scholarly journals 464. Use of Equine Infectious Anaemia Virus (EIAV) To Mediate Indoleamine 2,3-dioxygenase Gene Transfer to Murine Corneal Allograft Transplantation Model Results in Prolongation of Allograft Survival In Vivo with Little Immunogenicity

2006 ◽  
Vol 13 ◽  
pp. S179-S180
Author(s):  
Peng H. Tan ◽  
Sven C. Beutelspacher ◽  
Andrew J.T. George
Keyword(s):  
Gene Transfer ◽  
Allograft Survival ◽  
Corneal Allograft ◽  
Allograft Transplantation ◽  
Indoleamine 2,3 Dioxygenase ◽  
Dioxygenase Gene ◽  
Equine Infectious Anaemia Virus ◽  
Transplantation Model

Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival

2006 ◽  
Vol 8 (4) ◽  
pp. 459-467 ◽  
Author(s):  
Nianqiao Gong ◽  
Uwe Pleyer ◽  
Jun Yang ◽  
Katrin Vogt ◽  
Marcelo Hill ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Allograft Survival ◽  
Corneal Allograft

The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival

2007 ◽  
Vol 245 (10) ◽  
pp. 1515-1521 ◽  
Author(s):  
Daniel Fabian ◽  
Nianqiao Gong ◽  
Katrin Vogt ◽  
Hans-Dieter Volk ◽  
Uwe Pleyer ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Fusion Protein ◽  
Allograft Survival ◽  
Corneal Allograft ◽  
Inducible Costimulator

scholarly journals Effects of local and systemic viral interleukin-10 gene transfer on corneal allograft survival

Gene Therapy ◽  
2006 ◽  
Vol 14 (6) ◽  
pp. 484-490 ◽  
Author(s):  
N Gong ◽  
U Pleyer ◽  
H-D Volk ◽  
T Ritter
Keyword(s):  
Gene Transfer ◽  
Interleukin 10 ◽  
Allograft Survival ◽  
Corneal Allograft

J2 prolongs the corneal allograft survival through inhibition of the CD4+ T cell-mediated response in vivo

2007 ◽  
Vol 18 (2) ◽  
pp. 130-137 ◽  
Author(s):  
He Xiao ◽  
Han Zhang ◽  
Zu-Yin Yu ◽  
Lei Zhang ◽  
Ming Yu ◽  
...  
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Allograft Survival ◽  
Corneal Allograft

scholarly journals Nfe2l1-silenced insulinoma cells acquire aggressiveness and chemoresistance

2018 ◽  
Vol 25 (3) ◽  
pp. 185-200 ◽  
Author(s):  
Jingqi Fu ◽  
Hongzhi Zheng ◽  
Qi Cui ◽  
Chengjie Chen ◽  
Simeng Bao ◽  
...  
Keyword(s):  
Antioxidant Response ◽  
Endocrine Tumors ◽  
Mitochondrial Potential ◽  
Allograft Transplantation ◽  
Pancreatic Endocrine Tumors ◽  
Altered Glucose ◽  
Insulinoma Cells ◽  
Transplantation Model

The transcription factor nuclear factor erythroid 2-like 1 (NFE2L1 or NRF1) is involved in various critical cell processes such as maintenance of ubiquitin-proteasome system and regulation of the cellular antioxidant response. We previously determined that pancreatic β-cell-specific Nfe2l1-knockout mice had hyperinsulinemia and that silencing of Nfe2l1 in mouse islets or MIN6 insulinoma β-cells induced elevated basal insulin release and altered glucose metabolism. Hypoglycemia is a major issue with aggressive insulinomas, although a role of NFE2L1 in this pathology is not defined. In the present work, we studied the tumorigenicity of Nfe2l1-deficient insulinoma MIN6 cells (Nfe2l1-KD) and sensitivity to chemotherapy. Nfe2l1-KD cells grew faster and were more aggressive than Scramble cells in vitro. In a mouse allograft transplantation model, insulinomas arising from Nfe2l1-KD cells were more aggressive and chemoresistant. The conclusion was amplified using streptozotocin (STZ) administration in an allograft transplantation model in diabetic Akita background mice. Furthermore, Nfe2l1-KD cells were resistant to damage by the chemotherapeutic drugs STZ and 5-fluorouracil, which was linked to binding of hexokinase 1 with mitochondria, enhanced mitochondrial membrane potential and closed mitochondrial potential transition pore. Overall, both in vitro and in vivo data from Nfe2l1-KD insulinoma cells provided evidence of a previously un-appreciated action of NFE2L1 in suppression of tumorigenesis. Nfe2l1 silencing desensitizes insulinoma cells and derived tumors to chemotherapeutic-induced damage, likely via metabolic reprograming. These data indicate that NFE2L1 could potentially play an important role in the carcinogenic process and impact chemosensitivity, at least within a subset of pancreatic endocrine tumors.

The Potential of Viral Vector-Mediated Gene Transfer to Prolong Corneal Allograft Survival

2009 ◽  
Vol 9 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Douglas Parker ◽  
Helen Brereton ◽  
Douglas Coster ◽  
Keryn Williams
Keyword(s):  
Gene Transfer ◽  
Viral Vector ◽  
Allograft Survival ◽  
Corneal Allograft

Effects of interleukin-12p40 gene transfer on rat corneal allograft survival

2007 ◽  
Vol 18 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Thomas Ritter ◽  
Jun Yang ◽  
Haike Dannowski ◽  
Katrin Vogt ◽  
Hans-Dieter Volk ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Allograft Survival ◽  
Corneal Allograft

In vivo gene transfer of cationic lipid-protamine-DNA complexes to enhance cardiac allograft survival

1998 ◽  
Vol 4 (3) ◽  
pp. 24
Author(s):  
Warren D. Rosenblum ◽  
Won Lee ◽  
Bo Sun ◽  
Carol Weis ◽  
Shiguang Qian ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Lipid ◽  
Cardiac Allograft ◽  
Allograft Survival ◽  
Dna Complexes ◽  
In Vivo Gene Transfer
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