scholarly journals Low Incidence of Central Venous Catheter–Related Bloodstream Infections in Stem Cell Transplant Patients in Eastern India Despite High Community Burden of Multidrug-Resistant Pathogens

2016 ◽  
Vol 37 (5) ◽  
pp. 619-620 ◽  
Author(s):  
Mita Roychowdhury ◽  
Jeevan Kumar ◽  
Anupam Chakrapani ◽  
Saurabh Jayant Bhave ◽  
Shekhar Krishnan ◽  
...  
Keyword(s):  
Stem Cell Transplant ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
Multidrug Resistant ◽  
Cell Transplant ◽  
Eastern India ◽  
Central Venous ◽  
Transplant Patients ◽  
Multidrug Resistant Pathogens ◽  
Low Incidence

A Retrospective Analysis of Bloodstream Infections in Pediatric Allogeneic Stem Cell Transplant Recipients: The Role of Central Venous Catheters and Mucosal Barrier Injury

2018 ◽  
Vol 35 (3) ◽  
pp. 210-217 ◽  
Author(s):  
Chelsea Balian ◽  
Michelle Garcia ◽  
Jessica Ward
Keyword(s):  
Stem Cell ◽  
Retrospective Analysis ◽  
Stem Cell Transplant ◽  
Bloodstream Infections ◽  
Central Venous Catheters ◽  
Mucosal Barrier ◽  
Cell Transplant ◽  
Central Venous ◽  
Mucosal Barrier Injury ◽  
Pathogenic Organisms

Background: Bloodstream infections (BSIs) are a leading cause of morbidity and mortality in children undergoing hematopoietic stem cell transplant (HSCT). Indwelling central venous catheters (CVCs) increase risk for BSIs, yet mucosal barrier injury–associated laboratory-confirmed bloodstream infection (MBI-LCBI) may also occur due to translocation of pathogenic organisms from the gastrointestinal tract into the bloodstream. The purpose of this study was to determine the association between stool organisms and BSIs in children with CVCs who underwent HSCT. Methods: We performed a retrospective analysis of 78 children who received allogeneic HSCT over 3 years (2012-2014). Surveillance stool cultures were analyzed pre- and post-HSCT to assess correlations between organisms isolated from stool and CVC cultures. Results: Twenty-four of 78 children experienced 31 BSIs. Fifteen (48%) of these isolates were identified in stool within 30 days of the positive blood culture, and 11 (36%) isolates met criteria for MBI-LCBI. Conclusions: Mucosal barrier injury leads to translocation of pathogenic organisms into the bloodstream and accounts for a significant number of BSIs in children undergoing HSCT. Nursing assessment of mucosal changes during HSCT and interventions to preserve intact mucosa are essential to prevent MBI-LCBI.

Bloodstream Infections With Candida auris Among Children in Colombia: Clinical Characteristics and Outcomes of 34 Cases

2020 ◽  
Author(s):  
Indira Berrio ◽  
Diego H Caceres ◽  
Wilfrido Coronell R ◽  
Soraya Salcedo ◽  
Laura Mora ◽  
...  
Keyword(s):  
Organ Transplant ◽  
Bloodstream Infections ◽  
Venous Catheter ◽  
Multidrug Resistant ◽  
Solid Organ ◽  
Central Venous ◽  
Candida Auris ◽  
Healthcare Settings ◽  
Invasive Infections ◽  
Healthcare Associated

Abstract Background Candida auris is an emerging multidrug-resistant yeast that can cause invasive infections and healthcare-associated outbreaks. Here, we describe 34 cases of pediatric C. auris bloodstream infections (BSIs) identified during July 2014–October 2017 in 2 hospitals in Colombia. Methods We conducted a retrospective review of microbiology records for possible C. auris cases in 2 hospitals in Barranquilla and Cartagena. BSIs that occurred in patients aged <18 years confirmed as C. auris were included in this analysis. Results We identified 34 children with C. auris BSIs. Twenty-two (65%) patients were male, 21% were aged <28 days, 47% were aged 29–365 days, and 32% were aged >1 year. Underlying conditions included preterm birth (26%), being malnourished (59%), cancer (12%), solid-organ transplant (3%), and renal disease (3%). Eighty-two percent had a central venous catheter (CVC), 82% were on respiratory support, 56% received total parenteral nutrition (TPN), 15% had a surgical procedure, and 9% received hemodialysis. Preinfection inpatient stay was 22 days (interquartile range, 19–33 days), and in-hospital mortality was 41%. Conclusions Candida auris affects children with a variety of medical conditions including prematurity and malignancy, as well as children with CVCs and those who receive TPN. Mortality was high, with nearly half of patients dying before discharge. However, unlike most other Candida species, C. auris can be transmitted in healthcare settings, as suggested by the close clustering of cases in time at each of the hospitals. Candida auris is an emerging multidrug-resistant yeast that can cause invasive infections and healthcare-associated outbreaks. This report describes 34 cases of pediatric C. auris bloodstream infections, identified in two hospitals in Colombia, South America.

Health care institutional charges associated with ambulatory bloodstream infections in pediatric oncology and stem cell transplant patients

2016 ◽  
Vol 64 (2) ◽  
pp. 324-329 ◽  
Author(s):  
Chris I. Wong Quiles ◽  
Stephanie Gottsch ◽  
Usha Thakrar ◽  
Belen Fraile ◽  
Amy L. Billett
Keyword(s):  
Health Care ◽  
Stem Cell ◽  
Pediatric Oncology ◽  
Stem Cell Transplant ◽  
Bloodstream Infections ◽  
Cell Transplant ◽  
Transplant Patients
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