scholarly journals Familial Clustering and Re-infection with 2019 Novel Coronavirus (2019-nCoV, SARS-CoV-2) in the Libyan Community

2021 ◽  
pp. 1-10
Author(s):  
Mohamed A. Daw ◽  
Amina M. Daw ◽  
Muheeb M. Miftah ◽  
Abdallah El-Bouzedi ◽  
Mohamed O. Ahmed ◽  
...  
Keyword(s):  
Familial Clustering ◽  
Novel Coronavirus

scholarly journals Presymptomatic Transmission and Diverse Progression of Familial Clustering Covid-19 Cases in Zhoushan, China

2020 ◽  
Author(s):  
Miao Liu ◽  
Leijie Liu ◽  
Ping Li ◽  
Yibo Ding ◽  
Ting Wu ◽  
...  
Keyword(s):  
Index Case ◽  
Asymptomatic Carrier ◽  
Serum Antibody ◽  
Family Members ◽  
Familial Cluster ◽  
Reverse Transcription Pcr ◽  
7Th Edition ◽  
Source Of Infection ◽  
Familial Clustering ◽  
Novel Coronavirus

Abstract Background Novel coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused emerging infectious disease, firstly identified in Wuhan (Hubei, China), is pandemic. However, data concerning presymptomatic SARS-CoV-2 transmission and disease diversity among family members are limited. Herein, We investigated the epidemiological and clinical characteristics of presymptomatic transmission-caused familial clustering cases of SARS-CoV-2 infection in Zhoushan island, China. Methods All family members were tested for SARS-CoV-2 genomic RNA by quantitative reverse transcription PCR in 3 different samples and serum antibody immunoglobin M (IgM) and IgG against SARS-CoV-2. Exposure identification, laboratory test, and imaging were performed according to the national guideline of COVID-19 (7th edition, China). Results Of the 6 cases, index case who ever met his relative with COVID-19 from Xianning, Hubei on January 26–31, 2020, transmitted SARS-CoV-2 to his family members in Zhoushan via visiting family during January 31 and February 3, 2020. The index was identified as common-type COVID-19 on February 6, 2020. All 5 family members were infected with SARS-CoV-2. Of those, a 7-year-old girl was an asymptomatic carrier whereas her grandparents, especially her grandfather, were very sick. Case 6 (grandfather) remained positive for SARS-CoV-2 RNA in his sputum specimen in subsequent 2 months. Case 2 (mother) tested negative for SARS-CoV-2 RNA in all samples but positive for IgM and IgG to SARS-CoV-2 since February 9, 2020. Conclusions Presymptomatic transmission of SARS-CoV-2 causes familial cluster of COVID-19. Exposed to the same source of infection, family members present their differences in disease severity and viral clearance.

scholarly journals Presymptomatic transmission and diverse progression of familial clustering COVID-19 cases in Zhoushan, China

2020 ◽  
Author(s):  
Miao Liu ◽  
Leijie Liu ◽  
Ping Li ◽  
Yibo Ding ◽  
Ting Wu ◽  
...  
Keyword(s):  
Index Case ◽  
Asymptomatic Carrier ◽  
Serum Antibody ◽  
Family Members ◽  
Familial Cluster ◽  
Reverse Transcription Pcr ◽  
7Th Edition ◽  
Source Of Infection ◽  
Familial Clustering ◽  
Novel Coronavirus

Abstract Background Novel coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused emerging infectious disease, firstly identified in Wuhan (Hubei, China), is pandemic. However, data concerning presymptomatic SARS-CoV-2 transmission and disease diversity among family members are limited. Objectives To investigate the epidemiological and clinical characteristics of presymptomatic transmission-caused familial clustering cases of SARS-CoV-2 infection in Zhoushan island, China. Methods All family members were tested for SARS-CoV-2 genomic RNA by quantitative reverse transcription PCR in 3 different samples and serum antibody immunoglobin M (IgM) and IgG against SARS-CoV-2. Exposure identification, laboratory test, and imaging were performed according to the national guideline of COVID-19 (7th edition, China). Results Of the 6 cases, index case who ever met his relative with COVID-19 from Xianning, Hubei on January 26–31, 2020, transmitted SARS-CoV-2 to his family members in Zhoushan via visiting family during January 31 and February 3, 2020. The index was identified as common-type COVID-19 on February 6, 2020. All 5 family members were infected with SARS-CoV-2. Of those, a 7-year-old girl was an asymptomatic carrier whereas her grandparents, especially her grandfather, were very sick. Case 6 (grandfather) remained positive for SARS-CoV-2 RNA in his sputum specimen in subsequent 2 months. Case 2 (mother) tested negative for SARS-CoV-2 RNA in all samples but positive for IgM and IgG to SARS-CoV-2 since February 9, 2020. Conclusions Presymptomatic transmission of SARS-CoV-2 causes familial cluster of COVID-19. Exposed to the same source of infection, family members present their differences in disease severity and viral clearance.

scholarly journals Epidemiologic Features of 135 Patients With Coronavirus Disease (COVID-19) in Tianjin, China

2020 ◽  
Vol 14 (5) ◽  
pp. 630-634 ◽  
Author(s):  
Chunxia Cao ◽  
Yue Li ◽  
Shuyu Liu ◽  
Haojun Fan ◽  
Liangchen Hao
Keyword(s):  
Urban Areas ◽  
Early Stage ◽  
Case Fatality ◽  
Scientific Basis ◽  
Control Measures ◽  
Familial Clustering ◽  
Prevention And Control Measures ◽  
Novel Coronavirus ◽  
And Control ◽  
Epidemiologic Features

ABSTRACTObjective:This study describes the epidemiologic features of an outbreak of the coronavirus disease (COVID-19) in Tianjin caused by a novel coronavirus and provides the scientific basis for prevention and control measures.Methods:Data from COVID-19 cases were collected from daily notifications given to the National Health Commission of the People’s Republic of China and Tianjin Health Committee. All of the data were analyzed with SPSS, version 24.0 software (IBM Corp, Armonk, NY).Results:As of February 24, 2020, there have been 135 confirmed cases, 3 deaths, and 87 recoveries in Tianjin, China. The incidence of COVID-19 was 8.65/1 000 000 with a 2.22% case fatality rate. Regarding geographic distribution, the incidence was 8.82 per 1 000 000 in urban areas and 8.00 per 1 000 000 in suburbs. During the early stage of the epidemic, most cases came from urban areas and in patients with a history of sojourning in Hubei Province. The majority of patients were 31–70 years old (75.97%). A familial clustering was the most important characteristic of COVID-19 (accounting for 74.81%).Conclusions:Current information suggests that people are generally susceptible to COVID-19, which has shown a familial clustering in Tianjin.

scholarly journals Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

2020 ◽  
Vol 286 ◽  
pp. 198043 ◽  
Author(s):  
Jinzhong Li ◽  
Xiaobing Gong ◽  
Zhigang Wang ◽  
Renzhou Chen ◽  
Taoyuan Li ◽  
...  
Keyword(s):  
Clinical Features ◽  
Familial Clustering ◽  
Novel Coronavirus

Ergebnisse der COVID-19-Umfrage der Deutschen Gesellschaft für Rehabilitationswissenschaften e.V. (DGRW)

2020 ◽  
Vol 59 (05) ◽  
pp. 315-317
Author(s):  
Thorsten Meyer ◽  
Elain Posthumus ◽  
Keyword(s):  
Public Health ◽  
Global Literature ◽  
Novel Coronavirus

Hintergrund und ZielCOVID-19 stellt eine substanzielle Bedrohung der Gesundheit und in der Folge auch der Lebensbedingungen der Menschen weltweit dar. Die Erkrankung entsteht infolge einer Infektion mit dem neuartigen Coronavirus SARS-CoV-2. Erkenntnisse über molekulare Grundlagen, Pathophysiologie, klinische Charakteristika, Epidemiologie, aber auch Ressourcenbedarf und Outcomes (z. B. Karagiannidis et al. 2020; zur Übersicht s. Website der WHO: https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/) wachsen in beispiellos kurzem Zeitraum weltweit an, auch im Feld der Rehabilitation (vgl. Negrini et al. 2020). Die Erkenntnisse münden in Leitlinien, Policy Briefs oder konkreten Handlungsempfehlungen (vgl. Publikationen des Kompetenznetz Public Health COVID-19, www.public-health-covid19.de).

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

Drug Repurposing Studies Targeting SARS-nCoV2: An Ensemble Docking Approach on Drug Target 3C-like Protease (3CLpro)

2020 ◽  
Author(s):  
Shruti Koulgi ◽  
Vinod Jani ◽  
Mallikarjunachari Uppuladinne ◽  
Uddhavesh Sonavane ◽  
Asheet Kumar Nath ◽  
...  
Keyword(s):  
Drug Repurposing ◽  
Drug Binding ◽  
Ensemble Docking ◽  
Drug Molecules ◽  
Drug Binding Site ◽  
Main Protease ◽  
Docking Approach ◽  
Novel Coronavirus ◽  
Markov State Modeling ◽  
Viral Polyprotein

<p>The COVID-19 pandemic has been responsible for several deaths worldwide. The causative agent behind this disease is the Severe Acute Respiratory Syndrome – novel Coronavirus 2 (SARS-nCoV2). SARS-nCoV2 belongs to the category of RNA viruses. The main protease, responsible for the cleavage of the viral polyprotein is considered as one of the hot targets for treating COVID-19. Earlier reports suggest the use of HIV anti-viral drugs for targeting the main protease of SARS-CoV, which caused SARS in the year 2002-03. Hence, drug repurposing approach may prove to be useful in targeting the main protease of SARS-nCoV2. The high-resolution crystal structure of 3CL<sup>pro</sup> (main protease) of SARS-nCoV2 (PDB ID: 6LU7) was used as the target. The Food and Drug Administration (FDA) approved and SWEETLEAD database of drug molecules were screened. The apo form of the main protease was simulated for a cumulative of 150 ns and 10 μs open source simulation data was used, to obtain conformations for ensemble docking. The representative structures for docking were selected using RMSD-based clustering and Markov State Modeling analysis. This ensemble docking approach for main protease helped in exploring the conformational variation in the drug binding site of the main protease leading to efficient binding of more relevant drug molecules. The drugs obtained as best hits from the ensemble docking possessed anti-bacterial and anti-viral properties. Small molecules with these properties may prove to be useful to treat symptoms exhibited in COVID-19. This <i>in-silico</i> ensemble docking approach would support identification of potential candidates for repurposing against COVID-19.</p>

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