Gravity's Fatal Attraction

2020 ◽  
Author(s):  
Mitchell Begelman ◽  
Martin Rees
Keyword(s):  
Fatal Attraction

scholarly journals Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

2021 ◽  
Vol 22 (5) ◽  
pp. 2240
Author(s):  
Yu Wai Chen ◽  
Shah Kamranur Rahman
Keyword(s):  
Intellectual Disability ◽  
Rna Splicing ◽  
Intrinsically Disordered Proteins ◽  
Cognitive Disorder ◽  
Disordered Proteins ◽  
Thermal Stabilities ◽  
Conformational Disease ◽  
Intrinsically Disordered ◽  
Fatal Attraction ◽  
Experimental Characterisation

The frameshift mutants K192Sfs*7 and R153Sfs*41, of the polyglutamine tract-binding protein 1 (PQBP-1), are stable intrinsically disordered proteins (IDPs). They are each associated with the severe cognitive disorder known as the Renpenning syndrome, a form of X-linked intellectual disability (XLID). Relative to the monomeric wild-type protein, these mutants are dimeric, contain more folded contents, and have higher thermal stabilities. Comparisons can be drawn to the toxic oligomerisation in the “conformational diseases”, which collectively describe medical conditions involving a substantial protein structural transition in the pathogenic mechanism. At the molecular level, the end state of these diseases is often cytotoxic protein aggregation. The conformational disease proteins contain varying extents of intrinsic disorder, and the consensus pathogenesis includes an early oligomer formation. We reviewed the experimental characterisation of the toxic oligomers in representative cases. PQBP-1 mutant dimerisation was then compared to the oligomerisation of the conformational disease proteins. The PQBP-1 mutants are unique in behaving as stable soluble dimers, which do not further develop into higher oligomers or aggregates. The toxicity of the PQBP-1 mutant dimers lies in the native functions (in transcription regulation and possibly, RNA splicing) being compromised, rather than proceeding to aggregation. Other examples of stable IDP dimers were discussed and we speculated on the roles of IDP dimerisation in protein evolution.

Polyglutamine and CBP: Fatal attraction?

10.1038/87842 ◽  
2001 ◽  
Vol 7 (5) ◽  
pp. 528-530 ◽  
Author(s):  
Alexander McCampbell ◽  
Kenneth H. Fischbeck
Keyword(s):  
Fatal Attraction

Fatal attraction: territorial males of a neotropical lizard increase predation risk when females are sexually receptive

2021 ◽  
Vol 75 (12) ◽  
Author(s):  
Stefânia P. R. Ventura ◽  
Conrado A. B. Galdino ◽  
Paulo Enrique C. Peixoto
Keyword(s):  
Predation Risk ◽  
Fatal Attraction

Fatal attraction

2012 ◽  
Vol 12 (11) ◽  
pp. 735-735
Author(s):  
Catriona Rodwell
Keyword(s):  
Fatal Attraction

scholarly journals Lipid droplets and the host–pathogen dynamic: FATal attraction?

2021 ◽  
Vol 220 (8) ◽  
Author(s):  
Marta Bosch ◽  
Matthew J. Sweet ◽  
Robert G. Parton ◽  
Albert Pol
Keyword(s):  
Innate Immunity ◽  
Lipid Droplets ◽  
Innate Immune ◽  
Metabolic Energy ◽  
Eukaryotic Cells ◽  
Bioactive Lipids ◽  
Front Line ◽  
Antimicrobial Proteins ◽  
Current State ◽  
Fatal Attraction

In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in LDs to fuel an expensive lifestyle, innate immunity rewires lipid metabolism and weaponizes LDs to defend cells and animals. Viruses, bacteria, and parasites directly and remotely manipulate LDs to obtain substrates for metabolic energy, replication compartments, assembly platforms, membrane blocks, and tools for host colonization and/or evasion such as anti-inflammatory mediators, lipoviroparticles, and even exosomes. Host LDs counterattack such advances by synthesizing bioactive lipids and toxic nucleotides, organizing immune signaling platforms, and recruiting a plethora of antimicrobial proteins to provide a front-line defense against the invader. Here, we review the current state of this conflict. We will discuss why, when, and how LDs efficiently coordinate and precisely execute a plethora of immune defenses. In the age of antimicrobial resistance and viral pandemics, understanding innate immune strategies developed by eukaryotic cells to fight and defeat dangerous microorganisms may inform future anti-infective strategies.

Fatal Attraction? Popular Modes of Inclusion in the Economic System

2002 ◽  
Vol 8 (1) ◽  
Author(s):  
Urs Stäheli
Keyword(s):  
Stock Market ◽  
Economic System ◽  
Stock Exchange ◽  
Turn Of The Century ◽  
Cultural Identities ◽  
Functional Systems ◽  
Fatal Attraction ◽  
Market Communication ◽  
Crowd Psychology ◽  
Inclusive Society

AbstractThe paper suggests a concept of the popular which understands itself as an alternative to mainstream Cultural Studies which refer to the Popular in terms of hegemonic articulations of socio-cultural identities such as gender, ethnicity, sexuality or class. In contrast, my contention is that the Popular is intrinsically linked to the universalism of functionally differentiated systems. The popular then describes how functional systems use the distinction between a universalistic semantics of inclusion and its seductive, hyper-universalistic exaggeration. At the turn of the century, it was crowd psychology (e.g. Le Bon) which provided the semantics to deal with the new forms of hyper-universalism. The paper uses this redefined notion of the popular for analyzing discourses on speculation and the stock exchange. It focuses on those semantics which implicitly problematize the process of inclusion by trying to make it more attractive. The inclusion of the speculator becomes a process of seduction, resulting in a precarious expansion of inclusion. It is discussed how such a ›massive universalism‹ is produced by stock market communication itself and how it relates to the modern ideal of a more and more inclusive society.

The fatal attraction: A reading of Wilhelm Raabe's Unruhige G�ste

Neophilologus ◽  
1992 ◽  
Vol 76 (3) ◽  
pp. 425-434
Author(s):  
Manfred R. Jacobson
Keyword(s):  
Fatal Attraction

Fatal attraction: explaining variation in the attractiveness of Islamic State propaganda

2018 ◽  
Vol 37 (4) ◽  
pp. 430-450
Author(s):  
Daniel Milton
Keyword(s):  
Islamic State ◽  
Military Operations ◽  
Terrorist Organizations ◽  
Fatal Attraction ◽  
Geographic Expansion

Why do different Islamic State propaganda products receive different numbers of views? This article relies on a dataset of 1700 Islamic State photo essays to examine this question. It finds that violence in Islamic State photo essays, especially retributional violence, or violence directed at the group’s enemies and wayward adherents, leads to increased viewership. Releases that highlight the group’s military operations, governance activities and geographic expansion also draw more attention, although less than the increase for products containing retributional violence. These findings have implications for research and counterterrorism efforts targeted at reducing the propaganda appeal of terrorist organizations.

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