Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring

2016 ◽  
Vol 38 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Claire Wintenberger ◽  
Daniele Maubon ◽  
Elena Charpentier ◽  
John Rendu ◽  
Patricia Pavese ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Case Series ◽  
Epidemiological Survey ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

OBJECTIVETo determine the origin of grouped cases of Pneumocystis pneumonia in solid-organ transplant recipients at our institution.DESIGNA case series with clinical examinations, genotyping, and an epidemiological survey.SETTINGA university hospital in France.PATIENTSWe report 12 solid-organ transplant recipients with successive cases of Pneumocystis pneumonia that occurred over 3 years; 10 of these cases occurred in a single year.METHODSWe used molecular typing of P. jirovecii strains by multilocus sequence typing and clinical epidemiological survey to determine potential dates and places of transmission.RESULTSBetween May 2014 and March 2015, 10 solid-organ transplant recipients (5 kidney transplants, 4 heart transplants, and 1 lung transplant) presented with Pneumocystis pneumonia. Molecular genotyping revealed the same P. jirovecii strain in at least 6 patients. This Pneumocystis strain was not identified in control patients (ie, nontransplant patients presenting with pulmonary pneumocystosis) during this period. The epidemiological survey guided by sequencing results provided information on the probable or possible dates and places of contamination for 5 of these patients. The mobile infectious diseases unit played a coordination role in the clinical management (adaptation of the local guidelines) and epidemiological survey.CONCLUSIONOur cardiac and kidney transplant units experienced grouped cases of pulmonary pneumocystosis. Genotyping and epidemiological surveying results suggested interhuman contamination, which was quickly eliminated thanks to multidisciplinary coordination.Infect Control Hosp Epidemiol 2017;38:179–185

scholarly journals Viral Enteritis in Solid-Organ Transplantation

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2019
Author(s):  
Anum Abbas ◽  
Andrea J. Zimmer ◽  
Diana Florescu
Keyword(s):  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Post Transplantation ◽  
Organ Transplant Recipients ◽  
Increased Risk ◽  
Viral Enteritis ◽  
Solid Organ Transplant Recipients

Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation, with infectious causes of diarrhea being a frequent complication. Viral infections/enteritides in solid organ transplant recipients often result from frequently encountered pathogens in this population such as cytomegalovirus, adenovirus, and norovirus. However, several emerging viral pathogens are increasingly being recognized as more sensitive diagnostic techniques become available. Treatment is often limited to supportive care and reduction in immunosuppression, though antiviral therapies mayplay a role in the treatment in certain diseases. Viral enteritis is an important entity that contributes to morbidity and mortality in transplant recipients.

scholarly journals COVID‐19 in solid organ transplant recipients: A single‐center case series from Spain

2020 ◽  
Vol 20 (7) ◽  
pp. 1849-1858 ◽  
Author(s):  
Mario Fernández‐Ruiz ◽  
Amado Andrés ◽  
Carmelo Loinaz ◽  
Juan F. Delgado ◽  
Francisco López‐Medrano ◽  
...  
Keyword(s):  
Organ Transplant ◽  
Case Series ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Single Center ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

scholarly journals Challenges in the Diagnosis and Management of Bacterial Lung Infections in Solid Organ Recipients: A Narrative Review

2020 ◽  
Vol 21 (4) ◽  
pp. 1221 ◽  
Author(s):  
Manuela Carugati ◽  
Letizia Morlacchi ◽  
Anna Peri ◽  
Laura Alagna ◽  
Valeria Rossetti ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Narrative Review ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Diagnosis And Management ◽  
Solid Organ Transplant Recipients

Respiratory infections pose a significant threat to the success of solid organ transplantation, and the diagnosis and management of these infections are challenging. The current narrative review addressed some of these challenges, based on evidence from the literature published in the last 20 years. Specifically, we focused our attention on (i) the obstacles to an etiologic diagnosis of respiratory infections among solid organ transplant recipients, (ii) the management of bacterial respiratory infections in an era characterized by increased antimicrobial resistance, and (iii) the development of antimicrobial stewardship programs dedicated to solid organ transplant recipients.

scholarly journals Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients

2019 ◽  
Vol 45 (5) ◽  
pp. 573-591 ◽  
Author(s):  
Jean-François Timsit ◽  
Romain Sonneville ◽  
Andre C. Kalil ◽  
Matteo Bassetti ◽  
Ricard Ferrer ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Therapeutic Approach ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients
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