scholarly journals Five-Year Incidence of Amyotrophic Lateral Sclerosis in British Columbia (2010-2015)

2016 ◽  
Vol 43 (6) ◽  
pp. 791-795
Author(s):  
Riley Golby ◽  
Brigitte Poirier ◽  
Marife Fabros ◽  
Jacquelyn J. Cragg ◽  
Masoud Yousefi ◽  
...  
Keyword(s):  
British Columbia ◽  
Amyotrophic Lateral Sclerosis ◽  
Incidence Rates ◽  
International Studies ◽  
For Profit ◽  
Capture Recapture ◽  
Canadian Provinces ◽  
Demographic Patterns ◽  
Incident Cases ◽  
Lateral Sclerosis

AbstractBackground: Amyotrophic lateral sclerosis (ALS) is a fatal degenerative neurological disease with significant effects on quality of life. International studies continue to provide consistent incidence values, though complete case ascertainment remains a challenge. The Canadian population has been understudied, and there are currently no quantitative data on the incidence of ALS in British Columbia (BC). The objectives of this study were to determine the five-year incidence rates of ALS in BC and to characterize the demographic patterns of the disease. Methods: The capture–recapture method was employed to estimate ALS incidence over a five-year period (2010-2015). Two sources were used to identify ALS cases: one database from an ALS medical centre and another from a not-for-profit ALS organization. Results: During this time period, there were 690 incident cases within the two sources. The capture–recapture method estimated 57 unobserved cases, corresponding to a crude five-year incidence rate of 3.29 cases per 100,000 (CI95%=3.05-3.53). The mean age of diagnosis was 64.6 (CI95%=59.7-69.4), with 63.5 (CI95%=56.9-70.1) for men and 65.7 (CI95%=58.6-72.7) for women. There was a slight male preponderance in incidence, with a 1.05:1 ratio to females. Peak numbers in incidence occurred between the ages of 70 and 79. Conclusions: The incidence of ALS in BC was found to be consistent with international findings though nominally higher than that in other Canadian provinces to date.

scholarly journals Estimated Prevalence and Incidence of Amyotrophic Lateral Sclerosis and SOD1 and C9orf72 Genetic Variants

2021 ◽  
pp. 1-12
Author(s):  
Carolyn A. Brown ◽  
Cathy Lally ◽  
Varant Kupelian ◽  
W. Dana Flanders
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Latin America ◽  
North America ◽  
Meta Analysis ◽  
Incidence Rates ◽  
Chromosome 9 ◽  
Genetic Origin ◽  
Pooled Prevalence ◽  
Incident Cases ◽  
Lateral Sclerosis

<b><i>Introduction:</i></b> Amyotrophic lateral sclerosis (ALS) is a rare neurological disorder characterized by progressive deterioration of motor neurons. Assessment of the size/geographic distribution of the ALS population, including ALS with genetic origin, is needed to understand the burden of the disease and the need for clinical intervention and therapy. <b><i>Objectives:</i></b> The main objective of this study was to estimate the number of prevalent and incident ALS cases overall and superoxide dismutase 1 (SOD1) and chromosome 9 open reading frame 72 (C9orf72) ALS in 22 countries across Europe (Belgium, France, Germany, Ireland, Italy, Netherlands, Norway, Russia, Spain, Sweden, and UK), North America (USA and Canada), Latin America (Argentina, Brazil, Colombia, Mexico, and Uruguay), and Asia (China, Japan, South Korea, and Taiwan). <b><i>Methods:</i></b> A comprehensive literature search was conducted to identify population-based studies reporting ALS prevalence and/or incidence rates. Pooled prevalence and incidence rates were obtained using a meta-analysis approach at the country and regional geographic level. A country-level pooled estimate was used when ≥2 studies were available per country and geographic regional pooled estimates were used otherwise. The proportion of cases with a SOD1 or C9orf72 mutation among sporadic (sALS) and familial (fALS) cases were obtained from a previous systematic review and meta-analysis. <b><i>Results:</i></b> Pooled prevalence rates (per 100,000 persons) and incidence rates (per 100,000 person-years) were 6.22 and 2.31 for Europe, 5.20 and 2.35 for North America, 3.41 and 1.25 for Latin America, 3.01 and 0.93 for Asian countries excluding Japan, and 7.96 and 1.76 for Japan, respectively. Significant heterogeneity in reported incidence and prevalence was observed within and between countries/geographic regions. The estimated number of 2020 ALS cases across the 22 countries is 121,028 prevalent and 41,128 incident cases. The total estimated number of prevalent SOD1 cases is 2,876 cases, of which, 1,342 (47%) were fALS and 1,534 (53%) were sALS, and the number of incident SOD1 cases is 946 (434 [46%] fALS and 512 [54%] sALS). The total estimated number of prevalent C9orf72 cases is 4,545 (1,198 [26%] fALS, 3,347 [74%] sALS), and the number of incident C9orf72 cases is 1,706 (450 [26%] fALS and 1,256 [74%] sALS). <b><i>Discussion:</i></b> The estimated number of patients with SOD1 and C9orf72 ALS suggests that although the proportions of SOD1 and C9orf72 are higher among those with fALS, the majority of SOD1 and C9orf72 ALS cases may be found among those with sALS (about 53 and 74%, respectively). These results suggest that classification of fALS based on reported family history does not capture the full picture of ALS of genetic origin.

Estimation of the amyotrophic lateral sclerosis incidence by capture-recapture method in the Limousin region of France

2000 ◽  
Vol 53 (10) ◽  
pp. 1025-1029 ◽  
Author(s):  
Pierre-Marie Preux ◽  
Michel Druet-Cabanac ◽  
Philippe Couratier ◽  
Caroline Debrock ◽  
Tri Truong ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Capture Recapture ◽  
Lateral Sclerosis

Using the Capture-Recapture Method to Estimate the Incidence of Amyotrophic Lateral Sclerosis in Beijing, China

2018 ◽  
Vol 50 (1-2) ◽  
pp. 29-34 ◽  
Author(s):  
Shenghan Zhou ◽  
Silin Qian ◽  
Xiaohan Li ◽  
Liping Zheng ◽  
Wenbing Chang ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Capture Recapture ◽  
Beijing China ◽  
Lateral Sclerosis

Estimating the Occurrence of Amyotrophic Lateral Sclerosis among Gulf War (1990–1991) Veterans Using Capture-Recapture Methods

2005 ◽  
Vol 24 (3) ◽  
pp. 141-150 ◽  
Author(s):  
Cynthia J. Coffman ◽  
Ronnie D. Horner ◽  
Steven C. Grambow ◽  
Jennifer Lindquist
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gulf War ◽  
Capture Recapture ◽  
Lateral Sclerosis

scholarly journals Amyotrophic lateral sclerosis in Brazil: 1998 national survey

2000 ◽  
Vol 58 (3A) ◽  
pp. 607-615 ◽  
Author(s):  
FLÁVIA DIETRICH-NETO ◽  
DAGOBERTO CALLEGARO ◽  
ELZA DIAS-TOSTA ◽  
HELGA ALMEIDA SILVA ◽  
MARIA ELIZABETH FERRAZ ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Age Of Onset ◽  
International Studies ◽  
Clinical Report ◽  
Private Practitioners ◽  
Bulbar Onset ◽  
History Of ◽  
Epidemiologic Characteristics ◽  
Lateral Sclerosis ◽  
Hospital Clinic

OBJECTIVES: To assess the epidemiologic characteristics of amyotrophic lateral sclerosis (ALS) in Brazil in 1998. METHOD: Structured Clinical Report Forms (CRFs) sent to 2,505 Brazilian neurologists from January to September 1998 to be filled with demographic and clinical data regarding any ALS patient seen at any time during that year. RESULTS: Five hundred and forty CRFs were returned by 168 neurologists. Data on 443 patients meeting the criteria of probable or definite ALS according to El Escorial definition were analysed: 63 probable (14.2%) and 380 definite (85.8%). Two hundred and fifty-nine (58.5%) of the patients were male, mean age of onset was 52. Spinal onset occurred in 306 patients (69%); bulbar onset in 82 (18.5%), and both in 52 (11.7%). Twenty-six (5.9%) had a family history of ALS. Two hundred and fifty-nine (58.6%) were seen by private practitioners, and 178 (40.2%) at a hospital clinic. Age-ajusted incidence shows a peak incidence at the 65-74 years old range. CONCLUSIONS: The disease's characteristics are similar to those described in international studies, except for age of onset (Brazilian patients are younger). This difference is not confirmed when figures are age-adjusted.

scholarly journals The Incidence of Amyotrophic Lateral Sclerosis in Ohio 2016–2018: The Ohio Population-Based ALS Registry

2021 ◽  
pp. 1-10
Author(s):  
Angeline S. Andrew ◽  
Erik P. Pioro ◽  
Meifang Li ◽  
Xun Shi ◽  
Jiang Gui ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Rural Areas ◽  
Clinical Information ◽  
Population Based ◽  
Incidence Rates ◽  
The State ◽  
Newly Diagnosed ◽  
Disease Etiology ◽  
Als Patients ◽  
Lateral Sclerosis

<b><i>Introduction:</i></b> Amyotrophic lateral sclerosis (ALS) is a fatal, neuromuscular disease with no cure. ALS incidence rates have not been assessed specifically in Ohio, yet the state contains both metropolitan and rural areas with a variety of environmental factors that could contribute to disease etiology. We report the incidence of ALS in Ohio residents diagnosed from October 2016 through September 2018. <b><i>Methods:</i></b> We engaged practitioners from 9 Ohio sites to identify newly diagnosed ALS patients and to complete case report forms with demographic and clinical information. ALS was diagnosed according to the Awaji criteria and classified as either definite, probable, or possible. We developed a method to estimate missing cases using a Poisson regression model to impute cases in counties with evidence of undercounting. <b><i>Results:</i></b> We identified 333 newly diagnosed ALS patients residing in Ohio during the 2-year index period and found incidence rates varied in the 88 state counties. After incorporating the estimated 27% of missing cases, the corrected crude annual incidence was 1.96/100,000 person-years, and the age- and gender-standardized incidence was 1.71/100,000 person-years (standardized to the 2010 US census). <b><i>Discussion/Conclusion:</i></b> The estimated Ohio incidence of ALS is overall similar to that reported in other states in the USA. This study reveals a geospatial variation in incidence within the state, and areas with higher rates warrant future investigation.

Utility of Capture-Recapture Methodology to Assess Completeness of Amyotrophic Lateral Sclerosis Case Ascertainment

2013 ◽  
Vol 40 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Michael Wittie ◽  
Lorene M. Nelson ◽  
Sharon Usher ◽  
Kevin Ward ◽  
Michael Benatar
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Amyotrophic Lateral Sclerosis Case ◽  
Case Ascertainment ◽  
Capture Recapture ◽  
Lateral Sclerosis

scholarly journals Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology

2011 ◽  
Vol 82 (10) ◽  
pp. 1165-1170 ◽  
Author(s):  
M. H. B. Huisman ◽  
S. W. de Jong ◽  
P. T. C. van Doormaal ◽  
S. S. Weinreich ◽  
H. J. Schelhaas ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Capture Recapture ◽  
Lateral Sclerosis
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