Guideline-Concordant Versus Discordant Antimicrobial Therapy in Patients With Community-Onset Complicated Intra-abdominal Infections

2016 ◽  
Vol 37 (7) ◽  
pp. 855-858 ◽  
Author(s):  
Lori L. Huang ◽  
Trevor C. Van Schooneveld ◽  
Robert D. Huang ◽  
Keith M. Olsen ◽  
Mark E. Rupp ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Empiric Therapy ◽  
Infect Control Hosp ◽  
Active Therapy ◽  
Abdominal Infection ◽  
Guideline Compliance ◽  
Improved Outcomes ◽  
Intra Abdominal Infection ◽  
Abdominal Infections ◽  
Community Onset

Overall IDSA/SIS intra-abdominal infection guideline compliance was not associated with improved outcomes; however, there was a longer time to active therapy (P=.024) and higher mortality (P=.077) if empiric therapy was too narrow per guidelines. These findings support the need for the implementation of customized institutional guidelines adapted from the IDSA/SIS guidelines.Infect Control Hosp Epidemiol 2016;37:855–858

scholarly journals Antibiotic susceptibility of intra-abdominal infection isolates from Indian hospitals during 2008

2010 ◽  
Vol 59 (9) ◽  
pp. 1050-1054 ◽  
Author(s):  
Stephen P. Hawser ◽  
Robert E. Badal ◽  
Samuel K. Bouchillon ◽  
Daryl J. Hoban ◽  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Resistance ◽  
Gram Negative ◽  
E Coli ◽  
Abdominal Infection ◽  
Intra Abdominal Infection ◽  
Abdominal Infections ◽  
Hospital Acquired ◽  
Very High

A total of 542 clinical isolates of aerobic Gram-negative bacilli from intra-abdominal infections were collected during 2008 from seven hospitals in India participating in the Study for Monitoring Antimicrobial Resistance Trends (SMART). Isolates were from various infection sources, the most common being gall bladder (30.1 %) and peritoneal fluid (31.5 %), and were mostly hospital-associated isolates (70.8 %) as compared to community-acquired (26.9 %). The most frequently isolated pathogens were Escherichia coli (62.7 %), Klebsiella pneumoniae (16.7 %) and Pseudomonas aeruginosa (5.3 %). Extended-spectrum β-lactamase (ESBL) rates in E. coli and K. pneumoniae were very high, at 67 % and 55 %, respectively. Most isolates exhibited resistance to one or more antibiotics. The most active drugs were generally ertapenem, imipenem and amikacin. However, hospital-acquired isolates in general, as well as ESBL-positive isolates, exhibited lower susceptibilities than community-acquired isolates. Further surveillance monitoring of intra-abdominal isolates from India is recommended.

scholarly journals Outcome of Community- versus Hospital-Acquired Intra-Abdominal Infections in Intensive Care Unit: a Retrospective Study

2020 ◽  
Author(s):  
Timothée Abaziou ◽  
Fanny Vardon-Bounes ◽  
Jean-Marie Conil ◽  
Antoine Rouget ◽  
Stéphanie Ruiz ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Retrospective Study ◽  
Mortality Rate ◽  
Apache Ii Score ◽  
Abdominal Infection ◽  
Hospital Stays ◽  
Intra Abdominal Infection ◽  
Abdominal Infections ◽  
Hospital Acquired

Abstract Background: To compare patients hospitalised in the intensive care unit (ICU) after surgery for community-acquired intra-abdominal infection (CA-IAI) and hospital-acquired intra-abdominal infection (HA-IAI) in terms of mortality, severity and complications.Methods: Retrospective study including all patients admitted to 2 ICUs within 48 hours of undergoing surgery for peritonitis.Results: 226 patients were enrolled during the study period. Patients with CA-IAI had an increased 28-day mortality rate compared to those with HA-IAI (30% vs 15%, respectively (p = 0.009)). At 90 days, the mortality rates were 36.7% and 37.5% in the CA-IAI group and HA-IAI group, respectively, with a similar APACHE II score on admission (median: 21 [15 – 25] vs. 21 [15 - 24] respectively, p = 0.63). The patients with HA-IAI had prolonged ICU and hospital stays (median: 17 [7 – 36] vs. 6[3 – 12] days, p < 0.001 and 41 [24 – 66] vs. 17 [7 – 32] days, p = 0.001), and experienced more complications (reoperation and reintubation) than those with CA-IAI. Conclusion: CA-IAI group had higher 28-day mortality rate than HA IAI group. Mortality was similar at 90 days but those with HA-IAI had a prolonged ICU and hospital stay. In addition, they developed more complications.

scholarly journals Outcome of community- versus hospital-acquired intra-abdominal infections in intensive care unit: a retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Timothée Abaziou ◽  
Fanny Vardon-Bounes ◽  
Jean-Marie Conil ◽  
Antoine Rouget ◽  
Stéphanie Ruiz ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Retrospective Study ◽  
Mortality Rate ◽  
Apache Ii Score ◽  
Abdominal Infection ◽  
Hospital Stays ◽  
Intra Abdominal Infection ◽  
Abdominal Infections ◽  
Hospital Acquired

Abstract Background To compare patients hospitalised in the intensive care unit (ICU) after surgery for community-acquired intra-abdominal infection (CA-IAI) and hospital-acquired intra-abdominal infection (HA-IAI) in terms of mortality, severity and complications. Methods Retrospective study including all patients admitted to 2 ICUs within 48 h of undergoing surgery for peritonitis. Results Two hundred twenty-six patients were enrolled during the study period. Patients with CA-IAI had an increased 28-day mortality rate compared to those with HA-IAI (30% vs 15%, respectively (p = 0.009)). At 90 days, the mortality rates were 36.7 and 37.5% in the CA-IAI group and HA-IAI group, respectively, with a similar APACHE II score on admission (median: 21 [15–25] vs. 21 [15–24] respectively, p = 0.63). The patients with HA-IAI had prolonged ICU and hospital stays (median: 17 [7–36] vs. 6[3–12] days, p < 0.001 and 41 [24–66] vs. 17 [7–32] days, p = 0.001), and experienced more complications (reoperation and reintubation) than those with CA-IAI. Conclusion CA-IAI group had higher 28-day mortality rate than HA-IAI group. Mortality was similar at 90 days but those with HA-IAI had a prolonged ICU and hospital stay. In addition, they developed more complications.

Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy

2016 ◽  
Vol 222 (4) ◽  
pp. 440-446 ◽  
Author(s):  
Rishi Rattan ◽  
Casey J. Allen ◽  
Robert G. Sawyer ◽  
Reza Askari ◽  
Kaysie L. Banton ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Abdominal Infection ◽  
Intra Abdominal Infection

Short-Course Antimicrobial Therapy Does Not Increase Treatment Failure Rate in Patients with Intra-Abdominal Infection Involving Fungal Organisms

2018 ◽  
Vol 19 (4) ◽  
pp. 376-381 ◽  
Author(s):  
Nathan R. Elwood ◽  
Christopher A. Guidry ◽  
Therese M. Duane ◽  
Joseph Cuschieri ◽  
Charles H. Cook ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Failure Rate ◽  
Antimicrobial Therapy ◽  
Abdominal Infection ◽  
Short Course ◽  
Treatment Failure Rate ◽  
Fungal Organisms ◽  
Intra Abdominal Infection

scholarly journals Outcome of Community- Versus Hospital-Acquired Intra-Abdominal Infections in Intensive Care Unit: a Retrospective Study

2020 ◽  
Author(s):  
Timothée Abaziou ◽  
Fanny Vardon-Bounes ◽  
Jean-Marie Conil ◽  
Antoine Rouget ◽  
Stéphanie Ruiz ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Mortality Rate ◽  
Mortality Rates ◽  
Apache Ii Score ◽  
Abdominal Infection ◽  
Hospital Stays ◽  
Intra Abdominal Infection ◽  
Abdominal Infections ◽  
Hospital Acquired

Abstract BackgroundTo compare patients hospitalised in the intensive care unit (ICU) after surgery for community-acquired intra-abdominal infection (CA-IAI) and hospital-acquired intra-abdominal infection (HA-IAI) in terms of mortality, severity and complications.MethodsRetrospective study including all patients admitted to 2 ICUs within 48 hours of undergoing surgery for peritonitis.Results226 patients were enrolled during the study period. Patients with CA-IAI had an increased 28-day mortality rate compared to those with HA-IAI (30% vs 15%, respectively (p = 0.009)). At 90 days, the mortality rates were 36.7% and 37.5% in the CA-IAI group and HA_IAI group, respectively, with a similar APACHE II score on admission (median: 21 [15–25] vs. 21 [15–24] respectively, p = 0.63). The patients with HA-IAI had prolonged ICU and hospital stays (median: 17 [7–36] vs. 6[3–12] days, p < 0.001 and 41 [24–66] vs. 17 [7–32] days, p = 0.001), and experienced more complications (reoperation and reintubation) than those with CAP.ConclusionCA-IAI group had higher 28-day mortality rate than HA IAI group. Mortality was similar at 90 days but those with HAP had a prolonged ICU and hospital stay. In addition, they developed more complications.

Sign in / Sign up

Export Citation Format

Share Document