Animal models of type I allergy using recombinant allergens

Methods ◽  
2004 ◽  
Vol 32 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Udo Herz ◽  
Harald Renz ◽  
Ursula Wiedermann
Keyword(s):  
Animal Models ◽  
Recombinant Allergens ◽  
Type I ◽  
Type I Allergy

Allergy testing: the role of recombinant allergens

2006 ◽  
Vol 44 (2) ◽  
Author(s):  
Nadine Mothes ◽  
Rudolf Valenta ◽  
Susanne Spitzauer
Keyword(s):  
Specific Immunotherapy ◽  
Simultaneous Detection ◽  
In Vitro Tests ◽  
Recombinant Allergen ◽  
Recombinant Allergens ◽  
Type I ◽  
Type I Allergy ◽  
Specific Igg ◽  
Allergen Extracts

AbstractCurrently, diagnosis of type I allergy is performed using crude allergen extracts, which allow the identification of the allergen-containing source responsible for type I allergic symptoms (e.g., allergic rhino-conjunctivitis, asthma) but not the disease-eliciting molecules. With the introduction of recombinant allergens produced by molecular biology techniques, a large panel of allergenic molecules has become available. The application of these recombinant allergens for in vitro tests has led to new forms of component-resolved diagnosis (CRD) and allows the establishment of a patient's individual reactivity profile. The increasing number of recombinant allergens characterized during the last decade has allowed the development of chip-based allergy tests for simultaneous detection of up to 5000 different allergens and epitopes. The introduction of these recombinant allergen-based tests into clinical practice improves the selection of patients for traditional specific immunotherapy and allows monitoring of the immunological efficacy of specific immunotherapy by measuring allergen-specific IgG antibodies. Besides their diagnostic application, recombinant allergens and hypoallergenic derivatives thereof have also been used as vaccines in clinical trials, and recent results have shown their usefulness for the treatment of type I allergy.

Formalin-Fixed Staphylococcus aureus Particles Prevent Allergic Sensitization in a Murine Model of Type I Allergy

2007 ◽  
Vol 144 (3) ◽  
pp. 183-196 ◽  
Author(s):  
Karina Gisch ◽  
Nadine Gehrke ◽  
Matthias Bros ◽  
Christina Priesmeyer ◽  
Jürgen Knop ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Murine Model ◽  
Allergic Sensitization ◽  
Type I ◽  
Type I Allergy ◽  
Formalin Fixed

scholarly journals Impedance-Based Living Cell Analysis for Clinical Diagnosis of Type I Allergy

Sensors ◽  
2017 ◽  
Vol 17 (11) ◽  
pp. 2503 ◽  
Author(s):  
Reiko Irifuku ◽  
Yuhki Yanase ◽  
Tomoko Kawaguchi ◽  
Kaori Ishii ◽  
Shunsuke Takahagi ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Living Cell ◽  
Type I ◽  
Cell Analysis ◽  
Type I Allergy

scholarly journals Clinical diagnosis of type I allergy by means of SPR imaging with less than a microliter of peripheral blood

2014 ◽  
Vol 2 ◽  
pp. 43-48 ◽  
Author(s):  
Yuhki Yanase ◽  
Takaaki Hiragun ◽  
Tetsuji Yanase ◽  
Tomoko Kawaguchi ◽  
Kaori Ishii ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Peripheral Blood ◽  
Type I ◽  
Type I Allergy ◽  
Spr Imaging

Type I Allergy to Egg and Milk Proteins: Comparison of Skin Prick Tests with Nasal, Buccal and Gastric Provocation Tests

1985 ◽  
Vol 77 (1-2) ◽  
pp. 171-173 ◽  
Author(s):  
P.L. Amlot ◽  
R. Urbanek ◽  
L.J.F. Youlten ◽  
M. Kemeny ◽  
M.H. Lessof
Keyword(s):  
Milk Proteins ◽  
Type I ◽  
Type I Allergy ◽  
Provocation Tests ◽  
Skin Prick Tests

mRNA vaccination as a safe approach for specific protection from type I allergy

2012 ◽  
Vol 11 (1) ◽  
pp. 55-67 ◽  
Author(s):  
Richard Weiss ◽  
Sandra Scheiblhofer ◽  
Elisabeth Roesler ◽  
Esther Weinberger ◽  
Josef Thalhamer
Keyword(s):  
Type I ◽  
Type I Allergy ◽  
Safe Approach
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