Was Welling, Ohio (33-Co-2), a Clovis Basecamp or Lithic Workshop? Employing Experimental Models to Interpret Old Collections

2020 ◽  
Vol 86 (1) ◽  
pp. 183-198
Author(s):  
Fernando Diez-Martin ◽  
Briggs Buchanan ◽  
James D. Norris ◽  
Metin I. Eren

Archaeological collections are foundational to the discipline. Yet, researchers who study curated assemblages can face challenges. Here, we show how experimental archaeology can play a vital role in the interpretation of old archaeological collections. The Welling site, in Coshocton County, Ohio, is a multicomponent, stratified site with a substantial Clovis component in its lower levels. Using experimental flaked stone replication, we create an analog model of a “pure” Clovis bifacial debitage assemblage, as might be found at a lithic workshop. We predicted that if the Welling Clovis debitage assemblage was representative of a lithic workshop, then it would be similar to the experimental model. If the debitage assemblage was representative of a base camp, however, then it would be significantly different from the model because Clovis people would have been using, transporting, resharpening, rejuvenating, and recycling the debitage—all activities that would modify a “pure” Clovis bifacial debitage assemblage. Our statistical analyses supported the latter prediction. Overall, our study illustrates how productive the integration of experimental and archaeological data can be, and it emphasizes how important the curation and accessibility of both archaeological and experimental collections are to the discipline.

2010 ◽  
Vol 25 (3) ◽  
pp. 304-310 ◽  
Author(s):  
Cleber Rosito Pinto Kruel ◽  
Luis Felipe Ribeiro Pinto ◽  
Tania Cristina Moita Blanco ◽  
Theresa Christina Barja-Fidalgo ◽  
Levi Lourenzo Melo ◽  
...  

PURPOSE: To study the expression of heme-oxygenase-1 (HO-1), an enzyme induced by oxidative stress, in specimens obtained from an experimental model in rats that evaluated the role of gastric and duodenal reflux in esophageal carcinogenesis. METHODS: Esophageal specimens embedded in paraffin obtained from different experimental groups of rats were used for immunohistochemistry analysis of HO-1 expression. The rats had been divided into the following groups and were killed after 22 weeks: (1) cardioplasty to induce acid reflux; (2) esophagoduodenal anastomosis to induce duodenal reflux; (3) no treatment; (4) cardioplasty + diethylnitrosamine (DEN); (5) esophagoduodenal anastomosis + DEN; and (6) DEN. The study sample comprised 3 specimens from each group with the most severe histopathological lesions found on each study branch. RESULTS: The expression of HO-1 was seen only in rat specimens submitted to esophagoduodenal anastomosis (Groups 2 and 5), and the analysis of mean fluorescence intensity revealed a significant increase of HO-1 expression (4.8 and 4.6 fold, respectively) when compared with the control group (Group 3) (p<0.05). The main target for HO-1 induction was the inflammatory cells inside the tumor or in subepithelial areas. Rats exposed to gastric reflux had no HO-1 expression. CONCLUSION: Reflux esophagitis induced by reflux of duodenal contents, which provoked considerable oxidative stress, may play an important role in esophageal carcinogenesis. Acid reflux did not induce oxidative stress in this experimental model.


2013 ◽  
Vol 284-287 ◽  
pp. 1436-1440 ◽  
Author(s):  
Min Zhang ◽  
Shu Qing Wang ◽  
Jia Li Fu ◽  
Xiao Long Xu

Offshore jacket platforms have been widely used in offshore oil and gas exploitation under hostile ocean environments. Finite element models of such structures need to have many degrees of freedom (DOFs) to represent the geometrical detail of complex structures, which leads to more computing power when performing the analysis and what’s more, the incompatibility in the number of degrees of freedom to the experimental models. Therefore, there is a need to simplify the analytical model by reducing the DOFs and in the process, making the essential eigen-properties agree with those of the experimental model is desired. In this paper, a scaled physical experimental model of an offshore jacket platform is simplified using the recently developed model refinement scheme. Mathematically, the procedure to implement the model refinement technique is an application of cross-model cross-mode (CMCM) method for model updating. The master degrees of freedom are chosen according to the placement of accelerometers in the experiment. Upon the completion of the refinement, the improved reduced jacket platform model matches the dynamic characteristics of the experimental model quite well.


Polar Record ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 193-201
Author(s):  
P.J. Capelotti

ABSTRACTBetween 1898 and 1905, three American expeditions attempted to reach the geographical North Pole from the archipelago of Zemlya Frantsa-Iosifa [Franz Josef Land] and each went to extraordinary and expensive lengths to stage their work. The third of these, the Ziegler polar expedition (1903–1905), led by Anthony Fiala and funded by the American baking soda tycoon William Ziegler, set up numerous camps and caches of supplies along its various expedition routes through the islands. The papers of Anton Vedoe and Ernest Leffingwell at the Rauner Special Collections Library at Dartmouth College reveal both the locations and contents of the caches Fiala ordered to be established in spring 1905, as he made his second and final attempt to reach the pole. These caches extend from the expedition base camp (Camp Abruzzi) at Bukhta Teplitsa [Teplitz Bay] on Ostrov Rudol'fa [Rudolf Island] to the main base of the preceding 1901–1902 Baldwin-Ziegler expedition (Camp Ziegler) on Ostrov Aldzher [Alger Island]. Little is known of the condition of these sites, especially the main cache site of Kane Lodge on Ostrov Grili [Greely Island]. As such, they hold the potential to provide new sources of archaeological data to study American polar ambitions at the turn of the 20th century. While these sites remain unexplored, increasing tourism in the islands necessitates informed planning and field research to establish the nature and stability of these remains so that they may be preserved and the potential effects of tourism mitigated.


2003 ◽  
Vol 18 (spe) ◽  
pp. 60-64 ◽  
Author(s):  
Eliziane Nitz de Carvalho ◽  
Nestor Antônio Schmidt de Carvalho ◽  
Lydia Masako Ferreira

Diabetes mellitus is a potentially morbid condition with high prevalence worldwide, thus being a major medical concern. Experimental models play an important role in understanding such a disease, which is treatable only. This study describes a rat diabetes mellitus model induced by administering a reduced dose of alloxan, thus greatly reducing the animals’ death rate.


2014 ◽  
Vol 71 (6) ◽  
pp. 547-553 ◽  
Author(s):  
Mikica Lalkovic ◽  
Jefta Kozarski ◽  
Ljubomir Panajotovic ◽  
Milan Visnjic ◽  
Dragan Djurdjevic ◽  
...  

Background/Aim. The delay method is a surgical, pharmacological and combined method that includes two or more time separated phases, which gives bigger flap surface. In our research we explored the possibility of flap surface enlargement in a new arterialised venous flap (AVF) on an experimental rabbit ear model by the delay surgical method. The aim of this research was to establish vitality surface of our AVF and to maintain the difference in flap vital surface between AVF flaps, with or without performing the delay surgery method. Methods. We used both ears of ?Big Chinchilla? rabbits in 10 experimental male animals, divided into two groups, average weight 3-3.5 kg, and average age 8-10 months. In the first (experimental) group, a venous flap was arterialised by our method. In the second (control) group, the venous flap was arterialised 14 days after the delay surgical method. AVF surface was measured on the 1 and 14 days by the method of trapezoid rule. Results. Vital surface on our AVF experimental model was bigger than 87% of elevated flap surface after the delay surgical method. Vital surface on AVF without delay on our experimental model was bigger than 30% of elevated flap surface (p < 0.001). Conclusion. Analysis of previous experimental models on the rabbit ear, non-delayed and delayed (to enlarge flap surface) led us to conclusion that previously created experimental models of non-delayed AVF are hemodynamically negative. Our experimental non-delay AVF model is hemodynamically more positive than previously created models of non-delay AVF and provides better conditions for AVF survival and enlargement of vital flap surface of elevated flap. On the other hand, surgical delay method significantly enlarges vital surface of AFF.


2006 ◽  
Vol 4 (3) ◽  
pp. 0-0
Author(s):  
Remigijus Sipavičius ◽  
Aleksejus Zorinas ◽  
Dalia Drobelytė ◽  
Rokas Šerpytis ◽  
Vytautas Sirvydis

Remigijus Sipavičius1, Aleksejus Zorinas1, Dalia Drobelytė2, Rokas Šerpytis2, Vytautas Sirvydis1.1 Vilniaus universiteto Širdies ir kraujagyslių ligų klinikos Širdies chirurgijos centras,Santariškių g. 2, LT-08661 Vilnius2 Vilniaus universiteto Medicinos fakultetas,M. K. Čiurlionio g. 21, LT-03101 VilniusEl. paštas: [email protected] Tikslas Sukurti ar pritaikyti esamus eksperimentinius modelius žiurkėms, tęsiant tyrinėjimus plaučių transplantacijos srityje. Metodai Žiurkėms atliekama kairiojo plaučio autotransplantacija arba ortotopinė transplantacija. Autotransplantacijos atveju atliekama kairiojo plaučio pulmoplegija, plautis paliekamas vietoje konservacijai norimam išemijos laikui. Jam praėjus atkuriama plaučio kraujotaka. Transplantacijos atveju donorui atliekama abiejų plaučių pulmoplegija, jie konservuojami norimą išemijos laiką. Recipientui pašalinamas kairysis plautis. Praėjus išemijos laikui, donoro kairysis plautis persodinamas recipientui, atkuriama plaučio kraujotaka. Rezultatai Atlikta 11 eksperimentų, penki iš jų – sėkmingai. Pagrindinės nesėkmių priežastys buvo broncho ar jo anastomozės plyšimas bei anestetikų perdozavimas. Išvados Esamus eksperimentinius modelius pavyko adaptuoti žiurkėms. Jie taikytini tolesnems plaučių transplantacijos tyrinėjimams. Pagrindiniai žodžiai: plaučių transplantacija, eksperimentinis modelis Left lung transplantation in rat: search for the experimental model Remigijus Sipavičius1, Aleksejus Zorinas1, Dalia Drobelytė2, Rokas Šerpytis2, Vytautas Sirvydis1.1 Vilnius University Clinic of Cardiovascular Diseases, Heart Surgery Centre,Santariškių str. 2, LT-08661 Vilnius, Lithuania2 Vilnius University Faculty of Medicine,M. K. Čiurlionio str. 21, LT-03101 Vilnius, LithuaniaE-mail: [email protected] Objective To design a new or to adapt the existing experimental models of rat lung transplantation. Methods Both left lung autotransplantation and orthotopic transplantation are implemented in rat. At autotransplantation, the left lung is left in situ after pulmoplegia. After a settled ischaemic time the lung perfusion is restored. At transplantation, pulmoplegia is performed in the donor. Lungs are separated and preserved for a settled ischaemic time. The recipient's left lung is removed and the donor's left lung transplantation is performed. The graft's perfusion is restored. Results Eleven experiments were carried out, 5 of them successfully. The main reasons for failure were bronchial anastomosis dehiscence or bronchial tear and anesthetic overdosage. Conclusion Existing experimental models were successfully adapted in rat, capacitating the further lung transplantation research. Key words: lung transplantation, experimental model


2007 ◽  
Vol 1 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Shawn Russett ◽  
Paul Major ◽  
Jason Carey ◽  
Roger Toogood ◽  
Pierre Boulanger

Reproduction of anatomical structures by rapid prototyping has proven to be a valid adjunct for craniofacial surgery, providing alternative methods to produce prostheses and development of surgical guides. The aim of this study was to introduce a methodology to fabricate asymmetric human mandibles by rapid prototyping to be used in future studies for evaluating mandibular symmetries. Stereolithic models of human mandibles were produced with varying amounts of asymmetry in the condylar neck, ramus and body of the mandible by means of rapid prototyping. A method for production of the synthetic mandibles was defined. Model preparation, landmark description and development of the experimental model were described. A series of synthetic mandibles ranging in asymmetry were accurately produced from a scanned human mandible. A method for creating the asymmetries, fabricating, coating and landmarking the synthetic mandibles was formulated. A description for designing a reproducible experimental model for image acquisition was also outlined. Production of synthetic mandibles by stereolithic modeling is a viable method for creating skeletal experimental models with known amounts of asymmetry.


2019 ◽  
Vol 1 (3) ◽  
pp. 18-34 ◽  
Author(s):  
Antonio Leo ◽  
Carmen De Caro ◽  
Valentina Nesci ◽  
Martina Tallarico ◽  
Giovanna Mangano ◽  
...  

The discovery of potential antiseizure drugs (ASDs) requires the use of experimental models that can also provide a unique chance for identifying new effective molecules able to prevent and/or cure epilepsy. Most of the preclinical knowledge on epileptogenesis derives from studies performed on post-insult models that are characterized by a recognizable first insult, a silent period lasting until the onset of the first seizure and a chronic period characterized by spontaneous recurrent seizures (SRSs). At odds, genetic models, in which the first insult remains to be identified, have been poorly investigated. Among the genetic models, the WAG/Rij rat was validated as a suitable experimental model of absence epileptogenesis with neuropsychiatric symptomatology, in which, according to our previous hypothesis on SRSs onset, genes could be considered the first ‘insult’ underlying all plastic modifications supporting the occurrences of absence seizures in this strain. In fact, in several genetic models, the initial insult could be described as the mutation leading to epilepsy that, to date, remains to be defined in this strain. The silent period ends at the occurrence of the first SRS, which is approximately at 2-3 months of age in these rats and after that time the chronic phase initiates, in which, absence seizures increase over time underlying likely further epileptogenic processes. In this review, we describe both the features of this experimental model and the effects of several pharmacological treatments against epileptogenesis and its related comorbidities including depressive-like symptoms and cognitive decline.


2015 ◽  
Vol 308 (1) ◽  
pp. E1-E20 ◽  
Author(s):  
Charlotte J. Green ◽  
Camilla Pramfalk ◽  
Karl J. Morten ◽  
Leanne Hodson

The liver is a main metabolic organ in the human body and carries out a vital role in lipid metabolism. Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, encompassing a spectrum of conditions from simple fatty liver (hepatic steatosis) through to cirrhosis. Although obesity is a known risk factor for hepatic steatosis, it remains unclear what factor(s) is/are responsible for the primary event leading to retention of intrahepatocellular fat. Studying hepatic processes and the etiology and progression of disease in vivo in humans is challenging, not least as NAFLD may take years to develop. We present here a review of experimental models and approaches that have been used to assess liver triglyceride metabolism and discuss their usefulness in helping to understand the aetiology and development of NAFLD.


2009 ◽  
Vol 102 (9) ◽  
pp. 1246-1253 ◽  
Author(s):  
Amaya Aleixandre de Artiñano ◽  
Marta Miguel Castro

Being the metabolic syndrome a multifactorial condition, it is difficult to find adequate experimental models to study this pathology. The obese Zucker rats, which are homozygous for the fa allele, present abnormalities similar to those seen in human metabolic syndrome and are a widely extended model of insulin resistance. The usefulness of these rats as a model of non-insulin-dependent diabetes mellitus is nevertheless questionable, and they neither can be considered a clear experimental model of hypertension. Some experimental models different from the obese Zucker rats have also been used to study the metabolic syndrome. Some derive from the spontaneously hypertensive rats (SHR). In this context, the most important are the obese SHR, usually named Koletsky rats. Hyperinsulinism, associated with either normal or slightly elevated levels of blood glucose, is present in these animals, but SHR/N-corpulent rats are a more appropriated model of non-insulin-dependent diabetes mellitus. The SHR/NDmc corpulent rats, a subline of SHR/N-corpulent rats, also exhibit metabolic and histopathologic characteristics associated with human metabolic disorders. A new animal model of the metabolic syndrome, stroke-prone–SHR (SHRSP) fatty rats, was obtained by introducing a segment of the mutant leptin receptor gene from the Zucker line heterozygous for the fa gene mutation into the genetic background of the SHRSP. Very recently, it has been developed as a non-obese rat model with hypertension, fatty liver and characteristics of the metabolic syndrome by transgenic overexpression of a sterol-regulatory element-binding protein in the SHR rats. The Wistar Ottawa Karlsburg W rats are also a new strain that develops a nearly complete metabolic syndrome. Moreover, a new experimental model of low-capacity runner rats has also been developed with elevated blood pressure levels together with the other hallmarks of the metabolic syndrome.


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