Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndromes

2006 ◽  
Vol 41 (6) ◽  
pp. 1044-1044
Author(s):  
M MYOISHI ◽  
H HAO ◽  
M KITAKAZE
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Acute Coronary Syndromes ◽  
Atherosclerotic Plaques ◽  
Coronary Syndromes

Heat Production of Atherosclerotic Plaques and Inflammation Assessed by the Acute Phase Proteins in Acute Coronary Syndromes

2000 ◽  
Vol 32 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Christodoulos Stefanadis ◽  
Leonidas Diamantopoulos ◽  
John Dernellis ◽  
Emanuel Economou ◽  
Eleftherios Tsiamis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Heat Production ◽  
Acute Coronary Syndromes ◽  
Acute Phase Proteins ◽  
Atherosclerotic Plaques ◽  
Coronary Syndromes

scholarly journals Oxygen-regulated protein 150 and prognosis following myocardial infarction

2007 ◽  
Vol 112 (9) ◽  
pp. 477-484 ◽  
Author(s):  
Leong L. Ng ◽  
Russell J. O'Brien ◽  
Paulene A. Quinn ◽  
Iain B. Squire ◽  
Joan E. Davies
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Endoplasmic Reticulum ◽  
Odds Ratio ◽  
Acute Coronary Syndromes ◽  
Cox Regression ◽  
Cardiovascular Morbidity ◽  
Prognostic Information ◽  
Coronary Syndromes

ORP150 (oxygen-regulated protein 150) is a chaperonin expressed in tissues undergoing hypoxic or endoplasmic reticulum stress. In the present study, we investigated plasma levels of ORP150 in patients with AMI (acute myocardial infarction) and its relationship with prognosis, together with a known risk marker N-BNP (N-terminal pro-B-type natriuretic peptide). Plasma from 396 consecutive patients with AMI was obtained for measurement of ORP150 and N-BNP. Mortality and cardiovascular morbidity (acute coronary syndromes/heart failure) was determined during follow-up. A specific ORP150 assay detected the 150 kDa protein in plasma extracts, including 3 and 7 kDa fragments. During follow-up (median, 455 days), 43 (10.9%) patients died. Both N-BNP and ORP150 levels were higher in those who died compared with the survivors [N-BNP, 724 (14.5–28840) compared with 6167 (154.9–33884) pmol/l (P<0.0005); ORP150, 257 (5.9–870.9) compared with 331 (93.3–831.8) pmol/l (P<0.001); values are medians (range)]. In a Cox regression model for mortality prediction, both N-BNP (odds ratio, 5.06; P<0.001) and ORP150 (odds ratio, 2.39; P<0.01) added prognostic information beyond creatinine and the use of thrombolytics. A Kaplan–Meier survival analysis revealed that ORP150 added prognostic information to N-BNP, especially in those with supra-median N-BNP levels. A simplified dual-marker approach with both markers below and either above or both above their respective medians effectively stratified mortality risk (log rank statistic for trend, 32.7; P<0.00005). ORP150 levels were not predictive of other cardiovascular morbidity (acute coronary syndromes or heart failure). In conclusion, ORP150 and peptide fragments derived from it are secreted following AMI and provide independent prognostic information on mortality. High levels associated with endoplasmic reticulum/hypoxic stress predict a poor outcome.

scholarly journals Different Quantitative Apoptotic Traits in Coronary Atherosclerotic Plaques From Patients With Stable Angina Pectoris and Acute Coronary Syndromes

Circulation ◽  
2004 ◽  
Vol 110 (13) ◽  
pp. 1767-1773 ◽  
Author(s):  
Marco L. Rossi ◽  
Nicola Marziliano ◽  
Piera Angelica Merlini ◽  
Ezio Bramucci ◽  
Umberto Canosi ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Acute Coronary Syndromes ◽  
Atherosclerotic Plaques ◽  
Stable Angina Pectoris ◽  
Coronary Syndromes

scholarly journals Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome

Circulation ◽  
2007 ◽  
Vol 116 (11) ◽  
pp. 1214-1216 ◽  
Author(s):  
Jeffrey G. Dickhout ◽  
Stephen M. Colgan ◽  
Šárka Lhoták ◽  
Richard C. Austin
Keyword(s):  
Endoplasmic Reticulum ◽  
Acute Coronary Syndrome ◽  
Endoplasmic Reticulum Stress ◽  
Atherosclerotic Plaques ◽  
Coronary Syndrome

scholarly journals Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes

2002 ◽  
Vol 40 (11) ◽  
pp. 1919-1927 ◽  
Author(s):  
Joerg Herrmann ◽  
William D Edwards ◽  
David R Holmes ◽  
Kris L Shogren ◽  
Lilach O Lerman ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Atherosclerotic Plaques ◽  
Coronary Syndromes

Temperature Measurement of Advanced Murine Atherosclerotic Plaques

2007 ◽  
Author(s):  
Frank Gijsen ◽  
Anna Ten Have ◽  
Jolanda Wentzel ◽  
Antonius Van Der Steen
Keyword(s):  
Heart Disease ◽  
Vulnerable Plaque ◽  
Acute Coronary Syndromes ◽  
Coronary Atherosclerosis ◽  
Developmental Stages ◽  
Atherosclerotic Plaques ◽  
Fibrous Cap ◽  
Vulnerable Plaques ◽  
Coronary Syndromes ◽  
Plaque Detection

Ischaemic heart disease is most frequently caused by coronary atherosclerosis, of which the vulnerable plaque is one of the developmental stages. Rupture of a vulnerable plaque with superimposed thrombosis frequently leads to acute coronary syndromes. The major components of a vulnerable plaque are a lipid-rich, atheromatous core, and a thin fibrous cap with macrophage and macrophage infiltration (Schaar et al., 2004). After the first paper suggesting the possibility of thermographic detection of vulnerable plaques (Casscells et al., 1996), intracoronary thermography as a vulnerable plaque detection technique has been investigated. Increased metabolic activity of macrophages is suggested as the main reasons for the increased temperatures (ten Have et al., 2005).

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