scholarly journals The long-term course of temporal lobe epilepsy: From unilateral to bilateral interictal epileptiform discharges in repeated video-EEG monitorings

2017 ◽  
Vol 68 ◽  
pp. 17-21 ◽  
Author(s):  
Stephanie Gollwitzer ◽  
Catherine A. Scott ◽  
Fiona Farrell ◽  
Gail S. Bell ◽  
Jane de Tisi ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges ◽  
Video Eeg

scholarly journals The first-hour-of-the-day sleep EEG reliably identifies interictal epileptiform discharges during long-term video-EEG monitoring

Seizure ◽  
2018 ◽  
Vol 63 ◽  
pp. 48-51 ◽  
Author(s):  
Xi Liu ◽  
Naoum P. Issa ◽  
Sandra Rose ◽  
Shasha Wu ◽  
Taixin Sun ◽  
...  
Keyword(s):  
Sleep Eeg ◽  
Eeg Monitoring ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges ◽  
Video Eeg

scholarly journals Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy

2016 ◽  
Vol 22 (6) ◽  
pp. 641-648 ◽  
Author(s):  
Jennifer N Gelinas ◽  
Dion Khodagholy ◽  
Thomas Thesen ◽  
Orrin Devinsky ◽  
György Buzsáki
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges

Unilateral temporal interictal epileptiform discharges correctly predict the epileptogenic zone in lesional temporal lobe epilepsy

Epilepsia ◽  
2018 ◽  
Vol 59 (8) ◽  
pp. 1577-1582 ◽  
Author(s):  
Christian Vollmar ◽  
Iris Stredl ◽  
Matthias Heinig ◽  
Soheyl Noachtar ◽  
Jan Rémi
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epileptogenic Zone ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges

scholarly journals Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
F. T. Sparks ◽  
Z. Liao ◽  
W. Li ◽  
A. Grosmark ◽  
I. Soltesz ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cells ◽  
Topic Model ◽  
Network Activity ◽  
Relative Contribution ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges ◽  
Cell Type Specific ◽  
Specific Contribution

AbstractTemporal lobe epilepsy (TLE) is characterized by recurrent seizures driven by synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing from this pathophysiological intuition. In particular, the relative contribution of adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unknown. We assess dynamics of abGCs and mGCs during interictal epileptiform discharges (IEDs) in mice with TLE as well as sharp-wave ripples (SPW-Rs) in healthy mice, and find that abGCs and mGCs are desynchronized and differentially recruited by IEDs compared to SPW-Rs. We introduce a neural topic model to explain these observations, and find that epileptic DG networks organize into disjoint, cell-type specific pathological ensembles in which abGCs play an outsized role. Our results characterize identified GC subpopulation dynamics in TLE, and reveal a specific contribution of abGCs to IEDs.

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