Tu1886 Autophagy and Multidrug Resistance Limit the Efficacy of Salinomycin (Sal) in Gastrointestinal Stromal Tumor (GIST) Cells and Stem Cells (SC) for Interstitial Cells of Cajal (ICC)

2013 ◽  
Vol 144 (5) ◽  
pp. S-872
Author(s):  
Rea A. Nagy ◽  
Emma Watson ◽  
Yujiro Hayashi ◽  
Michael R. Bardsley ◽  
Peter R. Strege ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multidrug Resistance ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Cells Of Cajal

scholarly journals Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769142 ◽  
Author(s):  
Lei Wang ◽  
Jiaqi Hao ◽  
Yijian Zhang ◽  
Ziyi Yang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Extracellular Signal Regulated Kinase ◽  
Stromal Tumors ◽  
Extracellular Signal ◽  
Cells Of Cajal

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca2+ entry mediates the majority of Ca2+ entry in most cancer cells and may be a factor in regulating intracellular Ca2+ in interstitial cells of Cajal and gastrointestinal stromal tumors. Therefore, a blockade of this mechanism may affect the progression of gastrointestinal stromal tumors. Orai1 is the pore subunit of store-operated Ca2+ channels. Here, we reported that Orai1 was overexpressed in gastrointestinal stromal tumor tissues and was positively correlated with a high-risk grade in gastrointestinal stromal tumor patients. Furthermore, upon Orai1 silencing, the functional store-operated Ca2+ entry in gastrointestinal stromal tumor cells was decreased, indicating that the function of store-operated Ca2+ entry was mediated by Orai1. Inhibition of Orai1-mediated store-operated Ca2+ entry by Orai1 silencing or store-operated Ca2+ entry blockers (SKF-96365 and 2-aminoethyl diphenylborate) induced obvious cell proliferation suppression, cell-cycle distribution, and apoptosis stimulation in GIST-T1 cells. Conversely, Orai1 overexpression increased store-operated Ca2+ entry and cell proliferation in GIST882 cells. In addition, we found that activation of c-KIT and the extracellular signal–regulated kinase pathway participated in the oncogenic functions of Orai1-mediated store-operated Ca2+ entry in gastrointestinal stromal tumor cells. These results revealed that Orai1-mediated store-operated Ca2+ entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT and ERK signaling pathway activation. Orai1-mediated store-operated Ca2+ entry plays an oncogenic role and may be a novel prognostic factor and therapeutic target for patients with gastrointestinal stromal tumors.

Congenital Gastrointestinal Pacemaker Cell Tumor

1999 ◽  
Vol 123 (9) ◽  
pp. 842-845 ◽  
Author(s):  
Sandy S. Wu ◽  
Terry L. Buchmiller ◽  
Pamelyn Close ◽  
George B. Gershman ◽  
Shi-Kaung Peng ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cells Of Cajal ◽  
English Language ◽  
Epithelioid Cell ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Pacemaker Cell ◽  
Wall Function ◽  
Pediatric Case ◽  
Cells Of Cajal

Abstract The interstitial cells of Cajal complex within the gut wall function as a pacemaker to direct peristalsis. Their neoplastic counterpart is the gastrointestinal pacemaker cell tumor, a spindle and/or epithelioid cell mesenchymal tumor previously known as gastrointestinal stromal tumor or incorrectly called leiomyosarcoma in some cases of older reports. Although numerous cases of gastrointestinal leiomyosarcomas have been documented in the English-language literature, no pediatric case of gastrointestinal stromal tumor or gastrointestinal pacemaker cell tumor has, to our knowledge, been recorded. Herein, we report a case of congenital gastrointestinal pacemaker cell tumor confirmed by immunohistochemistry and electron microscopy in a full-term male newborn.

scholarly journals Successful Perioperative and Surgical Treatment of a Rare Case of Extra-Gastrointestinal Stromal Tumor Arising in the Prostate Gland

2019 ◽  
Vol 12 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Patrick Schöffski ◽  
Raf Sciot ◽  
Maria Debiec-Rychter ◽  
Johan Van Ongeval ◽  
André D'Hoore ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Prostate Gland ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Smooth Muscle Contractility ◽  
Double Mutation ◽  
Primary Gist ◽  
Common Precursor ◽  
Cells Of Cajal

We report a very uncommon case of a primary, non-metastatic gastrointestinal stromal tumor (GIST) arising in the prostate gland in a 60-year-old patient. The morphology and immunohistochemical profile of the disease resembled GIST of gastrointestinal origin, and the molecular driver of this malignancy was a double mutation in exons 11 and 13 of the KIT gene. The tumor was proliferating slowly, did respond to neoadjuvant therapy with the KIT-inhibiting agent imatinib and was cured by radical, retro-pubic prostatectomy followed by adjuvant imatinib treatment. We postulate that primary GIST tumors of the prostate can arise from prostatic interstitial cells, which are the pacemakers of smooth muscle contractility in the gland, and possibly share a common precursor with typical GIST and the interstitial cells of Cajal in the gastrointestinal tract.

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