scholarly journals Tranexamic Acid for Epistaxis–A Promising Treatment That Deserves Further Study

CJEM ◽  
2015 ◽  
Vol 18 (1) ◽  
pp. 72-73 ◽  
Author(s):  
David Clinkard ◽  
David Barbic
Keyword(s):  
Randomized Controlled Trial ◽  
Tranexamic Acid ◽  
Rapid Method ◽  
Bleeding Time ◽  
Controlled Trial ◽  
Clinical Question ◽  
Randomized Controlled ◽  
Promising Treatment ◽  
Topical Tranexamic Acid ◽  
Injectable Form

Clinical QuestionDoes the application of topical tranexamic acid reduce bleeding as compared to anterior packing?Article ChosenZahed R, Moharamzadeh P, Alizadeharasi S, et al. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med 2013;31(9):1389-92.ObjectivesTo determine if topically applied tranexamic acid reduces bleeding time in epistaxis.

scholarly journals Adjunctive IV tranexamic acid versus topical tranexamic acid application of the placental bed for prevention of postpartum hemorrhage in women with placenta previa: a randomized controlled trial

2017 ◽  
Vol 6 (12) ◽  
pp. 5205
Author(s):  
Nahla W. Shady ◽  
Hany F. Sallam
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Caesarean Delivery ◽  
Placenta Previa ◽  
Controlled Trial ◽  
Acid Group ◽  
Randomized Controlled ◽  
Group I ◽  
Topical Tranexamic Acid

Background: Placenta previa one of the famous etiology of excessive blood loss during and after cesarean section. The objective of this study was to determine the effect of prophylactic adjunctive IV versus topical tranexamic acid (TA) on calculated and measured blood loss during and after caesarean section due to placenta previa compared with standard IV oxytocin alone.Methods: In this double-blind randomized controlled trial, 120 women were undergoing caesarean delivery for placenta previa (PP) were randomly allocated to receive 10 IU oxytocin IV after placental delivery, or receive 1 gm tranexamic acid IV just before skin incision plus 10 IU oxytocin IV after placental delivery or received 10 IU oxytocin IV after placental delivery plus 2 gm topical tranexamic acid applied on placental bed. The main outcome was to measure blood loss during and 4-hour post caesarean delivery.Results: 120 women were enrolled (n = 40 in each group). Both groups of women received IV tranexamic acid (Group II) and topical tranexamic acid (Group III) showed great reduction in intraoperative and 4 hours post-operative blood loss compared with (Group I) which received 10 IU oxytocin only (P = 0.0001, 0.0001, 0.0001, 0.0001), so the overall estimated blood loss in group II and III showed highly reduction compared with group I (P = 0.0001, 0.0001).Conclusions: Prophylactic adjunctive TA topical application on the placental bed or iv administration reduces blood loss during and after caesarean delivery in women with a placenta previa. novel application of topical tranexamic acid on the placental bed is effective in reduce intraoperative and postoperative bleeding in comparison with IV route with elimination of theoretical risk of thrombi embolism complication with IV rout.

scholarly journals Topical tranexamic acid for the treatment of epistaxis in patients using antiplatelet agents

CJEM ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 774-776 ◽  
Author(s):  
Mark Sanderson ◽  
James Powell ◽  
Eddy Lang
Keyword(s):  
Randomized Controlled Trial ◽  
Tranexamic Acid ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Antiplatelet Agents ◽  
Nasal Packing ◽  
Randomized Controlled ◽  
Secondary Outcomes ◽  
Topical Tranexamic Acid ◽  
Time Of Intervention

ABSTRACTClinical questionDoes the addition of topical tranexamic acid to anterior nasal packing decrease bleeding in patients with epistaxis who are taking antiplatelet medications?Article chosenZahed R, Jayazeri M, Naderi A, et al. Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial. Acad Emerg Med 2018;25(3):261-6.ObjectivesThe primary outcome of this randomized controlled trial was the percentage of patients whose epistaxis had stopped at 10 minutes from the time of intervention. Secondary outcomes included the frequency of epistaxis recurrence at both 24 hours and 7 days, emergency department length of stay, and patient satisfaction.

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