Drug-resistant focal epilepsy in women of childbearing age: Reproduction and the effect of epilepsy surgery

2016 ◽  
Vol 60 ◽  
pp. 17-20 ◽  
Author(s):  
Rachel R. Fabris ◽  
Teresa Griffin Cascino ◽  
Jay Mandrekar ◽  
W. Richard Marsh ◽  
Frederic B. Meyer ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
Focal Epilepsy ◽  
Drug Resistant ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Epilepsy In Women

scholarly journals The Epilepsy Surgery Grading Scale: Validation in an independent population with drug‐resistant focal epilepsy

Epilepsia ◽  
2019 ◽  
Vol 60 (8) ◽  
Author(s):  
Francesca Conte ◽  
Wim Van Paesschen ◽  
Benjamin Legros ◽  
Chantal Depondt
Keyword(s):  
Epilepsy Surgery ◽  
Scale Validation ◽  
Focal Epilepsy ◽  
Drug Resistant ◽  
Independent Population ◽  
Grading Scale

scholarly journals High-frequency oscillations in scalp EEG mirror seizure frequency in pediatric focal epilepsy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ece Boran ◽  
Johannes Sarnthein ◽  
Niklaus Krayenbühl ◽  
Georgia Ramantani ◽  
Tommaso Fedele
Keyword(s):  
Seizure Frequency ◽  
Epilepsy Surgery ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Low Noise ◽  
Drug Resistant ◽  
Scalp Eeg ◽  
High Frequency Oscillations ◽  
Custom Made ◽  
Active Epilepsy

Abstract High-frequency oscillations (HFO) are promising EEG biomarkers of epileptogenicity. While the evidence supporting their significance derives mainly from invasive recordings, recent studies have extended these observations to HFO recorded in the widely accessible scalp EEG. Here, we investigated whether scalp HFO in drug-resistant focal epilepsy correspond to epilepsy severity and how they are affected by surgical therapy. In eleven children with drug-resistant focal epilepsy that underwent epilepsy surgery, we prospectively recorded pre- and postsurgical scalp EEG with a custom-made low-noise amplifier (LNA). In four of these children, we also recorded intraoperative electrocorticography (ECoG). To detect clinically relevant HFO, we applied a previously validated automated detector. Scalp HFO rates showed a significant positive correlation with seizure frequency (R2 = 0.80, p < 0.001). Overall, scalp HFO rates were higher in patients with active epilepsy (19 recordings, p = 0.0066, PPV = 86%, NPV = 80%, accuracy = 84% CI [62% 94%]) and decreased following successful epilepsy surgery. The location of the highest HFO rates in scalp EEG matched the location of the highest HFO rates in ECoG. This study is the first step towards using non-invasively recorded scalp HFO to monitor disease severity in patients affected by epilepsy.

scholarly journals Epilepsy in women of childbearing age.

BMJ ◽  
1989 ◽  
Vol 299 (6708) ◽  
pp. 1163-1164 ◽  
Author(s):  
D. Chadwick
Keyword(s):  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Epilepsy In Women

Resective Epilepsy Surgery for Drug-Resistant Focal Epilepsy

JAMA ◽  
2015 ◽  
Vol 313 (3) ◽  
pp. 285 ◽  
Author(s):  
Barbara C. Jobst ◽  
Gregory D. Cascino
Keyword(s):  
Epilepsy Surgery ◽  
Focal Epilepsy ◽  
Drug Resistant

scholarly journals Epilepsy in women of childbearing age.

BMJ ◽  
1989 ◽  
Vol 299 (6699) ◽  
pp. 581-581 ◽  
Author(s):  
M. Saunders
Keyword(s):  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Epilepsy In Women
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