scholarly journals 4400 Low CD4 nadir linked to widespread cortical thinning in adults with HIV

2020 ◽  
Vol 4 (s1) ◽  
pp. 11-11
Author(s):  
Shiva Hassanzadeh-Behbahani ◽  
Kyle F. Shattuck ◽  
Margarita Bronshteyn ◽  
Matthew Dawson ◽  
Monica Diaz ◽  
...  
Keyword(s):  
Strong Predictor ◽  
Neuropsychological Test ◽  
Structural Mri ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Asymptomatic Neurocognitive Impairment ◽  
Cortical Thinning ◽  
Siemens Scanner ◽  
History Of ◽  
Age Range

OBJECTIVES/GOALS: The history of immune suppression, especially CD4 nadir, has been shown to be a strong predictor of HIV-associated neurocognitive disorders (HAND). However, the potential mechanism of this association is not well understood. This study examined the relationship between CD4 nadir and brain atrophy. METHODS/STUDY POPULATION: Fifty-nine people with HIV participated in the cross-sectional study (mean age, 56.5 ± 5.8; age range, 41-69; 15 females; 46 African-Americans). High resolution structural MRI images were obtained using a 3T Siemens scanner. From a comprehensive 7-domain neuropsychological test battery, a global deficit score (GDS) and HAND diagnoses were determined for each participant. The correlation between CD4 nadir (the lowest ever lymphocyte CD4 count) and cortical thickness was investigated using a vertex-wise non-parametric approach with a conservative statistical threshold of p < 0.05 (FWE-corrected). RESULTS/ANTICIPATED RESULTS: Out of the 59 participants, 12 met standard Frascati criteria for asymptomatic neurocognitive impairment (ANI) and two met the criteria for mild neurocognitive disorder (MND). Across all participants, low CD4 nadir was associated with widespread cortical thinning, especially in the frontal and temporal regions. Higher GDS (indicating worse global neurocognitive function) was associated with bilateral frontal cortical thinning, and the association largely persisted in the subset of participants who did not meet HAND criteria. DISCUSSION/SIGNIFICANCE OF IMPACT: These results suggest that the low CD4 nadir may be associated with widespread neural injury in the brain, especially in the frontal and temporal regions. This spatial profile might contribute to the prevalence/phenotypes of HAND in the cART era, such as the frequently observed deficits in the executive domain.

COVID-19: An Experience from a Tertiary Care Hospital of Nowshera

2020 ◽  
Vol 24 (2) ◽  
pp. 149-155
Author(s):  
Hamzullah Khan ◽  
Mohammad Zahid Khan ◽  
Mian Mohammad Naveed
Keyword(s):  
Tertiary Care ◽  
Relevant Information ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Epidemic Area ◽  
History Of ◽  
Severity Of The Disease ◽  
Age Range

Objective: To determine the frequency of COVID-19 and characteristics of patients presenting to the COVID-19 clinic at Qazi Hussain Ahmed Medical Complex (QHAMC) Nowshera. Methodology: This cross-sectional study was conducted from 21st Feb 2019 to April 8, 2020, in QHAMC Nowshera. Relevant information was collected on a pre-designed Performa prepared following the objectives of the study. Results: Out of 220 patients, 165(75%) were males, and 55(25%) females. 96(43.6%) of the patients were in the age range 18-30 years followed by 52(23.6%) in age range 31-45years and 17(7.7%) with age>60 years etc. Out of total the nasopharyngeal swabs of 26(11.6%) strong suspects were sent for PCR testing. 208(94.5%) were sent home while 12(5.5%) were advised quarantine. Forty-seven (21.4%) had a travel history to an epidemic area in the last 14 days. 51(23.2%) had a positive history of contact. Eighty-five (38.6%) had a fever and sore throat followed by 27(12.3%) with (fever & cough), 24(10.9%) with (cough and shortness of breath/dyspnea) and 14(6.4%) with a simple flue, etc. Out of 26 cases, 6(2.7%) were COVID-19 Positive, 12(5.5%) were negative and results of 8(3.6%) were still awaited. The PCR repeated the test for confirmed cases showed;  4(1.8%) negative, one died and one was refractory positive.  A positive correlation (p=0.03, r=0.4) of an increase in age with the severity of the disease/outcome was recorded. Conclusion: The frequency of infectivity with COVID-19 was 2.6%. A higher number of patients with mild symptoms attend the COVID clinic. The rate of infection and mortality was higher in age> 60 years.

scholarly journals Association of polycystic ovary syndrome with insulin resistance and glucose transporter GLUT 4.

2020 ◽  
Vol 27 (10) ◽  
pp. 2182-2186
Author(s):  
Roohi Jabbar ◽  
Rukhshan Khurshid ◽  
Uzma Jabbar ◽  
Mudassir Zia ◽  
Abeera Mazhar Siddiqui ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Transporter ◽  
Fasting Glucose ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glut 4 ◽  
History Of ◽  
Age Range ◽  
Study Setting

Objectives: The study was designed to find out the association of PCOS with insulin resistance and GLUT4. Study Design: Cross Sectional study. Setting: Outdoor Department of Sir Ganga Ram Hospital Lahore. Period: March 2016 to December 2016. Material & Methods: 37 PCOS women visited Outdoor Department of Sir Ganga Ram Hospital Lahore. Their age range was 25- 36 years. 20 ages matched medical staff of the Sir Ganga Ram Hospital, Lahore with no history of any disease were selected as control. Rotterdam’s criteria were used to confirm PCOS. Levels of circulating insulin, GLUT 4 and fasting glucose were estimated. Results: Mean age of PCOS patients and of controls was 30.55 and 29.00 years respectively. Values of BMI were insignificantly raised in PCOS in comparison to controls. Levels of circulating GLUT-4, fasting glucose, insulin and resistance of insulin were increased significantly in women with PCOS in comparison to the controls. Decreased ratio of glucose to insulin was seen in PCOS women in comparison to their controls. Conclusion: A good association of PCOS was observed with insulin mediated release of glucose transporter GLUT 4 and insulin resistance.

Frequency of Asymptomatic Bacteriuria in Pregnant Women

2021 ◽  
Vol 15 (10) ◽  
pp. 3520-3523
Author(s):  
Muneeba Sadaf ◽  
Afshan Zaman ◽  
Fatima Bibi ◽  
Maria Tariq ◽  
Uzma Nayyer ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pregnant Women ◽  
Gestational Age ◽  
Asymptomatic Bacteriuria ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Urinary Tract Stones ◽  
History Of ◽  
One Year ◽  
Age Range

Objectives: To determine the frequency of asymptomatic bacteriuria in pregnantwomen. Study design: Descriptive, Cross sectional study Place and Duration: Department of Obstetrics & Gynaecology, Benazir Bhutto Hospital, Rawalpindi. 26th December 2017 to 25th June 2018 Materials & Methods: A total of 151 pregnant women of gestational age ≥28 weeks, 18 to 40 years of age were included. Patients with genital tract trauma, history of UTI in the past one year and urinary tract stones were excluded. Then clean-catch midstream urine was collected from each woman into a sterile universal container and sample was sent to the institutional laboratory for presenceor absence of asymptomatic bacteriuria. Results: Age range in this study was from 18 to 40 years with mean age of 28.78 ± 3.90 years. Majority of the patients 84 (55.63%) were between 18 to 30 years of age. Mean gestational age was 31.06 ± 1.67 weeks. Mean parity was 3.17 ± 0.99. Mean BMI was 27.44 ± 3.02 kg/m2. In our study, frequency of asymptomatic bacteriuria in pregnant women was found in 25 (16.56%) patients. Conclusion: This study concluded that frequency of asymptomatic bacteriuria in pregnant women is quite high. Keywords: Asymptomatic Bacteriuria, Pregnancy, Urinary Tract Infection.

scholarly journals Changing Pattern of Post-infectious Glomerulonephritis: A Study in South-Western Region of Bangladesh

2020 ◽  
Vol 32 (2) ◽  
pp. 130-133
Author(s):  
Muhammed Arshad Ul Azim ◽  
Md Motiur Rahaman ◽  
Kamruzzaman Md Zahir ◽  
Md Obaidul Hauque ◽  
Md Abdul Wadud ◽  
...  
Keyword(s):  
Renal Impairment ◽  
Cross Sectional Study ◽  
Recent History ◽  
Cross Sectional ◽  
Male Predominance ◽  
History Of ◽  
Medicine Today ◽  
Age Range ◽  
Post Infectious

Introduction: In developing countries like Bangladesh, post-infectious glomerulonephritis (PIGN) is the common form ofacute glomerulonephritis having its changing pattern over recent decades. The aim of the study was to analyze the clinicalprofile of PIGN in local scenario. Materials and Methods: This cross-sectional study was conducted at Shaheed Sheikh AbuNaser Specialized Hospital, Khulna during period from 2017 to 2019. A total of 67 cases of PIGN were identified on thebasis of clinical features, laboratory parameters with recent history of infection. The patients’ records were reviewed withrespect to clinical data. Patients with reduced complement level were included. Result: The age range of the patients wasbetween 2 and 55 years with male predominance. The study revealed that 32.8% of patients had a recent history of sorethroat, 31.3 % of patients had a history of skin infection and rest 35% had a history of fever. Moreover, during presentation68% of patients had hypertension and 37 % of patient had renal impairment. In this study, majority of patients (53%)presented with one plus to two plus proteinuria and the rest of the patients (37%) presented with three plus proteinuria ondipstick. After 2 weeks of follow up, the presence of hematuria found in 58 patients out of 67, proteinuria found in 14patients out of 61 and renal impairment found in 5 patients out of 25. Conclusion: PIGN has been changing with respect toage, proteinuria and renal function. To follow-up periodically and reduction in overcrowding of the patients, would be oneof the superior suggestions to reduce the spread of infectious diseases in our country. Medicine Today 2020 Vol.32(2): 130-133

scholarly journals PRETERM LABOUR

2018 ◽  
Vol 25 (09) ◽  
pp. 1342-1345
Author(s):  
Saima Ashraf ◽  
Shahida Parveen ◽  
Shahzad Alam
Keyword(s):  
Preterm Labour ◽  
Serum Magnesium ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Serum Magnesium Level ◽  
Amniotic Fluid Index ◽  
Singleton Pregnancy ◽  
Cross Sectional ◽  
History Of ◽  
Age Range

Objectives: To determine the frequency of hypomagnesaemia in women withpreterm labour. Study Design: Cross sectional study. Settings: Department of obstetrics &gynaecology Nishtar Hospital Multan. Duration of Study: From 10th November 2016 to 10th May2017. Subject and Methods: A total of 219 pregnant women with singleton pregnancy, pretermlabour and parity 1 – 4 were included in the study. Women with history of diabetes, hypertensionsmoking and polyhhydramnious amniotic fluid index (AFI)>25 cm on ultrasound were excluded.Venous blood was drawn from entire subjects to evaluate the serum magnesium level and sentimmediately to laboratory for analysis venous blood samples were obtained by venepunctureand collected in lithium heparin specimen bottles. Data was collected for hypomagnesaemia.Results: Age range in this study was from 20 to 40 years with mean age of 30.356±3.60 years,mean parity 1.936± 0.96, mean gravida 2.936 ± 0.96, mean gestational age 32.000±2.25weeks and mean BMI was 27.337 ± 1.67 kg/m2. Majority of the patients were from 20 – 30 years(51.1%). History of preterm delivery was 17.4%. Majority of patients belong to middle economicstatus (66.2%). Hypomagnesaemia was seen in 37.9% patients. Conclusion: it is concludedthat low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour.Maternal hypomagnesaemia may be used as a predictor of preterm labour.

scholarly journals Prevalence and determinants of erectile dysfunction in Santos, southeastern Brazil

2002 ◽  
Vol 120 (2) ◽  
pp. 49-54 ◽  
Author(s):  
Edson Duarte Moreira Júnior ◽  
Walter Jorge Bestane ◽  
Elaine Bestane Bartolo ◽  
João Antônio Saraiva Fittipaldi
Keyword(s):  
Erectile Dysfunction ◽  
Strong Predictor ◽  
The United States ◽  
Population Based ◽  
Cross Sectional Study ◽  
Southeastern Brazil ◽  
Cross Sectional ◽  
Heavy Smoking ◽  
Potential Risk Factors ◽  
History Of

CONTEXT: Recent population-based surveys suggest that the prevalence of erectile dysfunction is between 30% and 56% among men over the age of 40. Most of these studies, however, are from the United States or Europe. We need estimates of erectile dysfunction from samples of Brazilian populations, as societies that differ ethnically, culturally, and economically may also differ with respect to potential risk factors for erectile dysfunction. OBJECTIVE: To determine the prevalence of erectile dysfunction and its potential correlates. SETTING: Santos, State of São Paulo. DESIGN: Cross-sectional study. PARTICIPANTS: A population-based sample of men aged 40-70 years. Out of 718 men invited, 342 (47.6%) returned a completed questionnaire. MAIN MEASUREMENTS: Data on demographic variables, medical history, lifestyle habits and degree of erectile dysfunction. RESULTS: The prevalence of any degree of erectile dysfunction was 45.9% (minimal, 33.9%; moderate, 8.5%; complete, 3.5%) and increased with age. In bivariate age-adjusted analyses comparing men with no erectile dysfunction or minimal erectile dysfunction with those with moderate or complete erectile dysfunction, histories of diabetes or hypertension, depressive symptoms, heavy smoking and obesity were significantly associated with increased prevalence of erectile dysfunction, whereas moderate alcohol consumption was inversely associated with erectile dysfunction. In the multivariate model, age was a strong predictor of erectile dysfunction, while history of diabetes or hypertension and heavy smoking remained significantly associated with increased prevalence of erectile dysfunction. CONCLUSION: We found higher prevalence of erectile dysfunction (45.9%) among men older than 40 years old in Brazil. The variables associated with erectile dysfunction may alert physicians to patients who are at risk of erectile dysfunction as well as offer clues to the etiology of erectile dysfunction. Physicians should routinely ask their patients about sexual health and erectile dysfunction.

scholarly journals PATIENTS WITH SUICIDE ATTEMPT

2015 ◽  
Vol 22 (10) ◽  
pp. 1321-1326
Author(s):  
Jamil Junejo ◽  
Badaruddin Junejo ◽  
Inayatullah Awan ◽  
Asma Perveen
Keyword(s):  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Family Issues ◽  
Younger Age ◽  
History Of ◽  
Age Range ◽  
Study Setting ◽  
Status Level

Objective: To determine the demographic details (gender, age, marital status,level of education, and occupation) of suicide attempters attending the tertiary care hospitalservices at Hyderabad, Pakistan. Study Design: Cross sectional study. Setting: Liaquat universityhospital Hyderabad and Sir Cowasjee Jahangir Institute of psychiatry (CIJP) Hyderabad.Period: Twelve months from the 1st January 2011 to 31st December 2011. Methodology:The aim of the study was. Patients with a history of attempted suicide. Two hundred (200)consecutive cases were recruited and selected according to the inclusion criteria. An informedconsent was obtained from patients for being included in the study. A specially designed semistructuredProforma was used to record demographic details of the patients. Data were enteredinto and analyzed through statistical software SPSS version 20. Results: Total 200 hundredcases were included in the study. Males 78.5 % (N=157) outnumbered female patients 21.5% (N= 43). The age range of study subjects was between 15 -59 years. Mean age of the totalcases was 22.6 years. Majority of the patients presenting with suicide were single comprising61 % (N= 122) of study cases with a P value < 0.001. Total cases of married subjects were 27.5% (N= 55) with a P value < 0.001. While 5.5% subjects were separated and 6 % were divorced.Unskilled labors made the largest group comprising of 24.5 % (N=49) of all the cases. Otheroccupations included farmers (15.5 %), skilled labor (15%), jobless (11.5%), house wives (8.5%), students (7 %), and shopkeepers (6%). Out of the total 200 patients with attempted suicide32% were illiterate, 33.5 % were educated up to primary level, 19.5% were matriculate, 09 %were intermediate passed, and only 6 % were graduate. (Table-II). Conclusion: In Pakistan stillSuicide attacks are reported. Our results suggest that suicidal thoughts can be entirely predictby common reported in male and younger age due to very sensitive to family issues, lowereducation level and major depression due to unemployment or low level earning of unskilledlabor occupation in the Pakistan population.

Suicidal Ideation Among Medical Students in Dammam, Saudi Arabia

Crisis ◽  
2020 ◽  
pp. 1-6
Author(s):  
Mohammed Madadin ◽  
Ritesh G. Menezes ◽  
Maha A. Alassaf ◽  
Abdulaziz M. Almulhim ◽  
Mahdi S. Abumadini ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Medical Students ◽  
Suicidal Ideation ◽  
General Health Questionnaire ◽  
Cross Sectional Study ◽  
Eastern Province ◽  
Cross Sectional ◽  
The Past ◽  
Depression Subscale ◽  
History Of

Abstract. Background: Medical students are at high risk of suicidal ideation. Aim: We aimed to obtain information on suicidal ideation among medical students in Dammam located in the Eastern Province of Saudi Arabia. Method: This cross-sectional study was conducted at the College of Medicine affiliated with Imam Abdulrahman Bin Faisal University in the Eastern Province of Saudi Arabia. Suicidal ideation in the past 12 months was assessed based on responses to four questions in the depression subscale of the General Health Questionnaire 28 (GHQ-28). In addition, data were collected to examine the association of suicidal ideation with various factors. Results: We found that 1 in 3 medical students in the study had suicidal ideation in the past 12 months, while around 40% had lifetime suicidal ideation. Suicidal ideation was associated with feelings of parental neglect, history of physical abuse, and dissatisfaction with academic performance. Limitations: The cross-sectional nature of this study limits its ability to determine causality regarding suicidal ideation. Conclusion: These rates are considerably high when compared with rates from studies in other countries around the world. This study provides a reference in the field of suicidology for this region of Saudi Arabia.

DYSLIPIDEMIA IN THYROID DISORDERS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Kashish Narula ◽  
Narendra Kumar Dara ◽  
Shyam Lal Meena
Keyword(s):  
Lipid Metabolism ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Control Group ◽  
Thyroid Disorders ◽  
Cross Sectional ◽  
Carbohydrate And Lipid Metabolism ◽  
History Of ◽  
Thyroid Profile ◽  
Basal Energy Expenditure

Background: Thyroid hormones influence nearly all major metabolic pathways. Their most obvious and well-known action is the increase in basal energy expenditure obtained by acting on protein, carbohydrate and lipid metabolism. The lipid metabolism is more influenced by the thyroid hormone. Methods: A cross-sectional study was conducted on 100 patients with suspicion of thyroid disorders were taken as cases. One hundred patients with normal thyroid profile and no history of other chronic diseases were taken as control group. Results: The serum TC, TG and LDL levels in hypothyroid individuals (both overt and subclinical) were significantly higher than euthyroid subjects but the levels were comparable between hyperthyroid and euthyroid group. Conclusion: Dyslipidemias are associated with thyroid disorders, so biochemical screening for thyroid dysfunction in all dyslipidemic patients. Therefore, patients presenting with dyslipidemia are recommended for investigation to explore thyroid dysfunction. Keywords: Thyroid profile, Total cholesterol, Triglycerides and LDL

Metabolic Syndrome in HIV-patients in Antiretroviral Therapy

2020 ◽  
Vol 18 (6) ◽  
pp. 388-395
Author(s):  
Daniel Vargas-Pacherrez ◽  
Helma P. Cotrim ◽  
Leonardo Pires ◽  
Vitor Cunha ◽  
Vitor Coelho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
International Diabetes Federation ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Anthropometric Data ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension ◽  
Living With Hiv

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.

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