scholarly journals P058: Morbid obesity association with return of spontaneous circulation from sudden cardiac arrest treated in a large, urban EMS system in the United States

CJEM ◽  
2017 ◽  
Vol 19 (S1) ◽  
pp. S97-S98
Author(s):  
J.M. Goodloe ◽  
L.D. Vinson ◽  
M.L. Cox ◽  
B.D. Burns
Keyword(s):  
United States ◽  
Morbid Obesity ◽  
Cardiac Arrest ◽  
Adult Population ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Spontaneous Circulation ◽  
Contributing Factors ◽  
Return Of Spontaneous Circulation ◽  
Specific Analysis

Introduction: Patient co-morbidities contribute to survivability from out-of-hospital sudden cardiac arrest. Many studies have been conducted regarding contributing factors to sudden cardiac arrest survival, though very few studies have been published detailing specific analysis of morbid obesity association with return of spontaneous circulation (ROSC) in adults treated by paramedics. Methods: Adults in sudden cardiac arrest with resuscitation initiated, including at least one defibrillation, between July 1, 2016 and December 1, 2016 were enrolled. Due to an increasing prevalence of morbid obesity in the United States adult population, a novel defibrillation strategy, involving weight-based joule settings and double sequential external defibrillation (DSED) was initiated in June 2016. As exact body weight is logistically difficult to obtain in the EMS care environment, a paramedic-estimated weight at the time of resuscitation to be 100 kg or greater was deemed representative of “morbid obesity” for this analysis. All resuscitations were reviewed from electronic medical records (EMRs) completed by treating paramedics, alongside telemetry and defibrillation events recorded, transmitted, and analyzed in proprietary software (CODE-STAT, Physio-Control Corporation, Redmond, WA). ROSC was determined from both paramedic and hospital clinician EMRs reviewed by a paramedic researcher. Results: During the 5 month study period, paramedics involved treated 133 adults in sudden cardiac arrest involving perceived ventricular fibrillation that was treated with at least one defibrillation. 49/90 (54.4%) with weight <100 kg as estimated by paramedics at the time of resuscitative care achieved at least transient ROSC. Only 17/43 (39.5%) with estimated weight ≥100 kg achieved any ROSC, despite paramedics authorized to perform defibrillations at higher joule energy settings for such weight. The OR for ROSC if <100 kg estimated weight is 1.83 (95% CI 0.87-3.83), though given limited sample size p=0.11. Conclusion: While survival from out-of-hospital sudden cardiac arrest in adults is multi-factorial, the presence of morbid obesity, defined as estimated weight ≥100 kg, trends towards less ROSC. Continued community health efforts to decrease the prevalence of morbid obesity in the adult population may confer improved ability to survive out-of-hospital sudden cardiac arrest.

Abstract 140: Prehospital Protocols for Post-Return of Spontaneous Circulation Care Are Highly Variable

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Justin L Benoit ◽  
Jason T McMullan ◽  
Michael F Spigner ◽  
James J Menegazzi
Keyword(s):  
United States ◽  
Cardiac Arrest ◽  
A Priori ◽  
The United States ◽  
Spontaneous Circulation ◽  
Data Abstraction ◽  
Prehospital Treatment ◽  
Return Of Spontaneous Circulation ◽  
Traumatic Cardiac Arrest ◽  
Hospital Transport

Introduction: Up to 40% of out-of-hospital cardiac arrest patients will re-arrest in the immediate post-return of spontaneous circulation (post-ROSC) period, and re-arrest is associated with decreased survival. Cardiac arrest guidelines are equivocal regarding what post-ROSC care should be provided in the prehospital setting and when hospital transport should occur. Prehospital protocols must balance the benefit of time-dependent hospital-based care with the risk of early re-arrest. We sought to describe current prehospital protocols for post-ROSC care. Hypothesis: Prehospital protocols for post-ROSC care will be variable. Methods: A single trained abstractor systematically reviewed a purposive sample of prehospital protocols for adult non-traumatic cardiac arrest from the United States using an a priori standardized data abstraction form. Protocols were either stand-alone or integrated into intra-arrest care. Exclusion criteria were non-911 ground transport agencies and protocols not revised since the 2015 guideline update. All protocols were publically available via the Internet. Data abstraction was conducted in May 2019. The number of protocols that met pre-defined criteria were counted and summarized. Results: We identified and reviewed 82 prehospital protocols from 46 states and the District of Columbia. Seven protocols were excluded due to the revision date, leaving 75 protocol included in the study (Table). Six protocols (8%) provide no guidance on prehospital post-ROSC care. ECG acquisition (63/75 [84%]) and transport to specific post-ROSC hospitals (overall 55/75 [73%], but 22/55 [40%] are only if STEMI present) are common but not universal. Only 9 (12%) provide any guidance on when to initiate transport post-ROSC, with 4 (5%) requiring a post-ROSC stabilization period of at least 5 minutes prior to transport. Conclusion: Prehospital treatment and transport protocols for post-ROSC care are highly variable across the United States.

Out-of-Hospital Resuscitation: Have We Gone Too Far?

2006 ◽  
Vol 21 (6) ◽  
pp. 445-450 ◽  
Author(s):  
Corita Grudzen
Keyword(s):  
Cardiac Arrest ◽  
Prehospital Care ◽  
Sudden Cardiac Arrest ◽  
Hospital Setting ◽  
The United States ◽  
Spontaneous Circulation ◽  
Emergency Medical ◽  
Clinical Scenarios ◽  
Life Sustaining Treatment ◽  
Future Policy

AbstractAmericans are living longer and are more likely to be chronically or terminally ill at the time of death. Although surveys indicate that most people prefer to die at home, the majority of people in the United States die in acute care hospitals. Each year, approximately 400,000 persons suffer sudden cardiac arrest in the US, the majority occurring in the out-of-hospital setting. Mortality rates are high and reach almost 100% when prehospital care has failed to restore spontaneous circulation. Nonetheless, patients who receive little benefit or may wish to forgo life-sustaining treatment often are resuscitated. Risk versus harm of resuscitation efforts can be differentiated by various factors, including cardiac rhythm. Emergency medical services policy regarding resuscitation should consider its utility in various clinical scenarios. Patients, family members, emergency medical providers, and physicians all are important stakeholders to consider in decisions about out-of-hospital cardiac arrest. Ideally, future policy will place greater emphasis on patient preferences and quality of life by including all of these viewpoints.

Abstract 246: Therapeutic Hypothermia Mimicking Peptide Administration During Cardiopulmonary Resuscitation Improved Cardiac Arrest Survival in Swine

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_4) ◽  
Author(s):  
Matt Oberdier ◽  
Jing Li ◽  
Dan Ambinder ◽  
Xiangdong Zhu ◽  
Sarah Fink ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Venous Blood ◽  
Plasma Concentrations ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Rapid Onset ◽  
Spontaneous Circulation ◽  
Control Group ◽  
Swine Model

Background: Out-of-hospital sudden cardiac arrest is a leading cause of death in the United States, affecting over 350,000 people per year with an overall survival rate around 10%. CPR, defibrillation, and therapeutic hypothermia are common resuscitation strategies, but hypothermia is difficult to implement timely to achieve survival benefit. A cell-permeable peptide TAT-PHLPP9c has been shown to alter metabolic pathways similar to hypothermia, and decreases the release of two biomarkers, taurine and glutamate, during the high osmotic stress of heart stunning and brain injury in a mouse arrest model. Hypothesis: TAT-PHLPP9c, given during CPR, enhances 24-hour survival in a swine ventricular fibrillation (VF) model. Methods: In 14 (8 controls and 6 treated) sedated, intubated, and mechanically ventilated swine, after 5 min of VF, ACLS with vest CPR and periodic defibrillations was performed. Venous blood samples were collected at baseline, after 2 min of CPR, and at 2 and 30 min after return of spontaneous circulation (ROSC). The animals were survived up to 24 hrs and plasma samples were analyzed for glutamate and taurine in 2 controls and 1 animal given peptide. Results: Three of the control animals had ROSC, but none survived for 24 hrs, while 4 of 6 treated animals achieved neurologically intact survival at 24 hrs (p < 0.02). Compared to baseline, both taurine and glutamate plasma concentrations increased in the control group, but the increase was reduced substantially by the peptide treatment at 30 min after ROSC (Figure). Conclusion: The use of the cooling mimicking peptide TAT-PHLPP9c administered during CPR significantly improved 24-hour survival in this swine model of cardiac arrest. It reduced the increase of cerebral and myocardial metabolic biomarkers, which encourages utilizing a strategy of cell-permeable peptides for intravenous administration for more rapid onset of hypothermia-like salutary effects than are possible with current CPR cooling devices.

Abstract 17127: Sports-Related Sudden Cardiac Arrest: Comparison of Survival Outcomes in Europe versus the United States

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Eloi Marijon ◽  
Audrey Uy-Evanado ◽  
Florence Dumas ◽  
Carmen Teodeorescu ◽  
Kyndaron Reinier ◽  
...  
Keyword(s):  
United States ◽  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Response Times ◽  
Survival Rates ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Population Based ◽  
Sports Activity ◽  
Bystander Cardiopulmonary Resuscitation

Background: Sports-related sudden cardiac arrest (sport SCA) has always attracted attention and the United States and European Union have developed divergent strategies for prevention over the last decade; notably regarding screening of younger athletes but also for SCA prevention in middle-aged and senior individuals. In this context, the extent to which outcomes of sports SCA differ between Europe and the USA have not been characterized. Methods: SCA cases aged 15-75 years were identified in two large prospective, population-based SCA programs, one in the Paris region (Paris-SDEC) and the other in a Northwestern US metro region (Oregon-SUDS) between 2002 and 2012. Cases of SCA, occurring during sports activity were compared between the two regions. Results: Of the 7,357 cases studied, 290 (4%) occurred during sports, with very similar proportions in both regions: 86 out of 1,894 (4.5%) in Oregon and 204 out of 5,463 (3.8%) in Paris. Subjects’ characteristics of cases in both programs were very similar (Paris vs. Oregon, respectively, for all results following), regarding age (50.7±14 vs. 50.4±13 years, P=0.55), male proportion (94%vs. 92%, P=0.53), past medical history of ≥2 cardiovascular risk factors (16% vs. 23%, P=0.16) and/or heart disease (10% vs. 8%, P=0.55). There was a high proportion of witnessed events in both populations (89% vs. 90%, P=0.94). However, we observed significant differences with more bystander cardiopulmonary resuscitation in Paris (63% vs. 48%, P=0.02), faster response time in Oregon (8.3±6 vs. 6.9±4 min, P=0.05), and more initially shockable rhythms in Oregon (52% vs. 70%, P=0.006). Overall, resuscitation outcomes were very similar for return of spontaneous circulation (26% vs. 33%, P=0.21) and survival to hospital discharge (27% vs. 26%, P=0.80). Conclusions: On either side of the Atlantic, burden and characteristics of sports-related SCA are very similar. Survival rates are approximately one in four cases. Optimizing bystander cardiopulmonary resuscitation rates and emergency response times could further improve outcomes. Deployment of uniform, effective strategies for screening and prevention are likely to make the greatest impact on sports SCA.

scholarly journals P059: Paramedic compliance with a novel defibrillation strategy in a large, urban EMS system in the United States

CJEM ◽  
2017 ◽  
Vol 19 (S1) ◽  
pp. S98
Author(s):  
J.M. Goodloe ◽  
L.D. Vinson ◽  
M.L. Cox ◽  
B.D. Burns
Keyword(s):  
Cardiac Arrest ◽  
Ventricular Fibrillation ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Energy Strategy ◽  
Specific Analysis ◽  
Hands On ◽  
Software Code

Introduction: Emergency Medical Services (EMS) care confers distinct impact upon survivability from sudden cardiac arrest. Many studies have been conducted regarding EMS interventions for cardiac arrest, though fewer studies have been published detailing specific analysis of paramedic compliance with standing orders, particularly those involving a novel energy strategy in defibrillation. Methods: Adults in sudden cardiac arrest with resuscitation initiated, including at least one defibrillation, between July 1, 2016 and December 1, 2016 were enrolled. Education on a novel defibrillation strategy, involving weight-based joule settings and double sequential external defibrillation (DSED) was delivered in classroom and internet-accessed settings. Paramedics then performed hands-on practice in DSED. All resuscitations were reviewed from electronic medical records (EMRs) completed by treating paramedics, alongside telemetry and defibrillation events recorded, transmitted, and analyzed in proprietary software (CODE-STAT™, Physio-Control Corporation, Redmond, WA). All ECGs and defibrillation events were reviewed by an emergency physician to determine energy settings used by paramedics for determining the accuracy of compliance with protocol-based standing orders. Results: During the 5 month study period, the paramedics involved treated 133 adults in sudden cardiac arrest involving perceived ventricular fibrillation that was treated with at least one defibrillation. 76/90 (84.4%) with estimated weight &lt;100 kg were treated with correct joule settings, though only 7/43 (16.3%) with estimated weight ≥100kg received all defibrillations at 360J as protocol-specified. 26/44 (59.1%) in refractory ventricular fibrillation, defined as requiring a fourth defibrillation, received DSED as protocol-specified. Conclusion: Paramedics, when specifically trained on a novel defibrillation strategy, involving both weight-based joule settings and use of DSED for refractory ventricular fibrillation, are inconsistently able to quickly and successfully incorporate that strategy in EMS resuscitation care. Further educational endeavours are warranted to achieve higher defibrillation strategy protocol compliance.

scholarly journals Return of spontaneous circulation and heart rhythm during the first analysis of the heart electrical activity

2019 ◽  
Vol 18 (3) ◽  
pp. 147-150
Author(s):  
Sebastian Kowalski ◽  
Adrian Moskal ◽  
Karolina Żak-Kowalska ◽  
Mariusz Goniewicz
Keyword(s):  
Cardiac Arrest ◽  
Electrical Activity ◽  
Statistical Significance ◽  
Sudden Cardiac Arrest ◽  
Heart Rhythm ◽  
Spontaneous Circulation ◽  
Return Of Spontaneous Circulation ◽  
Heart Electrical Activity ◽  
First Moment ◽  
The Relationship

AbstractIntroduction. Return of spontaneous circulation (ROSC) of a patient with cardiac arrest is the main goal of carrying out cardiopulmonary resuscitation.Aim. Evaluation of frequency of return of spontaneous circulation depending on the heart rhythms in the first moment of heart electrical activity.Material and methods. Analysis of 105 cases of sudden cardiac arrest in out-of-hospital conditions on the premises of Brzozow Emergency Medical Service from September 2016 to the end of February 2018. The data was collected from intervention medical cards and medical rescue procedure cards. Statistical analysis was carried out using STATISTICA software. Statistical significance was assumed to be p<0.05.Results. Sudden cardiac arrest in the analysed group applied to 62.9% of men. Return of spontaneous circulation was achieved only in 16 out of 105 cases (15.2%) of sudden cardiac arrest. The analysis has indicated that ROSC was successful among 66.67% of patients, who during the first analysis of the rhythm, represented cardiac arrest in VF/pVT, what constituted 75% of all ROSC cases in the analysed group. Comparison between ROSC and rhythm during the first evaluation of the rhythm showed statistical significance (p=0.00). Statistical significance was also shown in the relationship between ROSC and the average age of the patient (p=0.0155).Conclusions. Sudden cardiac arrest, when diagnosed in the first analysis of the rhythm VF/pVT, has bigger chances for return of spontaneous circulation than it has in other rhythms.

scholarly journals Out of Hospital Pediatric Cardiac Arrest

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
United States ◽  
Overall Survival ◽  
Cardiac Arrest ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Annual Incidence ◽  
International Data ◽  
Therapeutic Tools ◽  
Hospital Pediatric ◽  
Hospital Cardiac Arrest

Out of hospital cardiac arrest in the pediatric patient is an uncommon event [1]. Exact incidence of occurrence in the United States is difficult to determine as epidemiologic reporting is not nationally mandated. Previous data has suggested an annual incidence of 0.8- 6.0 per 100,000 patients [2]. International data has helped answer this question suggesting the annual incidence of pediatric sudden cardiac arrest of 0.23 percent [3]. Out of hospital cardiac arrest can be due to a variety of insults and accordingly, outcomes vary depending upon the initial insult. Overall survival in children aged 0-17 years old is approximately 7.2 percent [1] to 8.3 percent [4]. The purpose of this article is to review present therapeutic tools and recommendations available to the healthcare provider.

Survival trends in the United States following exercise-related sudden cardiac arrest in the youth: 2000–2006

Heart Rhythm ◽  
2008 ◽  
Vol 5 (6) ◽  
pp. 794-799 ◽  
Author(s):  
Jonathan A. Drezner ◽  
Jordan S.D.Y. Chun ◽  
Kimberly G. Harmon ◽  
Linette Derminer
Keyword(s):  
United States ◽  
Cardiac Arrest ◽  
Sudden Cardiac Arrest ◽  
The United States

Forensic Assessment of Natural Unexpected Cardiovascular Death

2017 ◽  
pp. 322-339
Author(s):  
Gulnaz T. Javan ◽  
Sheree J. Finley ◽  
Sait Ozsoy
Keyword(s):  
United States ◽  
Cardiac Arrest ◽  
Criminal Justice ◽  
Cardiovascular System ◽  
Cardiac Death ◽  
Sudden Cardiac Arrest ◽  
The United States ◽  
Cardiovascular Death ◽  
Forensic Assessment ◽  
Molecular Analyses

In the United States, sudden unexpected deaths attributable to diseases of the cardiovascular system account for almost 50% of all natural deaths with up to 600,000 deaths per year. Over the past decade, substantial developments have been made to provide definitive determinations in the diagnosis of cardiac death for adjudication in the criminal justice system and closure for decedent's families. In order to make postmortem diagnostic determinations, coordinated multidisciplinary efforts include collaboration between clinical and forensic pathologists. Forensic protocols include examination of the heart, histological sampling, toxicology testing, and molecular analyses. Lack of alternative diagnoses generally prompts pathologists to report sudden cardiac arrest as the main cause of death in many cases even though the accuracy of this finding might be in question; therefore, a forensic pathologist should examine unexplained cases of death in more depth to avoid this possible misdiagnosis.

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