scholarly journals P.047 Successful management of Parkinsonism in a schizophrenic patient

2016 ◽  
Vol 43 (S2) ◽  
pp. S32-S32 ◽  
Author(s):  
GB Young ◽  
B Mulroy ◽  
R Rafiq
Keyword(s):  
Single Case ◽  
D2 Receptor ◽  
Receptor Subtypes ◽  
Antipsychotic Therapy ◽  
Dopaminergic Drugs ◽  
D3 Receptors ◽  
Receptor Profile ◽  
Schizophrenic Patients

Background: D2 receptor antagonists have been a mainstay in treating schizophrenia. Dopamine agonists used in the treatment of Parkinsonism can aggravate psychosis. Dopaminergic drugs with emphasis on other receptor subtypes with less D2 activation could reduce Parkinsonism in schizophrenic patients without seriously aggravating Parkinsonism. Rotigitine acts primarily on D3 receptors, while activity on other dopamine receptors is 8-20 times less. We report the successful treatment of a schizophenic patient with rotigitine and contend that its effectiveness relates to rotigitine’s receptor profile. Methods: Single case study with follow-up. Results: A 67 year old woman with longstanding schizophrenia developed severe, progressive Parkinsonian features over 2 years despite stable antipsychotic therapy. More than one tablet of levodopa-carbidopa 100/25 precipitated psychosis. Risperidone was changed to cloazapine without benefit in Parkinsonism. The rotigitine patch was introduced and increased to 8 mg/24 hours without aggravating her mental status and produced considerable improvement in Parkinsonian features. Conclusions: Rotigitine is worth exploring as a treatment for severe Parkinsonism in patients with schizophrenia.

Amavat in pediatric age group (multidisciplinary Ayurvedic approach): a single case study

2020 ◽  
Vol 8 (03) ◽  
Author(s):  
Mayuri Pawar
Keyword(s):  
Clinical Symptoms ◽  
Single Case ◽  
Treatment Protocol ◽  
Oral Intake ◽  
External Application ◽  
Pediatric Age Group ◽  
Patient Reported ◽  
Ayurvedic Treatment

Amavata is a chronic, progressive and crippling disorder caused due to generation of ama and its association with vitiated vata dosha and deposition in shleshma sthana (joints). Clinically resembling with Rheumatoid Arthirtis, it poses a challenge for the physician owing to its chronicity, morbidity and complications. The treasure of Ayurveda therapeutics has laid out detailed treatment line for amavata. A 13years old male patient reported to this hospital with pain and stiffness of metacarpophalangeal joints of right hand followed by pain in corresponding joints of other hand 1 year back. This was succeeded by pain and mild swelling on bilateral wrist, ankle and elbow joints. Based on clinical examination and blood investigations, diagnosis of amavata was made and Ayurvedic treatment protocol was advised with baluka sweda (sudation) as external application, rasnasaptak kashayam and dashmoolharitaki avaleha for oral intake for 30 days. The patient was asked for follow up every 15 days up to total of 45 days. Assessment was done subjectively based on clinical symptoms and blood investigations as objective parameters. There was substantially significant improvement and the patient felt relieved of the pain and inflammation of the joints after the treatment. This case study reveals the potential of Ayurvedic treatment protocol in management of amavata and may form a basis for further detailed study of the subject.

scholarly journals Geographic Information Systems and COVID-19: The Johns Hopkins University Dashboard

2020 ◽  
Author(s):  
BELMIRO N JOAO
Keyword(s):  
Information Systems ◽  
Single Case ◽  
Single Case Study ◽  
Epidemic Outbreak ◽  
Global Epidemic ◽  
Johns Hopkins University ◽  
Successful Case ◽  
Other Information

Abstract Background: This article presents a single case study on the development of a GIS for global monitoring of coronavirus (COVID-19). For such concepts presented about GIS, its use and evolution in epidemic events and a presentation of the context of the current coronavirus outbreak and the meaningless results of consolidating a panel with reliable data.Methods: A single case study of a GIS in continuous development with data sharing and comments from the scientific community was carried out. Because it is not a post-mortem analysis, or a follow-up to a successful case, it was not possible to use more rigorous and systematic approaches such as those used by Lee (1989) and Onsrud, Pinto and Azad (1992) for case studies in GIS.Results: The case study presents the results of the development of a control dashboard, as well as the availability of consolidated data made by researchers at Johns Hopkins University and who showed a reliable platform and a world reference for health comunity.Conclusions: Efforts to develop a dashboard and provide data on the coronavirus outbreak resulted in the immediate replication of several other information systems with different approaches (Power BI, R, Tableau), becoming a reference for any new global epidemic outbreak events.

scholarly journals Interoceptive Axes Dissociation in Anorexia Nervosa: A Single Case Study With Follow Up Post-recovery Assessment

2019 ◽  
Vol 9 ◽  
Author(s):  
Daniele Di Lernia ◽  
Silvia Serino ◽  
Nicoletta Polli ◽  
Chiara Cacciatore ◽  
Luca Persani ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Single Case ◽  
Single Case Study ◽  
Recovery Assessment

MANAGING CHALLENGING BEHAVIOUR IN AN ADULT WITH LEARNING DISABILITIES: THE USE OF LOW AROUSAL APPROACH

1998 ◽  
Vol 26 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Andrew McDonnell ◽  
Simon Reeves ◽  
Amanda Johnson ◽  
Alan Lane
Keyword(s):  
Learning Disabilities ◽  
Behaviour Change ◽  
Single Case ◽  
Challenging Behaviour ◽  
Single Case Study ◽  
Short Term ◽  
One Year ◽  
Challenging Behaviours

Behaviour change is often a desired outcome for carers and professionals who work with people with learning disabilities and challenging behaviours. Managing these behaviours in the short term is an important step towards this goal. This single case study presents the use of a low arousal approach in managing challenging behaviours in a young man labelled with severe challenging behaviour. This strategy focuses on the interaction of the carers with the client and how their approach has an important impact on the behaviour of the client. The study documents the incidents of challenging behaviour and shows a decline in their frequency from baseline over a one-year period. These gains were maintained at five-month follow-up. The implications for services of these findings are discussed.

ATTENTIONAL FOCUS AND FEAR OF BLUSHING: A CASE STUDY

1999 ◽  
Vol 27 (2) ◽  
pp. 153-164 ◽  
Author(s):  
Sandra Mulkens ◽  
Susan M. Bögelts ◽  
Peter J. de Jong
Keyword(s):  
Single Case ◽  
Attentional Focus ◽  
Single Case Study ◽  
Fear Avoidance ◽  
Differential Effects ◽  
Before And After ◽  
Fear Of Blushing

By means of a single case study, the effects of redirecting attention above exposure only on fear of blushing, avoidance, and idiosyncratic dysfunctional beliefs were tested. A social phobic patient with fear of blushing as the predominant complaint received sessions of Task Concentration Training (TCT) and Exposure in Vivo (EXP) alternately, after a steady baseline had been established. The treatment consisted of 14 individual sessions. Assessments were held before and after baseline, after treatment, after 4 weeks follow-up, and after 1-year follow-up. Continuous measurements were held throughout the treatment in order to measure the differential effects of TCT and EXP on fear, avoidance and beliefs. TCT and EXP together, turned out to be an effective treatment for fear of blushing: large effects were observed on all three outcome measurements. When differential effects are closely looked at, EXP seemed more effective in decreasing fear of blushing. However, the patient appeared to have used TCT strategies as well during the EXP weeks, which may have contributed to the favourable effects of EXP.

scholarly journals A Pilot Study of Concentrated EMDR: A Brief Report

2011 ◽  
Vol 5 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Earl Grey
Keyword(s):  
Pilot Study ◽  
Panic Disorder ◽  
Single Case ◽  
Single Case Study ◽  
Major Depressive ◽  
Treatment Frequency ◽  
Case Study Design ◽  
Psychotic Features

The current research used a quantitative single-case study design to investigate the effectiveness of eye movement desensitization and reprocessing (EMDR) treatment for a participant diagnosed with comorbid major depressive disorder (MDD), severe without psychotic features, and panic disorder with agoraphobia. Treatment frequency was three sessions per week, with twelve 90-minute reprocessing sessions provided over a period of 1 month; the study also evaluated this application of “concentrated EMDR.” At baseline, mean scores on the Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) were 49 and 38, and at 3-month follow-up, the scores had decreased to 8 and 7 respectively. The results of this pilot study indicate that concentrated EMDR may be effective in treating comorbid MDD and panic disorder with agoraphobia. The study also evaluated the application of concentrated EMDR, with treatment frequency increased from one session to three sessions per week. Twelve 90-minute reprocessing sessions were provided over a period of 1 month. Results show the apparent effectiveness of concentrated EMDR.

Case Study of Clinical Behavior Analysis for a 20-Year-Old Client With Emetophobia

2019 ◽  
Vol 18 (3) ◽  
pp. 163-174
Author(s):  
Takashi Mitamura
Keyword(s):  
Behavior Analysis ◽  
Single Case ◽  
Intervention Strategies ◽  
Single Case Design ◽  
Clinical Behavior Analysis ◽  
Clinical Behavior ◽  
Empirically Supported ◽  
Clinically Significant

This case study illustrates a clinical behavior analytic intervention for a female client with emetophobia, the fear of vomiting. Clinical behavior analysis is a recently developing branch of empirically supported psychotherapy, derived from behavior analysis. This case study presents modified case formulations and changed intervention strategies according to the results of repeated measuring. The intervention was six sessions and three gradual follow-up sessions; the effect of the intervention was monitored by a single-case design. The intervention strategies were changed from symptom-focused interventions, which are based on exposure, to value-focused gradual follow-up sessions. The client’s phobia and depression were alleviated through the intervention and gradual follow-up phases. Moreover, her value-based activities increased through the gradual follow-up phase. The Reliable Change Indexes (RCIs) were calculated to evaluate changes between the intervention and follow-up phases. There were large and clinically significant decreases on measures. The results highlight the utility of repeated measuring and importance of a value-focused approach.

scholarly journals Early Detection of t(8;21) Chromosomal Translocations during Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study

2010 ◽  
Vol 4 ◽  
pp. CMO.S6446 ◽  
Author(s):  
Walter Kleine Neto ◽  
Mariana Serpa ◽  
Sabri Saeed Sanabani ◽  
Patricia Torres Bueno ◽  
Elvira Deolinda Rodrigues Pereira Velloso ◽  
...  
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Genetic Screening ◽  
Treatment Initiation ◽  
Single Case ◽  
Promyelocytic Leukemia ◽  
Chromosomal Translocations ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment.

Cognitive behavioural therapy in the treatment of social skills deficits and social phobia in a man with an autism spectrum disorder: a single-case study

2016 ◽  
Vol 9 ◽  
Author(s):  
Mark A. Turner ◽  
Neil Hammond
Keyword(s):  
Social Skills ◽  
Social Anxiety ◽  
Social Phobia ◽  
Single Case ◽  
Behavioural Therapy ◽  
Autism Spectrum ◽  
Single Case Study ◽  
Cognitive Behavioural

AbstractAutism spectrum disorders (ASD) including high-functioning types such as Asperger's syndrome (AS) are diagnosed when there is evidence of a triad of qualitative impairments in social interaction, communication, and stereotyped/repetitive behaviours. It is not uncommon for these impairments to be accompanied by social anxiety. The present single-case study investigates the use of cognitive behavioural therapy (CBT) to treat a 47-year-old man who was assessed as having difficulties with social skills and social phobia in the context of a late diagnosis of AS. He received 20 h of CBT adapted for his AS in 15 sessions including a 1-month follow-up. Following a highly individualized formulation, treatment included modelling, role-playing, reinforcement, thought challenging, and behavioural experimentation. Results from five self-report measures showed continued improvements from the start of therapy to follow-up in social anxiety, global distress, depression and self-esteem. The client gave positive feedback about his experience of treatment. The case study is discussed with reference to limitations and some reflections for CBT in ASD.

Can the neuropsychological case-study approach be applied to schizophrenia?

1991 ◽  
Vol 21 (3) ◽  
pp. 661-673 ◽  
Author(s):  
T. Shallice ◽  
P. W. Burgess ◽  
C. D. Frith
Keyword(s):  
Cognitive Processes ◽  
Single Case ◽  
Cognitive Neuropsychology ◽  
Visual Agnosia ◽  
Study Approach ◽  
Frontal Lobe Lesions ◽  
Neurological Patients ◽  
Schizophrenic Patients ◽  
Attentional System

SYNOPSISNeuropsychological studies of schizophrenia typically apply a small number of tests to a large group of patients. This approach has at least two drawbacks. First, the heterogeneity of the condition will lead to group means which may not reflect the behaviour of any individual. Secondly, it is difficult to infer the nature of the underlying cognitive impairments from a small number of tests, since good performance on a particular test depends on many different cognitive processes. In these circumstances it is more appropriate to apply the methods of cognitive neuropsychology where a large number of tests are used on a single case. This approach has proved fruitful in the study of neurological patients. We have intensively studied 5 chronic schizophrenic patients. These patients varied greatly in terms of overall ability. However, all patients, whatever their overall ability, performed badly on tests sensitive to frontal lobe lesions. This result suggests impairment of the supervisory attentional system in these patients. In addition, one patient suffered from a visual agnosia.

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