scholarly journals Menacing Emergence of Fosfomycin Resistance Among Klebsiella pneumoniae Carbapenemase–2-Producing K. pneumoniae Driven by Prior Use in Critically Ill Patients

2016 ◽  
Vol 37 (6) ◽  
pp. 748-749 ◽  
Author(s):  
Leandro Reus Rodrigues Perez
Keyword(s):  
Klebsiella Pneumoniae ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Klebsiella Pneumoniae Carbapenemase ◽  
Prior Use ◽  
Fosfomycin Resistance

scholarly journals Mortality of Pandrug-Resistant Klebsiella pneumoniae Bloodstream Infections in Critically Ill Patients: A Retrospective Cohort of 115 Episodes

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 76
Author(s):  
Matthaios Papadimitriou-Olivgeris ◽  
Christina Bartzavali ◽  
Alexandra Georgakopoulou ◽  
Fevronia Kolonitsiou ◽  
Chrisavgi Papamichail ◽  
...  
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Primary Outcome ◽  
Bloodstream Infections ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Carbapenemase Gene ◽  
Comorbidity Index

Background: The increased frequency of bacteraemias caused by pandrug-resistant Klebsiella pneumoniae (PDR-Kp) has significant implications. The aim of the present study was to identify predictors associated with mortality of PDR-Kp bacteraemias. Methods: Patients with monomicrobial bacteraemia due to PDR-Kp were included. K. pneumoniae was considered PDR if it showed resistance to all available groups of antibiotics. Primary outcome was 30-day mortality. Minimum inhibitory concentrations (MICs) of meropenem, tigecycline, fosfomycin, and ceftazidime/avibactam were determined by Etest, whereas for colistin, the broth microdilution method was applied. blaKPC, blaVIM, blaNDM, and blaOXA genes were detected by PCR. Results: Among 115 PDR-Kp bacteraemias, the majority of infections were primary bacteraemias (53; 46.1%), followed by catheter-related (35; 30.4%). All isolates were resistant to tested antimicrobials. blaKPC was the most prevalent carbapenemase gene (98 isolates; 85.2%). Thirty-day mortality was 39.1%; among 51 patients with septic shock, 30-day mortality was 54.9%. Multivariate analysis identified the development of septic shock, Charlson comorbidity index, and bacteraemia other than primary or catheter-related as independent predictors of mortality, while a combination of at least three antimicrobials was identified as an independent predictor of survival. Conclusions: Mortality of PDR-Kp bloodstream infections was high. Administration of at least three antimicrobials might be beneficial for infections in critically ill patients caused by such pathogens.

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis

2017 ◽  
Vol 45 (3) ◽  
pp. 454-463 ◽  
Author(s):  
Maryse A. Wiewel ◽  
Lonneke A. van Vught ◽  
Brendon P. Scicluna ◽  
Arie J. Hoogendijk ◽  
Jos F. Frencken ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Critically Ill ◽  
Calcium Channel Blockers ◽  
Critically Ill Patients ◽  
Channel Blockers ◽  
Prior Use

The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients

Infection ◽  
2014 ◽  
Vol 42 (5) ◽  
pp. 883-890 ◽  
Author(s):  
M. Papadimitriou-Olivgeris ◽  
M. Christofidou ◽  
F. Fligou ◽  
C. Bartzavali ◽  
T. Vrettos ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Colonization Pressure

Tigecycline therapy for infections due to carbapenemase-producing Klebsiella pneumoniae in critically ill patients

2013 ◽  
Vol 46 (3) ◽  
pp. 175-180 ◽  
Author(s):  
B. Balandin Moreno ◽  
I. Fernández Simón ◽  
V. Pintado García ◽  
I. Sánchez Romero ◽  
B. Isidoro Fernández ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Critically Ill ◽  
Critically Ill Patients

scholarly journals Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Jesus Ruiz ◽  
Monica Gordon ◽  
Esther Villarreal ◽  
Juan Frasquet ◽  
María Ángeles Sánchez ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Drug Resistant
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