scholarly journals 877. Evidence for Dominant-Negative Interference in the Pahenu2 Mouse Model of PKU

2004 ◽  
Vol 9 ◽  
pp. S334
Keyword(s):  
Mouse Model ◽  
Dominant Negative ◽  
Negative Interference ◽  
Dominant Negative Interference

scholarly journals Dominant‐negative interference with defence signalling by truncation mutations of the tomato Cf‐9 disease resistance gene

2006 ◽  
Vol 46 (3) ◽  
pp. 385-399 ◽  
Author(s):  
Claire L. Barker ◽  
Brett K. Baillie ◽  
Kim E. Hammond‐Kosack ◽  
Jonathan D. G. Jones ◽  
David A. Jones
Keyword(s):  
Disease Resistance ◽  
Resistance Gene ◽  
Dominant Negative ◽  
Disease Resistance Gene ◽  
Negative Interference ◽  
Defence Signalling ◽  
Dominant Negative Interference

scholarly journals 214. Dominant-Negative Interference in the Pahenu2 Mouse: Modified Forms of PAH

2006 ◽  
Vol 13 ◽  
pp. S82-S83
Author(s):  
Andreas Zori ◽  
Dawn D. Yang ◽  
Jon-Michael Knapp ◽  
Catherine E. Charron ◽  
Jennifer E. Embury ◽  
...  
Keyword(s):  
Dominant Negative ◽  
Negative Interference ◽  
Dominant Negative Interference ◽  
Modified Forms

scholarly journals Transforming Growth Factor β/Smad3 Signaling Regulates IRF-7 Function and Transcriptional Activation of the Beta Interferon Promoter

2004 ◽  
Vol 24 (3) ◽  
pp. 1411-1425 ◽  
Author(s):  
Jing Qing ◽  
Cheng Liu ◽  
Lisa Choy ◽  
Rui-Yun Wu ◽  
Joseph S. Pagano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transcriptional Activation ◽  
Transforming Growth Factor ◽  
Critical Role ◽  
Transforming Growth Factor Β ◽  
Dominant Negative ◽  
Negative Interference ◽  
Rapid Induction ◽  
Dominant Negative Interference ◽  
Smad3 Expression

ABSTRACT The rapid induction of alpha interferon (IFN-α) and IFN-β expression plays a critical role in the innate immune response against viral infection. We studied the effects of transforming growth factor β (TGF-β) and its intracellular effectors, the Smads, on the function of IRF-7, an essential transcription factor for IFN-α and -β induction. IRF-7 interacted with Smads, and IRF-7, but not IRF-3, cooperated with Smad3 to activate IFN-β transcription. This transcriptional cooperation occurred at the IRF-binding sequences in the IFN-β promoter, and dominant-negative interference with TGF-β receptor signaling and Smad3 function decreased IRF-7-mediated transcription. Furthermore, elimination of Smad3 expression in Smad3−/− fibroblasts delayed and decreased double-stranded RNA-induced expression of endogenous IFN-β, whereas restoration of Smad3 expression enhanced IFN-β induction. The IRF-7-Smad3 cooperativity resulted from the regulation of the transactivation activity of IRF-7 by Smad3, and dominant-negative interference with Smad3 function decreased IRF-7 activity. Consistent with the regulation by Smad3, the transcriptional activity of IRF-7 depended on and was regulated by TGF-β signaling. Our studies underscore a role of TGF-β/Smad3 signaling in IRF-7-mediated induction of IFN-β expression.

Dominant Negative TNF Inhibitor in a Mouse Model of Depression

2013 ◽  
Author(s):  
Christopher J. Barnum ◽  
Malu G. Tansey ◽  
Andrew H. Miller
Keyword(s):  
Mouse Model ◽  
Dominant Negative ◽  
Tnf Inhibitor

scholarly journals Cellular Werner Phenotypes in Mice Expressing a Putative Dominant-Negative Human WRN Gene

Genetics ◽  
2000 ◽  
Vol 154 (1) ◽  
pp. 357-362
Author(s):  
Lan Wang ◽  
Charles E Ogburn ◽  
Carol B Ware ◽  
Warren C Ladiges ◽  
Hagop Youssoufian ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mice ◽  
Werner Syndrome ◽  
Dominant Negative ◽  
Dominant Negative Mutation ◽  
Fibroblast Cultures ◽  
Age Related

Abstract Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice expressing human WRN with a putative dominant-negative mutation (K577M-WRN). Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to 4-nitroquinoline-1-oxide (4NQO), reduced replicative potential, and reduced expression of the endogenous WRN protein. These data suggest that K577M-WRN mice may provide a novel mouse model for the WS.

Intracerebroventricular delivery of dominant negative prion protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura graft transplantation

2006 ◽  
Vol 402 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Kazuhide Furuya ◽  
Nobutaka Kawahara ◽  
Yoshio Yamakawa ◽  
Hitaru Kishida ◽  
Naomi S. Hachiya ◽  
...  
Keyword(s):  
Mouse Model ◽  
Prion Protein ◽  
Dominant Negative ◽  
Jakob Disease
Sign in / Sign up

Export Citation Format

Share Document