk did not differ in diversity (p=.33) or community structure (p=0.12). Among patients who became VRE colonized, those having the Blautia containing OTU on admission had lower Enterococcus relative abundance once colonized (p =0.004).CONCLUSIONSThe 16S profile of the gut microbiome does not predict VRE acquisition in hospitalized patients, likely due to rapid and profound microbiota change. The gut microbiome does not predict VRE acquisition, but may be associated with Enterococcus expansion, suggesting that these should be considered as two distinct processes.Summary16S profile of the gut microbiome does not predict VRE acquisition in hospitalized patients, likely due to the rapid and profound microbiota change in this) opulation. VRE expansion and VRE acquisition may be two distinct processes.

GASTROINTESTINAL COLONISATION OF VANCOMYCIN-RESISTANT ENTEROCOCCUS IN A SINGAPORE TEACHING HOSPITAL

Pathology ◽  
2001 ◽  
Vol 33 (2) ◽  
pp. 216-221
Author(s):  
Lynette L. E. Oon ◽  
Moi-Lin Ling ◽  
Yoke-Fong Chiew
Keyword(s):  
Teaching Hospital ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant
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