scholarly journals D.03 Down syndrome: clinical and EEG correlates during development

2016 ◽  
Vol 43 (S2) ◽  
pp. S13-S13
Author(s):  
S Nauth ◽  
AK Bamaga ◽  
MA Cortez
Keyword(s):  
Down Syndrome ◽  
Cognitive Abilities ◽  
Cognitive Outcomes ◽  
First Year ◽  
Pharmacological Treatments ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Analysis ◽  
First Year Of Life ◽  
Electroencephalogram Eeg

Background: Down syndrome (DS) is the primary genetic cause of mental retardation and seizures are present in an estimated 5-13% of cases. One-third of seizures in DS are infantile spasms (IS). Hypsarrythmia (HS) is the cardinal electroencephalogram (EEG) feature of IS and has been found to affect cognition; however, its effect on DS patients is inconclusively reported. This study assesses the correlation of HS with cognitive outcomes in DS using the largest sample size to date. Methods: Retrospective study of medical records of children with DS [0-18yrs] at SickKids Hospital in Toronto, from 1990-2013. Seizure history, EEG findings, comorbities, and pharmacological treatments were identified. Developmental outcomes were also assessed from physician comments on motor, verbal and cognitive abilities. The cognitive outcomes of DS patients with and without HS were compared. Results: 70 [male=40] patients with DS and seizures were included. Among 31 (44.2%) patients with DS and IS, 27 had HS. Chi-square analysis showed a significant difference [P=0.007] in prevalence of severe developmental delay in patients with IS and HS versus all other seizure types. Conclusions: The developmental outcome of patients with Down syndrome appears to worsen when IS and HS had occurred in the first year of life.

Comparison of ELISA and RT-PCR assays for the detection of Tomato spotted wilt virus in peanut

2009 ◽  
Vol 36 (2) ◽  
pp. 133-137 ◽  
Author(s):  
P. M. Dang ◽  
D. L. Rowland ◽  
W. H. Faircloth
Keyword(s):  
Tomato Spotted Wilt Virus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Infection Rates ◽  
Rt Pcr ◽  
Chi Square ◽  
Tomato Spotted Wilt ◽  
Significant Difference ◽  
Pcr Assays ◽  
Chi Square Analysis ◽  
Wilt Virus

Abstract Diagnosis of Tomato spotted wilt virus (TSWV) in peanut can be accomplished by enzyme-linked immunosorbent assay (ELISA) or reverse transcription polymerase chain reaction (RT-PCR) but there has been no report of a direct comparison of the success of the two assays in evaluating infection rates of field-grown peanut. We collected peanut root samples from field-grown plants, 76 in 2006 and 48 in 2007, and tested these samples by both ELISA and RT-PCR assays for the presence of TSWV. Out of 124 samples, 50 (40.3%) and 57 (46.0%) were positive for TSWV by ELISA and RT-PCR respectively. In 13.7% of these samples, ELISA and RT-PCR differed in their results. However, Chi square analysis showed no significant difference between the results for these two assays. This result supports the conclusion that ELISA and RT-PCR are comparable for detecting TSWV infection rates in field-grown peanuts.

Listening and Language at 4 Years of Age

1992 ◽  
Vol 35 (3) ◽  
pp. 588-595 ◽  
Author(s):  
Judith S. Gravel ◽  
Ina F. Wallace
Keyword(s):  
Otitis Media ◽  
Cognitive Abilities ◽  
Speech Intelligibility ◽  
Test Procedure ◽  
First Year ◽  
Language Abilities ◽  
Standardized Measures ◽  
Cognitive Measure ◽  
Listening Task ◽  
First Year Of Life

The effect of early otitis media on preschoolers’ listening and language abilities was examined in a cohort of prospectively followed children. At 4 years of age, children considered otitis negative and otitis positive during the first year of life were examined using a speech-incompetition task and several standardized measures of language and cognitive function. An adaptive test procedure was used, with sentence materials from the Pediatric Speech Intelligibility Test (PSI) (Jerger & Jerger, 1984). Results indicated that children with positive histories of otitis media during the first year required a more advantageous signal-to-competition ratio to perform at 50% sentence intelligibility than did their otitis-negative peers. There was no interaction between birth status (high-risk or full-term) and adaptive PSI listening task outcome. No differences between the groups were found In either receptive or expressive language abilities or in cognitive abilities. Further, there was no relationship between any language or cognitive measure and the adaptive PSI result

scholarly journals Parasitology and urban livestock farming in Nigeria : prevalence of ova in faecal and soil samples and animal ectoparasites in Makurdi

2007 ◽  
Vol 78 (1) ◽  
Author(s):  
E.A. Omudu ◽  
E.U. Amuta
Keyword(s):  
Test Tube ◽  
Soil Samples ◽  
Helminth Parasites ◽  
Livestock Farming ◽  
Chi Square ◽  
Zoonotic Infections ◽  
Faecal Samples ◽  
Significant Difference ◽  
Flotation Technique ◽  
Chi Square Analysis

Domestic environmental pollution resulting from urban livestock farming was investigated in Makurdi using parasitological techniques. The test tube flotation technique was used for the parasitological analysis of animal faecal matter and soil samples collected from residential premises. Ectoparasitic fauna of dogs, goats, sheep and cattle cohabiting with humans within the same residential compound were also collected and identified. The hand-picking and body brushing methods were employed to search for ticks, fleas, lice and mites. Of the 150 soil samples examined, 55 (36.7 %) were positive for 1 or more eggs of helminth parasites. There was no significant difference in the distribution of eggs in the soil samples from the 3 areas sampled (c2=0.046, df=2, P>0.05). Ascaris species were the dominant parasite eggs found. Of the 180 faecal samples examined, 107 (59.4 %) were positive for 1 or more eggs of helminth parasites. Chi-square analysis showed no significant difference in the level of infection of different animal faeces sampled (c2=5.74, df=4, P>0.05). Ascaris species were again the dominating helminth parasite eggs found. There was also no significant difference in the prevalence of helminth eggs in the animal faecal samples from the 3 areas sampled (c2=5.99, df=4, P>0.05). A total of 1908 ectoparasites was recovered (ticks: 32.80 %; lice: 22.43 %; fleas: 22.06% and mite: 22.69 %). There was no significant difference in infestation animals between sexes (c2=0.10, df=4, P>0.05). The predominant genus encountered for ticks were Amblyomma, while Linognathus (43.90%), Ctenocephalides (97.38%) and Sarcoptes (58.89 %) were most predominant for lice, fleas and mites respectively. The public health implications of the findings, especially as these relate to the increasing incidence and prevalence of zoonotic infections, are discussed.

scholarly journals Effect of Different Doses of 17 Α -Methyltestosterone on Masculinization, Pre-Post Treatment Growth Parameters and Condition Factor of Sarotherodon Melanotheron in Pond System

2021 ◽  
pp. 56-62
Author(s):  
Theophilus Apenuvor ◽  
John Blay ◽  
Joseph Aggreyfynn ◽  
Simon Drafor
Keyword(s):  
Condition Factor ◽  
Growth Parameters ◽  
Post Treatment ◽  
Optimum Level ◽  
Male Population ◽  
Chi Square ◽  
Significant Difference ◽  
The Individual ◽  
Chi Square Analysis ◽  
Sarotherodon Melanotheron

Over-population and stunted growth had been major challenges in the culture of tilapia. The use of synthetic androgen 17- α Methyl Testosterone (MT) was a breakthrough. However, its optimum level towards effective masculinization and growth is a concern. The aim of this research was to ascertain the optimum level of MT towards effective all-male population production and growth of Black-Chinned tilapia. In the present study, the effect of different dose rates of synthetic androgen 17-α Methyl Testosterone (MT) i.e., 0, 30, 60, and 120 mg of the hormone per kg of feed on sex, growth, and condition of Black-Chinned tilapia was evaluated. MT was administered orally by using powdered dry starter feed (Crude Protein 40 %) and Ethanol. The fry was fed for 30 days in the experimental tanks. At the end of the experiment, the sex ratios were determined by examining the operculum coloration as a means of sex identification. Growth performance was monitored by measuring and recording the morphometric characteristics. Bodyweight and total length of the fish on the start of feeding, end of feeding (one month sex reversal period), and two months after feeding were measured. The results of the present study showed that all MT receiving treatment showed a significantly higher male proportion than the control (0 mg MT/kg feed individuals). In all MT treatments groups, the control expects the 30 mg MT/kg in feed individuals’ deviate significantly from the normal 1:1 sex ratio (Chi-square analysis). The dose rate of 120 mg MT /kg feed resulted in the maximum male population (92.7%). Hence, for an effective high percentage of all-male population production in Black-Chinned tilapia, 120 mg MT /kg in feed is recommended. In terms of growth and condition factor, all the individual treatments, as well as the control, showed no significant difference. All the treated individuals showed similar condition factors during the pre and post-treatment, however, the individuals treated with 30 mg MT /kg feed exhibited better condition during the pre-treatment than the post-treatment period. Temperature, pH and dissolved oxygen recorded in this study were within the desirable limit for tilapia.

HEMATOPOIESIS IN PREMATURE INFANTS WITH SPECIAL CONSIDERATION OF THE EFFECT OF IRON AND OF ANIMAL-PROTEIN FACTOR

PEDIATRICS ◽  
1955 ◽  
Vol 16 (6) ◽  
pp. 753-762
Author(s):  
James A. Wolff ◽  
Alice M. Goodfellow
Keyword(s):  
Premature Infants ◽  
Animal Protein ◽  
Iron Therapy ◽  
First Year ◽  
Protein Factor ◽  
Anemia Of Prematurity ◽  
Significant Difference ◽  
One Year ◽  
First Year Of Life ◽  
Weight Groups

Normal values in the first 3 months of life have been determined for hemoglobin, erythrocytes, reticulocytes, platelets, leukocytes and differential counts for premature infants with birth weights less than 1200 gm., and for those between 1200 and 1500 gm. at birth. No significant difference was found in the degree of depression of levels of hemoglobin and erythrocytes when values in the 2 weight groups were compared. Two reticulocyte peaks occur during the first 3 months of life. The first peak is present immediately after birth. The second peak, at about the eighth week, coincides with the occurrence of the greatest degree of anemia. Neither iron therapy nor treatment with animal-protein factor containing vitamin B12 and Aureomycin®, started before the end of the third week of life, had a statistically significant effect on the early phase of the anemia of prematurity. Untreated premature infants and those given animal-protein factor were anemic at the end of the first year of life. Subjects given iron therapy had normal hemoglobin values at one year of age. Blood transfusion is rarely necessary in the treatment of the anemia of prematurity.

scholarly journals Fetal, neonatal, and post-neonatal mortality in the 2015 Pelotas (Brazil) birth cohort and associated factors

2019 ◽  
Vol 35 (7) ◽  
Author(s):  
Andrea Ramirez Varela ◽  
Bruna Celestino Schneider ◽  
Susana Bubach ◽  
Mariangela Freitas Silveira ◽  
Andréa Dâmaso Bertoldi ◽  
...  
Keyword(s):  
Neonatal Mortality ◽  
Birth Cohort ◽  
Gestational Age ◽  
Associated Factors ◽  
Reference Group ◽  
Multinomial Logistic Regression ◽  
First Year ◽  
Chi Square ◽  
Neonatal Deaths ◽  
First Year Of Life

This study aimed to describe fetal, neonatal, and post-neonatal mortality and associated factors in participants of the 2015 Pelotas (Brazil) birth cohort. The child mortality sub-study followed up all deaths in the first year of life. Data were collected on intrauterine fetal deaths (weight ≥ 500g and/or gestational age ≥ 20 weeks), neonatal deaths (< 28 days of life), and post-neonatal deaths (from 28 days to the end of the first year of life). Descriptive analyses using the Pearson chi-square test and a multinomial logistic regression to estimate the risk of fetal, neonatal, and post-neonatal deaths compared to live infants in the cohort (reference group) were performed. Data from 4,329 eligible births were collected, of which 54 died during the fetal period. Of the 4,275 eligible live births, 59 died in the first year of life. An association between fetal, neonatal, and post-neonatal deaths (OR = 15.60, 7.63, and 5.51 respectively) was found, as well as less than six prenatal consultations. Compared to live infants, fetal deaths were more likely to occur in non-white mothers, and neonatal deaths were 14.09 times more likely to occur in a preterm gestational age (< 37 weeks). Compared to live infants, infants that were born in a C-section delivery had 3.71 increased odds of post-neonatal death. Additionally, neonatal deaths were 102.37 times more likely to have a low Apgar score on the fifth minute after birth. These findings show the need for early interventions during pregnancy, ensuring access to adequate prenatal care.

scholarly journals Straight Line Scoring by Clinical Competency Committees Using Emergency Medicine Milestones

2017 ◽  
Vol 9 (6) ◽  
pp. 716-720 ◽  
Author(s):  
Michael S. Beeson ◽  
Stanley J. Hamstra ◽  
Melissa A. Barton ◽  
Kenji Yamazaki ◽  
Francis L. Counselman ◽  
...  
Keyword(s):  
Emergency Medicine ◽  
Descriptive Analysis ◽  
Chi Square ◽  
Residency Programs ◽  
Reporting Requirement ◽  
Straight Line ◽  
Significant Difference ◽  
Chi Square Analysis ◽  
Academic Year ◽  
Nominal Variables

ABSTRACT Background  In 2013, milestone ratings became a reporting requirement for emergency medicine (EM) residency programs. Programs rate each resident in the fall and spring on 23 milestone subcompetencies. Objective  This study examined the incidence of straight line scoring (SLS) for EM Milestone ratings, defined as a resident being assessed the same score across the milestone subcompetencies. Methods  This descriptive analysis measured the frequencies of SLS for all Accreditation Council for Graduate Medical Education (ACGME)–accredited EM programs during the 2015–2016 academic year. Outcomes were the frequency of SLS in the fall and spring milestone assessments, changes in the number of SLS reports, and reporting trends. Chi-square analysis compared nominal variables. Results  There were 6257 residents in the fall and 6588 in the spring. Milestone scores were reported for 6173 EM residents in the fall (99% of 6257) and spring (94% of 6588). In the fall, 93% (5753 residents) did not receive SLS ratings and 420 (7%) did, with no significant difference compared with the spring (5776 [94%] versus 397 [6%]). Subgroup analysis showed higher SLS results for residents' first ratings (183 of 2136 versus 237 of 4220, P &lt; .0001) and for their final ratings (200 of 2019 versus 197 of 4354, P &lt; .0001). Twenty percent of programs submitted 10% or more SLS ratings, and a small percentage submitted more than 50% of ratings as SLS. Conclusions  Most programs did not submit SLS ratings. Because of the statistical improbability of SLS, any SLS ratings reduce the validity assertions of the milestone assessments.

scholarly journals Borderline Dysplasia with Acetabular Retroversion: Key Findings from a Large Hip Arthroscopy Study Group

2020 ◽  
Vol 8 (7_suppl6) ◽  
pp. 2325967120S0043
Author(s):  
Benjamin Kivlan ◽  
Shane Nho ◽  
Andrew Wolff ◽  
John Salvo ◽  
John Christoforetti ◽  
...  
Keyword(s):  
Hip Arthroscopy ◽  
Arthroscopic Surgery ◽  
Acetabular Retroversion ◽  
Control Groups ◽  
Chi Square ◽  
Crossover Sign ◽  
Center Edge ◽  
Significant Difference ◽  
Chi Square Analysis ◽  
And Control

Objectives: The radiographic crossover sign (COS) is an indicator of acetabular retroversion, classically representing anterosuperior overcoverage often treated with acetabuloplasty which could exacerbate acetabular hypovolemia in dysplasia. No prior study has investigated the prevalence of acetabular retroversion in patients with dysplasia undergoing hip arthroscopy, acetabuloplasty rates, and outcomes in this setting. Study objectives are to report the prevalence of acetabular retroversion in dysplasia, the influence of the COS on arthroscopic acetabuloplasty rates, and relative outcomes compared with control groups. Methods: A retrospective cohort study was performed from a prospectively collected multi-center database. Patients undergoing isolated hip arthroscopic surgery were assigned to dysplasia (lateral center-edge angle (LCEA) ≤ 25°) or one of two control groups: normal(LCEA 26-38°), or pincer femoroacetabular impingement (FAI)(LCEA ≥ 39°). The prevalence of COS and acetabuloplasty rates between and within study and control groups were compared (Chi square analysis). Minimum 2 year outcomes utilizing iHOT-12 were compared (analysis of variance). Results: Of 401 study patients, 64 (16%) comprised the dysplasia group, 273 (68%) normal group, and 64 (16%) pincer group. Mean LCEAs were 22.3°, 31.5°, and 42.4°, respectively (p<0.001). COS prevalence was similar between groups at 31%, 26%, and 33%, respectively (p=0.873). Acetabuloplasty rates were dependent on the amount of acetabular coverage with lowered rate in the dysplasia group(40%) and increasing rates in the normal(52%) and the pincer(90%) groups (p=0.013). Post-operative iHOT-12 scores improved in all groups (68, 74, and 77, respectively, p=0.222). Patients with a COS plus rendered acetabuloplasty reported similar scores that improved to 77, 74, and 79, respectively,(p=0.949). Patients with dysplasia with COS averaged 73.1(SD 23.3) iHOT-12 score compared to 67.1(SD: 28.7) for the patients with dysplasia without COS (p=0.466). Within the dysplasia with COS subgroup, there was no significant difference in iHOT-12 scores between the group with acetabuloplasty (77.0;SD:17.1) and without acetabuloplasty (70.4;SD:27.4,p=0.580). Conclusion: Acetabular retroversion occurs with similar prevalence in borderline dysplasia compared with non-dysplastic hips undergoing hip arthroscopy but with lower acetabuloplasty rates not influenced by the COS. Arthroscopic outcomes of dysplasia with retroversion are similarly successful and comparable with those of dysplasia and non-dysplastic hips. Although infrequently performed, acetabuloplasty did not compromise outcomes in dysplasia with retroversion.

scholarly journals Postpartum depression and child development in first year of life

2013 ◽  
Vol 30 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Maria de Lima Salum e Morais ◽  
Tania Kiehl Lucci ◽  
Emma Otta
Keyword(s):  
Child Development ◽  
Postpartum Depression ◽  
Infant Development ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Fine Motor ◽  
First Year ◽  
Chi Square ◽  
Internal Factors ◽  
First Year Of Life

The aim of the study was to investigate the characteristics of infant development at four, eight and twelve months of age, as result of postpartum depression. The prevalence of Postpartum Depression - measured by the Edinburgh Postnatal Depression Scale - at four months after delivery was 30.3%; at eight months, 26.4%; and at 12 months, 25.0%. Chi-square tests were used to compare children of mothers with and without Postpartum Depression in relation to developmental milestones. It was found developmental delay in infants of mothers with Postpartum Depression in: two interactional indicators at four months, two motor indicators at eight months and one gross motor indicator at twelve months. However, children of mothers with Postpartum Depression showed better results in one fine motor and in two language items at 12 months. The results point to the necessity of considering external and internal factors of mother and infant in the study of the effects of maternal depression on child development.

National trends in local excision and esophagectomy for cT1N0 esophageal cancer.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 62-62 ◽  
Author(s):  
Emily C. Sturm ◽  
Whitney Zahnd ◽  
John D. Mellinger ◽  
Sabha Ganai
Keyword(s):  
Esophageal Cancer ◽  
Regression Analysis ◽  
Local Excision ◽  
Clinical Characteristics ◽  
Cox Regression ◽  
Chi Square ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
Chi Square Analysis ◽  
Over Time

62 Background: Esophageal cancer management has evolved due to improvements in staging and treatment strategies. Endoscopic local excision presents an attractive option for definitive management of T1 cancers, avoiding the morbidity of esophagectomy. We hypothesized that for cT1N0 cancers, patients who underwent local excision would have lower survival compared to esophagectomy due to potential discordant staging. Methods: The National Cancer Database was queried for esophageal squamous cell carcinoma (SCC) and adenocarcinoma (AC) with AJCC T1N0 clinical stage who underwent local excision (n = 1625) or esophagectomy (n = 3255) between 1998 and 2012. Chi-square analysis was used to compare demographic and clinical characteristics by procedure. Chi-square trend analysis was performed to assess trends in procedure type over time. Cox Regression analysis was performed to assess survival by procedure controlling for demographic and clinical characteristics. Results: Between 1998 and 2012, the proportion of patients who underwent local excision increased from 12% to 50% for all patients (p < 0.001); from 17% to 40% for SCC patients (p < 0.001); and from 9% to 51% for AC patients (p < 0.001). Surgical procedure varied significantly by demographic, socioeconomic status, facility, and tumor-related factors. 65% of cT1N0 cancers had concordant clinical and pathological staging after esophagectomy, with 11% having positive nodal disease; 44% were concordant after local excision. While no significant difference was seen in unadjusted survival, adjusted Cox Regression analysis indicated worse survival after esophagectomy compared to local excision for all cases (HR 1.67; 95% CI, 1.40-2.00) and for ACs with concordant staging (HR 1.54; 95% CI, 1.11-2.14). Conclusions: Local excision for cT1N0 esophageal cancer has increased over time. Staging concordance for esophagectomy is seen in two-thirds of cases. Contrary to our hypothesis, patients undergoing local excision for T1N0 cancers have better overall survival than those undergoing esophagectomy, which may reflect early differences in mortality and/or selection bias. As this study was unable to distinguish T1a from T1b, further analysis is warranted.

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