scholarly journals P053: Adverse events and errors in trauma resuscitation: a systematic review

CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S83-S83
Author(s):  
A. Nikouline ◽  
A. Quirion ◽  
B. Nolan
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Search Strategy ◽  
High Stress ◽  
Trauma Resuscitation ◽  
Exclusion Criteria ◽  
Require Time ◽  
Outcome Differences ◽  
Failed Airway ◽  
Key Terms

Introduction: Trauma resuscitations are plagued with high stress and require time sensitive and intensive interventions. It is a landscape that is a perfect hot bed for clinical errors and adverse events for patients. We sought to describe the adverse events and errors that occur during trauma resuscitation and any associated outcomes. Methods: Medline was searched for a combination of key terms involving trauma resuscitation, adverse events and errors from January 2000 to May 2019. Studies that described adverse events or errors in initial adult trauma resuscitations were included. Two reviewers analyzed papers for inclusion and exclusion criteria with a third reviewer for any discrepancies. Descriptions of errors, adverse events and associated outcomes were collated and presented. Results: A total of 3,462 papers were identified by our search strategy. 18 papers met our inclusion and exclusion criteria and were selected for full review. Adverse events and errors reported in trauma resuscitation included missed injuries, aspiration, failed airway, and deviation from protocol. Rates of adverse events and errors were reported where applicable. Mortality outcomes or length of stay were not directly correlated to adverse events or errors experienced in the trauma resuscitation. Conclusion: Our study highlights the predominance of adverse events and errors experienced during initial trauma resuscitation. We described a multitude of adverse events and errors and their rates but further study is needed to determine outcome differences for patients and possibility for quality improvement.

Adverse Effects of Natural Products: A Brief Pre-Systematic Review

2020 ◽  
Vol 01 ◽  
Author(s):  
Carla Pires ◽  
Ana Fernandes
Keyword(s):  
Systematic Review ◽  
Adverse Event ◽  
Natural Products ◽  
Adverse Events ◽  
In Vitro Study ◽  
Google Scholar ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Meta Analyses

Background: Natural products are commonly used for treating health problems. These products may be associated with adverse events, which are defined as "noxious and unintended response to a medicinal product" by the European Medicine Agency. Objectives: To identify studies describing at least one adverse event (or with potential to promote an adverse event) related to the use of natural products, as well as to describe the involved product(s) and adverse event(s). Methods: A pre-systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Keywords: "natural product(s)" and ["adverse drug reaction(s)" or "adverse effect(s)"]. Screened databases: PubMed, SciELO, DOAJ and Google Scholar. Inclusion criteria: papers describing at least one adverse event associated with the use of natural products and published between 2017 and 2019. Exclusion criteria: Repeated studies, reviews and papers written in other languages than English, Portuguese, French or Spanish. Results: 104 studies were identified (20 PubMed; 0 SciELO; 2 DOAJ; 82 Google Scholar), but only 10 were selected (4 PubMed and 6 Google Scholar): 1 in-vitro study; 2 non-clinical studies, 1 study reporting in-vitro and clinical data and 5 studies were cases reports. Globally, 997 reports of adverse drug reactions with natural products were identified, mainly non-severe cases. Conclusion: Since a limited number of studies was found, we conclude that adverse events due to natural products may be underreported, or natural products may have a good safety profile. This review contributes for assuring the safety of natural products consumers, by evaluating the knowledge/information on the potential adverse events and interactions of these products.

Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta-analysis

Transfusion ◽  
2018 ◽  
Vol 59 (2) ◽  
pp. 806-824 ◽  
Author(s):  
Jeffrey Yates ◽  
Iris Perelman ◽  
Simonne Khair ◽  
Joshua Taylor ◽  
Jacinthe Lampron ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Tranexamic Acid ◽  
Meta Analysis ◽  
Exclusion Criteria

scholarly journals Prevalence of the Genus Propionibacterium in Primary and Persistent Endodontic Lesions: A Systematic Review

2020 ◽  
Vol 9 (3) ◽  
pp. 739 ◽  
Author(s):  
Mario Dioguardi ◽  
Mario Alovisi ◽  
Vito Crincoli ◽  
Riccardo Aiuto ◽  
Giancarlo Malagnino ◽  
...  
Keyword(s):  
Systematic Review ◽  
Propionibacterium Acnes ◽  
Meta Analysis ◽  
Secondary Outcome ◽  
Exclusion Criteria ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Endodontic Infections ◽  
Outcome Differences ◽  
Present Systematic Review

Propionibacterium are anaerobic/aero-tolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections. The data in the literature on the prevalence of Propionibacterium are conflicting, and there are studies that report conflicting data on the prevalence in primary and secondary endodontic infections. This review aims to clarify the prevalence of bacteria of the genus Propionibacterium in endodontic lesions. The present systematic review work was performed on the basis of the Prisma protocol. A search was carried out on the PubMed and Scopus databases with the use of keywords. The research produced 410 records, which, after the elimination of the overlaps and the application of the inclusion and exclusion criteria, led to a number of 36 included articles divided by the three outcomes. The first outcome concerns prevalence of bacteria of the genus Propionibacterium in primary and secondary endodontic lesions. The secondary outcome, differences in the prevalence of bacteria of the genus Propionibacterium between primary endodontic infections and secondary endodontic infections. The tertiary outcome, differences in the prevalence of Propionibacterium Acnes compared to Propionibacterium propionicum in endodontic infections. The results of the meta-analysis show that the genus Propionibacterium bacteria are more prevalent in secondary endodontic infections and that P. acnes has a higher prevalence than P. propionicum.

scholarly journals Voice-Related Patient-Reported Outcome Measures: A Systematic Review of Instrument Development and Validation

2017 ◽  
Vol 60 (1) ◽  
pp. 62-88 ◽  
Author(s):  
David O. Francis ◽  
James J. Daniero ◽  
Kristen L. Hovis ◽  
Nila Sathe ◽  
Barbara Jacobson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Effectiveness ◽  
A Priori ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Measurement Properties ◽  
Exclusion Criteria ◽  
Patient Reported ◽  
Development And Validation ◽  
Key Terms

Purpose The purpose of this study was to perform a comprehensive systematic review of the literature on voice-related patient-reported outcome (PRO) measures in adults and to evaluate each instrument for the presence of important measurement properties. Method MEDLINE, the Cumulative Index of Nursing and Allied Health Literature, and the Health and Psychosocial Instrument databases were searched using relevant vocabulary terms and key terms related to PRO measures and voice. Inclusion and exclusion criteria were developed in consultation with an expert panel. Three independent investigators assessed study methodology using criteria developed a priori. Measurement properties were examined and entered into evidence tables. Results A total of 3,744 studies assessing voice-related constructs were identified. This list was narrowed to 32 PRO measures on the basis of predetermined inclusion and exclusion criteria. Questionnaire measurement properties varied widely. Important thematic deficiencies were apparent: (a) lack of patient involvement in the item development process, (b) lack of robust construct validity, and (c) lack of clear interpretability and scaling. Conclusions PRO measures are a principal means of evaluating treatment effectiveness in voice-related conditions. Despite their prominence, available PRO measures have disparate methodological rigor. Care must be taken to understand the psychometric and measurement properties and the applicability of PRO measures before advocating for their use in clinical or research applications.

scholarly journals Pneumocystis Pneumonia and Acute Myeloid Leukemia: A Systematic Review

2021 ◽  
Author(s):  
Atousa Hakamifard ◽  
Shervin Shokouhi ◽  
Masoud Mardani ◽  
Nariman Mosaffa ◽  
Hamed Azhdari Tehrani
Keyword(s):  
Systematic Review ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Search Strategy ◽  
Pneumocystis Pneumonia ◽  
Bone Marrow Suppression ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Immunological Mechanism ◽  
Acute Myeloid

Abstract: Background: Pneumocystis pneumonia (PCP) incidence in acute myeloid leukemia (AML) patients have not been well described and some studies have shown the risk of this infection in these groups of patients. In this systematic review, we reviewed the published studies about PCP in AML to evaluate the PCP incidence and outcomes in these patients and then focuses on its immunological mechanism. Method: All articles reviewed in this collection are from recruited sites: PubMed and Embase databases. No time limit was considered for article searching. The following keywords were used: (“Pneumonia, Pneumocystis” OR Pneumocystis Pneumonia” OR “Pneumocystis jirovecii”), AND (“leukemia, myeloid, acute OR acute myeloid leukemia”). Our search strategy yielded 356 articles. After implementing the exclusion and inclusion criteria, the final papers were selected and reviewed. Result: By our search, 356 articles were found (316 in PubMed and 40 in Embase). After the implementation of inclusion and exclusion criteria, seven papers remained. A total of seven articles with a total number of 41 patients were included. Conclusion: Affected patients appear to have a clear resistance to PCP infection despite chemotherapy and bone marrow suppression due to the preservation of a specific immunological milieu in the lung. In fact, may be due to immunological stability of the lungs that remains intact. Further studies are needed.

scholarly journals Difficulties in resuscitating adult skeletal injury and trauma: a systemic review

2017 ◽  
Vol 4 (10) ◽  
pp. 3206
Author(s):  
Turki Abdullah S. Al-ajmi ◽  
Abdullah Salah Al-hussain ◽  
Mohammed Fuad Al-Abdulqader
Keyword(s):  
Systematic Review ◽  
Functional Outcomes ◽  
Data Extraction ◽  
Systemic Review ◽  
Trauma Resuscitation ◽  
Exclusion Criteria ◽  
Factors Affecting ◽  
Skeletal Injury ◽  
Second Stage ◽  
Critical Aspects

Background: Trauma resuscitations are complicated, high-risk, and time-sensitive actions that need the coordination of different specialists arriving from multiple areas in the hospital. This systematic review aimed to understand the main key challenges of trauma resuscitations using a broad search in various database.Methods: A systematic review of published articles between the years 2000 and 2016 was conducted using different electronic databases such as PubMed, Medline and Embase to identify studies evaluating trauma resuscitations challenges. Different keywords were used in this study to recognize relevant articles. The titles of all articles were scanned in the first stage. Irrelevant articles were omitted and the abstracts of the rest articles were reviewed in the second stage. Finally, the full text of all articles which met the inclusion and exclusion criteria were reviewed and a data extraction sheet was made to summarize all the articles. Data were analyzed descriptively.Results: Twenty studies were reviewed including; RCT (3 studies), QRCT (5 studies), and descriptive study (12 studies). The results showed that there are four main trauma resuscitation challenges including pre-hospital challenges, error-related challenges, equipment and technical challenges, and finally general challenges.Conclusions: Trauma resuscitation is one of the most critical aspects of emergency care. It is necessary to promote resuscitation care and focus on patient outcomes in terms of mortality and more importantly, functional outcomes. Considering these main factors affecting trauma resuscitation will improve patients’ outcomes and help those who are engaged in providing services.

scholarly journals Timing of M. tuberculosis exposure explains variation in BCG effectiveness: A systematic review and meta-analysis

2020 ◽  
Author(s):  
James M Trauer ◽  
Andrew Kawai ◽  
Anna Coussens ◽  
Manjula Datta ◽  
Bridget M Williams ◽  
...  
Keyword(s):  
Systematic Review ◽  
Search Strategy ◽  
Latitudinal Gradient ◽  
Meta Analysis ◽  
Early Exposure ◽  
Exclusion Criteria ◽  
High Burden ◽  
Bcg Vaccination ◽  
Explanatory Hypothesis

AbstractBackgroundThe variable efficacy observed in studies of BCG vaccination is incompletely explained by currently accepted hypotheses, such as latitudinal gradient in non-tuberculous mycobacteria exposure. We investigated heterogeneity in BCG vaccination in the context of participant demography, diagnostic approach and TB-related epidemiological context.MethodsWe updated previous systematic reviews of the effectiveness of BCG vaccination to 31st December 2018. We employed an identical search strategy and inclusion/exclusion criteria to past reviews, but reclassified several studies and developed an alternative classification system.ResultsOf 21 included trials, those recruiting neonates and children aged under five were consistent in demonstrating considerable protection for several years. Trials in high-burden settings with shorter follow-up also showed considerable protection, as did most trials in settings of declining burden with longer follow-up. However, the few trials performed in high-burden settings with longer follow-up showed no protection, sometimes with higher case rates in the vaccinated than the controls in the later follow-up period.ConclusionsThe most plausible explanatory hypothesis is that BCG protects against TB that results from exposure shortly after vaccination. However, risk is equivalent or increased when exposure occurs later from vaccination, a phenomenon which is predominantly observed in adults in high-burden settings with longer follow-up. In settings of declining burden, most exposure occurs shortly following vaccination and the sustained protection thereafter represents continued protection against this early exposure. By contrast, in settings of continued intense transmission, initial protection subsequently declines due to repeated exposure to M. tuberculosis or other pathogens.

Interprofessional Practice and Education Through 100 Years of Families in Society

2020 ◽  
Vol 101 (2) ◽  
pp. 119-131
Author(s):  
Teri Kennedy
Keyword(s):  
Systematic Review ◽  
Social Work ◽  
Social Services ◽  
Interprofessional Practice ◽  
Exclusion Criteria ◽  
Education Practice ◽  
Work Education ◽  
Key Terms ◽  
Quantitative And Qualitative Methods ◽  
Extensive List

This article explores 100 years of interprofessional practice and education (IPE) through the archives of Families and Society: The Journal of Contemporary Social Services. A journal-specific archival and systematic review employing quantitative and qualitative methods identifies early references to, and frequency of, terms and meanings associated with IPE; examines meanings associated with terms describing interprofessional interactions; and explores related contexts, settings, and populations served. Articles were searched using key terms from two scoping IPE reviews and narrowed based on inclusion and exclusion criteria. An Excel© spreadsheet was prepared using descriptive, qualitative, and coded items. Findings revealed early references to IPE-related concepts, an expanded list of classifications and descriptions of interprofessional interactions, and an extensive list of practice settings and populations served through IPE-related activities. Implications for social work education, practice, policy, and research are addressed.

scholarly journals Are mental disorders related to disbelief in free will? A systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria E. Moreira-de-Oliveira ◽  
Gabriela B. de Menezes ◽  
Samara dos Santos-Ribeiro ◽  
Luana D. Laurito ◽  
Ana P. Ribeiro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Free Will ◽  
Search Strategy ◽  
Web Of Science ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Study Selection

Abstract Background The nature and existence of free will have been debated for centuries. Since some psychiatric disorders are known to interfere with one’s ability to control their actions and thoughts (e.g., schizophrenia), the investigation of the psychiatric facet of free will beliefs seems to be relevant. In this systematic review, we were interested in clarifying if and how having a mental disorder affects individuals’ beliefs in free will by comparing psychiatric vs. non-psychiatric samples. Methods A systematic search of MEDLINE, Web of Science, EMBASE, and PsycINFO databases was performed between 04 and 09 November 2020. The search strategy included “free will” and related constructs and terms related to DSM-5 mental disorders characterized by psychotic, compulsive, avoidant, or impulsive symptoms. Eligible designs of studies included case-control and cohort studies. Study selection took place in committee meetings consisting of six researchers. Quality assessment of the selected studies was performed through the Joanna Briggs Institute Appraisal Checklist for Case Control Studies. Results After removing duplicates, a total of 12,218 titles/abstracts were screened. Inclusion and exclusion criteria were followed, and three articles were eventually selected. Conclusions It is not possible to provide unequivocal confirmation that having a mental disorder can or cannot affect someone’s belief in free will. Studies with different mental disorders should be conducted in this field. Systematic review registration PROSPERO CRD42018109468.

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