scholarly journals Using LiF crystals for high-performance neutron imaging with micron-scale resolution

2015 ◽  
Vol 3 ◽  
Author(s):  
A. Faenov ◽  
M. Matsubayashi ◽  
T. Pikuz ◽  
Y. Fukuda ◽  
M. Kando ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Linear Response ◽  
High Performance ◽  
Dynamic Range ◽  
High Spatial Resolution ◽  
Neutron Imaging ◽  
Optically Stimulated Luminescence ◽  
Plasma Sources ◽  
Imaging Detector ◽  
Z Pinch

This paper describes an overview of our recent discovery – clear demonstration that LiF crystals can be efficiently used as a high-performance neutron imaging detector based on optically stimulated luminescence of color centers generated by neutron irradiation. It is shown that the neutron images we have obtained are almost free from granular noise, have a spatial resolution of ${\sim}5.4~{\rm\mu}\text{m}$ and a linear response with a dynamic range of at least $10^{3}$ . The high contrast and good sensitivity of LiF crystals allow us to distinguish two holes with less than 2% transmittance difference. We propose to use such detectors in areas where high spatial resolution with high image gradation resolution is needed, including diagnostics of different plasma sources such as laser and z-pinch produced plasmas.

Measurement accuracy and Cerenkov removal for high performance, high spatial resolution scintillation dosimetry

2005 ◽  
Vol 33 (1) ◽  
pp. 128-135 ◽  
Author(s):  
Louis Archambault ◽  
A. Sam Beddar ◽  
Luc Gingras ◽  
René Roy ◽  
Luc Beaulieu
Keyword(s):  
Spatial Resolution ◽  
High Performance ◽  
Measurement Accuracy ◽  
High Spatial Resolution

Lithium fluoride crystal as a novel high dynamic neutron imaging detector with microns scale spatial resolution

2012 ◽  
Vol 9 (12) ◽  
pp. 2231-2234 ◽  
Author(s):  
Anatoly Faenov ◽  
Masahito Matsubayashi ◽  
Tatiana Pikuz ◽  
Yuji Fukuda ◽  
Masaki Kando ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Lithium Fluoride ◽  
Neutron Imaging ◽  
Fluoride Crystal ◽  
Imaging Detector ◽  
High Dynamic

scholarly journals High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry

2019 ◽  
Author(s):  
Jeffrey Spraggins ◽  
Katerina Djambazova ◽  
Emilio Rivera ◽  
Lukasz Migas ◽  
Elizabeth Neumann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Imaging ◽  
Spatial Resolution ◽  
Ion Mobility ◽  
Measurement Errors ◽  
High Performance ◽  
High Spatial Resolution ◽  
Biological Tissues ◽  
Whole Body ◽  
Trapped Ion

Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of biological tissues at cellular resolutions. New developments and technologies are essential for uncovering the molecular drivers of native physiological function and disease. Instrumentation must maximize spatial resolution, throughput, sensitivity, and specificity, because tissue imaging experiments consist of thousands to millions of pixels. Here, we report the development and application of a matrix-assisted laser desorption/ionization (MALDI) trapped ion mobility spectrometry imaging platform. This prototype MALDI timsTOF instrument is capable of 10 µm spatial resolutions and 20 pixels/s throughput molecular imaging. The MALDI source utilizes a Bruker SmartBeam 3-D laser system that can generate a square burn pattern of <10 x 10 µm at the sample surface. General image performance was assessed using murine kidney and brain tissues and demonstrate that high spatial resolution imaging data can be generated rapidly with mass measurement errors < 5 ppm and ~40,000 resolving power. Initial TIMS-based imaging experiments were performed on whole body mouse pup tissue demonstrating the separation of closely isobaric [PC(32:0)+Na]<sup>+</sup>and [PC(34:3)+H]<sup>+</sup>(3 mDa mass difference) in the gas-phase. We have shown that the MALDI timsTOF platform can maintain reasonable data acquisition rates (>2 pixels/s) while providing the specificity necessary to differentiate components in complex mixtures of lipid adducts. The combination of high spatial resolution and throughput imaging capabilities with high-performance TIMS separations provides a uniquely tunable platform to address many challenges associated with advanced molecular imaging applications.

High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry

2019 ◽  
Author(s):  
Jeffrey Spraggins ◽  
Katerina Djambazova ◽  
Emilio Rivera ◽  
Lukasz Migas ◽  
Elizabeth Neumann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Imaging ◽  
Spatial Resolution ◽  
Ion Mobility ◽  
Measurement Errors ◽  
High Performance ◽  
High Spatial Resolution ◽  
Biological Tissues ◽  
Whole Body ◽  
Trapped Ion

Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of biological tissues at cellular resolutions. New developments and technologies are essential for uncovering the molecular drivers of native physiological function and disease. Instrumentation must maximize spatial resolution, throughput, sensitivity, and specificity, because tissue imaging experiments consist of thousands to millions of pixels. Here, we report the development and application of a matrix-assisted laser desorption/ionization (MALDI) trapped ion mobility spectrometry imaging platform. This prototype MALDI timsTOF instrument is capable of 10 µm spatial resolutions and 20 pixels/s throughput molecular imaging. The MALDI source utilizes a Bruker SmartBeam 3-D laser system that can generate a square burn pattern of <10 x 10 µm at the sample surface. General image performance was assessed using murine kidney and brain tissues and demonstrate that high spatial resolution imaging data can be generated rapidly with mass measurement errors < 5 ppm and ~40,000 resolving power. Initial TIMS-based imaging experiments were performed on whole body mouse pup tissue demonstrating the separation of closely isobaric [PC(32:0)+Na]<sup>+</sup>and [PC(34:3)+H]<sup>+</sup>(3 mDa mass difference) in the gas-phase. We have shown that the MALDI timsTOF platform can maintain reasonable data acquisition rates (>2 pixels/s) while providing the specificity necessary to differentiate components in complex mixtures of lipid adducts. The combination of high spatial resolution and throughput imaging capabilities with high-performance TIMS separations provides a uniquely tunable platform to address many challenges associated with advanced molecular imaging applications.

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