The effect of left and right long-term amygdala kindling on interictal emotionality and Fos expression

2020 ◽  
Vol 104 ◽  
pp. 106910
Author(s):  
Neil M. Fournier ◽  
Lianne E. Brandt ◽  
Lisa E. Kalynchuk
2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 4-5
Author(s):  
Martyna E Lagoda ◽  
Laura A Boyle ◽  
Joanna Marchewka ◽  
Julia A Calderón Díaz

Abstract Aggressive behavior resulting from mixing to establish a dominance hierarchy is a welfare concern for group-housed sows. The associated stress could negatively impact reproductive performance (RP). Objectives of this study were to investigate associations between 1) mixing aggression intensity and RP within and between parities one (P1) and two (P2), and 2) aggression intensity, floor type and RP. A total of 164 gilts were followed through two parities. Gilts were mixed into stable groups of eight unfamiliar individuals four days after insemination, and housed on fully-slatted floors, either uncovered (CON; n = 84) or covered (RUB; n = 80) by a rubber slat-mat until farrowing (for both parities). Skin lesion scores (SLS) (proxy for mixing aggression intensity), were recorded 24–72 hrs post-mixing (0 = no lesions to 5 = severe lesions) on five body regions on left and right sides, and on the tail, in both parities. Total SLS was calculated for each sow. RP data were retrospectively acquired from farm records for both parities. Data were analyzed using GLMM in PROC GLIMMIX of SAS (v9.4) where 1) each parity analyzed separately, and 2) SLS in P1 used to predict RP in P2. Gilts with higher SLS in P2 had higher piglet mortality (P = 0.021) and longer cycle length (P = 0.003) in P2. Gilts with higher SLS in P1 had more non-productive days (P < 0.001) in P2. CON gilts had higher SLS than RUB gilts (P = 0.017) in P1, but not in P2 (P > 0.05). CON gilts also had more piglets born dead (P = 0.004) and tended to crush more piglets (P = 0.097) in P2. Our results confirm that mixing aggression impacts RP in the current parity negatively. They also suggest that mixing aggression experienced by gilts may have long-term negative carry-over effects on performance in subsequent parities. Use of rubber flooring appears to mitigate detrimental effects of mixing aggression, perhaps through improved sow comfort.


1997 ◽  
Vol 272 (3) ◽  
pp. H1196-H1204 ◽  
Author(s):  
V. A. Browne ◽  
V. M. Stiffel ◽  
W. J. Pearce ◽  
L. D. Longo ◽  
R. D. Gilbert

We studied myocardial contractility in fetal sheep from ewes exposed to approximately 112 days of hypoxia at high altitude (3,820 m). We measured the inotropic response to extracellular Ca2+ concentration ([Ca2+]o, 0.2-10 mM) and ryanodine (10(-10) to 10(-4) M) in isometrically contracting papillary muscles and quantified dihydropyridine (DHPR) and ryanodine (RyR) receptors. In hypoxic fetuses, curves describing the force-[Ca2+]o relationship were shifted left, and the top plateaus were decreased by approximately 35% in both left and right ventricles. In normoxic and hypoxic fetuses, ryanodine (10(-4) M) reduced maximum active tension (Tmax) to approximately 25-40% of baseline values, indicating that the sarcoplasmic reticulum was the chief source of activator Ca2+ and that Ca2+ influx alone was not sufficient to activate a contraction of normal amplitude. Hypoxia resulted in a lower Tmax in the right ventricle and a lower maximum rate of rise in the left ventricle after treatment with ryanodine. DHPR number did not change, but RyR number and the RyR/DHPR in both ventricles were higher in hypoxic fetuses. We conclude that hypoxia decreases contractility, possibly by reducing the availability of activator Ca2+. Further studies are needed to directly measure the Ca2+ current and intracellular Ca2+ transient and to examine myofilament protein and adenosinetriphosphatase activity.


1997 ◽  
Vol 41 (4) ◽  
pp. 438-451 ◽  
Author(s):  
Lisa E. Kalynchuk ◽  
John P.J. Pinel ◽  
Dallas Treit ◽  
Tod E. Kippin

2016 ◽  
Vol 313 ◽  
pp. 260-271 ◽  
Author(s):  
Thomaz Lüscher Dias ◽  
Hudson Fernandes Golino ◽  
Vinícius Elias Moura de Oliveira ◽  
Márcio Flávio Dutra Moraes ◽  
Grace Schenatto Pereira

Pain ◽  
1999 ◽  
Vol 80 (1) ◽  
pp. 347-357 ◽  
Author(s):  
Gwénaëlle Catheline ◽  
Stéphanie Le Guen ◽  
Prisca Honoré ◽  
Jean-Marie Besson

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