Cow's milk allergy: T cell and IgE recognition of alpha S1-Casein, its CNBr-fragments synthetic peptides

2002 ◽  
Vol 109 (1) ◽  
pp. S178-S178 ◽  
Author(s):  
Said Elsayed ◽  
David J Hill ◽  
Thien Van Do ◽  
Allan Nyfors
Keyword(s):  
T Cell ◽  
Synthetic Peptides ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow’s Milk Allergy

2021 ◽  
pp. 1-12
Author(s):  
Yaqiong Cui ◽  
Yang Yu ◽  
Shuxiang Lin ◽  
Li Xu ◽  
Liuxu Li ◽  
...  
Keyword(s):  
Food Allergy ◽  
T Cell ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
T Cell Epitopes ◽  
Dot Blot ◽  
Allergen Specific Immunotherapy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

<b><i>Background:</i></b> Cow’s milk allergy (CMA) is the most common IgE-mediated food allergy and Bos d 5 is the major allergen in cow’s milk proteins. More than 60% of the patients with CMA are sensitized to this protein. <b><i>Methods and Results:</i></b> A recombinant protein, encoded by a synthetic gene and consisting of reassembled Bos d 5 fragments, was expressed in <i>E. coli</i> strain BL21 (DE3) cells and purified to homogeneity. The B5M lacked relevant IgE-reactivity and allergenic activity compared with Bos d 5 in dot-blot and basophil activation assays. T-cell proliferation experiments demonstrated that B5M preserved the main T cell epitopes of Bos d 5. Immunization of rabbits with B5M induced protective IgG antibodies that blocked the binding of patients’ IgE antibodies to the wild-type allergen and inhibited the degranulation of basophils induced by Bos d 5. <b><i>Conclusion:</i></b> Thus, we developed a new strategy, which was based on rational molecular reassembly for allergen-specific immunotherapy (AIT) of CMA and food allergy.

scholarly journals Cow's milk–specific T-cell reactivity of children with and without persistent cow's milk allergy: Key role for IL-10

2004 ◽  
Vol 113 (5) ◽  
pp. 932-939 ◽  
Author(s):  
Machteld M. Tiemessen ◽  
Adrie G. Van Ieperen-Van Dijk ◽  
Carla A.F.M. Bruijnzeel-Koomen ◽  
Johan Garssen ◽  
Edward F. Knol ◽  
...  
Keyword(s):  
T Cell ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cell Reactivity ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
T Cell Reactivity

scholarly journals α S1 -Casein elucidate major T-cell responses in cow's milk allergy

2017 ◽  
Vol 140 (3) ◽  
pp. 854-857.e6 ◽  
Author(s):  
L. Diego Archila ◽  
Fatima S. Khan ◽  
Nupur Bhatnagar ◽  
David Robinson ◽  
Mary L. Farrington ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cell Responses ◽  
Cow's Milk Allergy

scholarly journals Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab

2012 ◽  
Vol 5 (3) ◽  
pp. 267-276 ◽  
Author(s):  
D Bedoret ◽  
A K Singh ◽  
V Shaw ◽  
E G Hoyte ◽  
R Hamilton ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Number ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
And Function ◽  
Oral Desensitization

scholarly journals Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response

2011 ◽  
Vol 79 (1) ◽  
pp. 192-202 ◽  
Author(s):  
Bertrand Rodriguez ◽  
Guenolée Prioult ◽  
Feriel Hacini-Rachinel ◽  
Deborah Moine ◽  
Anne Bruttin ◽  
...  
Keyword(s):  
T Cell ◽  
Gut Microbiota ◽  
Cell Response ◽  
T Cell Response ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

CD4+ T cell Responses In Cow's Milk allergy

2017 ◽  
Vol 139 (2) ◽  
pp. AB92
Author(s):  
Diego Archila ◽  
Mary L. Farrington ◽  
David M. Robinson ◽  
Fatima S. Khan ◽  
William W. Kwok
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cow’S Milk Allergy ◽  
Cd4 T Cell ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cell Responses ◽  
Cow's Milk Allergy
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