scholarly journals 257. VEGF Gene Transfered Bone Marrow Stromal Cells by Replication-Deficiet Herpes Simplex Virus Type-1 (HSV-1) Vector Can Improve the Neurological Deficits and Reduce the Infaction in Rat Ischemic Brain

2006 ◽  
Vol 13 ◽  
pp. S99
Author(s):  
Yoshihito Miki ◽  
Naosuke Nonoguchi ◽  
Naokado Ikeda ◽  
Ming-Zhu Zhao ◽  
Daisuke Furutama ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Herpes Simplex ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Neurological Deficits ◽  
Vegf Gene ◽  
Ischemic Brain ◽  
Simplex Virus

Combination therapy with bone marrow stromal cells and FK506 enhanced amelioration of ischemic brain damage in rats

Life Sciences ◽  
2011 ◽  
Vol 89 (1-2) ◽  
pp. 50-56 ◽  
Author(s):  
Satoshi Suda ◽  
Kuniko Shimazaki ◽  
Masayuki Ueda ◽  
Toshiki Inaba ◽  
Nobuo Kamiya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Combination Therapy ◽  
Brain Damage ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Ischemic Brain Damage ◽  
Ischemic Brain

Bone Marrow Stromal Cells Rescue Ischemic Brain by Trophic Effects and Phenotypic Change Toward Neural Cells

2014 ◽  
Vol 29 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Hideo Shichinohe ◽  
Takeshi Ishihara ◽  
Koji Takahashi ◽  
Yoshikazu Tanaka ◽  
Michiyuki Miyamoto ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Phenotypic Change ◽  
Neural Cells ◽  
Ischemic Brain ◽  
Trophic Effects

scholarly journals OP0096 DYSREGULATED BONE MARROW STROMAL CELLS IN MODIC TYPE 1 CHANGES

2019 ◽  
Author(s):  
Stefan Dudli ◽  
Dominik Haenni ◽  
Astrid Juengel ◽  
Michael Betz ◽  
Jose Spirig ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Modic Type

scholarly journals Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes

2021 ◽  
Vol 41 ◽  
pp. 648-667
Author(s):  
I Heggli ◽  
◽  
S Epprecht ◽  
A Juengel ◽  
R Schuepbach ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Collagen Type ◽  
Collagen Type I ◽  
Marrow Stromal Cells ◽  
Type I ◽  
Cell Contractility ◽  
Modic Type

Modic type 1 changes (MC1) are painful vertebral bone marrow lesions frequently found in patients suffering from chronic low-back pain. Marrow fibrosis is a hallmark of MC1. Bone marrow stromal cells (BMSCs) are key players in other fibrotic bone marrow pathologies, yet their role in MC1 is unknown. The present study aimed to characterise MC1 BMSCs and hypothesised a pro-fibrotic role of BMSCs in MC1. BMSCs were isolated from patients undergoing lumbar spinal fusion from MC1 and adjacent control vertebrae. Frequency of colony-forming unit fibroblast (CFU-F), expression of stem cell surface markers, differentiation capacity, transcriptome, matrix adhesion, cell contractility as well as expression of pro-collagen type I alpha 1, α-smooth muscle actin, integrins and focal adhesion kinase (FAK) were compared. More CFU-F and increased expression of C-X-C-motif-chemokine 12 were found in MC1 BMSCs, possibly indicating overrepresentation of a perisinusoidal BMSC population. RNA sequencing analysis showed enrichment in extracellular matrix proteins and fibrosis-related signalling genes. Increases in pro-collagen type I alpha 1 expression, cell adhesion, cell contractility and phosphorylation of FAK provided further evidence for their pro-fibrotic phenotype. Moreover, a leptin receptor high expressing (LEPRhigh) BMSC population was identified that differentiated under transforming growth factor beta 1 stimulation into myofibroblasts in MC1 but not in control BMSCs. In conclusion, pro-fibrotic changes in MC1 BMSCs and a LEPRhigh MC1 BMSC subpopulation susceptible to myofibroblast differentiation were found. Fibrosis is a hallmark of MC1 and a potential therapeutic target. A causal link between the pro-fibrotic phenotype and clinical characteristics needs to be demonstrated.

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