Cost-utility analysis of competing treatment strategies for drug-resistant epilepsy in children with Tuberous Sclerosis Complex

2016 ◽  
Vol 63 ◽  
pp. 79-88 ◽  
Author(s):  
Aria Fallah ◽  
Alexander G. Weil ◽  
Shelly Wang ◽  
Evan Lewis ◽  
Christine B. Baca ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Treatment Strategies ◽  
Cost Utility ◽  
Cost Utility Analysis ◽  
Drug Resistant ◽  
Utility Analysis ◽  
Drug Resistant Epilepsy

TSC1 and TSC2: Tuberous Sclerosis Complex and Its Related Epilepsy Phenotype

2021 ◽  
Author(s):  
Claudia Di Napoli ◽  
Alessia Gennaro ◽  
Carmelania Lupica ◽  
Raffaele Falsaperla ◽  
Roberta Leonardi ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Mtor Inhibitor ◽  
Autosomal Dominant ◽  
Treatment Strategies ◽  
Neurological Impairment ◽  
Drug Resistant ◽  
Autosomal Dominant Disorder ◽  
Mechanistic Target Of Rapamycin ◽  
Neuropsychiatric Manifestations

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by a multisystemic involvement. In TSC, reduced function of TSC1 and TSC2 genes products (hamartin and tuberin, respectively) leads to an hyperactivation of the mechanistic target of rapamycin (mTOR) pathway and to a consequent cell growth dysregulation. In TSC patients, neurological and neuropsychiatric manifestations, especially epilepsy and neuropsychiatric comorbidities such as autism or intellectual disability, represent the most disabling features. In particular, epilepsy occurrs up to 80% of patients, is often drug resistant and is frequently associated with neurological impairment. Due to the burden of this morbidity, different treatment strategies have been proposed with the purpose to make patients epilepsy free, such as the use of different antiepileptic drugs like vigabatrin, carbamazepine, valproic acid, and levetiracetam. More recently, a mTOR inhibitor (i.e. everolimus) has showed promising results in terms of seizures reduction.

Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex

2022 ◽  
Vol 126 ◽  
pp. 108431
Author(s):  
Xuezhi Tong ◽  
Xiongfei Wang ◽  
Lang Qin ◽  
Jian Zhou ◽  
Yuguang Guan ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy
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