019 — (DAS0163) Prognostic significance of interictal spikes and high-frequency oscillations in ECoG acutely recorded during temporal lobe epilepsy surgery

2014 ◽  
Vol 38 ◽  
pp. 189
Author(s):  
A.B. da Silva ◽  
T. Ferrari-Marinho ◽  
L.O. Caboclo ◽  
E.M. Yacubian ◽  
C.M. Queiroz
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
High Frequency ◽  
Prognostic Significance ◽  
Interictal Spikes ◽  
High Frequency Oscillations

scholarly journals Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy

2014 ◽  
Vol 67 ◽  
pp. 97-106 ◽  
Author(s):  
Pariya Salami ◽  
Maxime Lévesque ◽  
Ruba Benini ◽  
Charles Behr ◽  
Jean Gotman ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Interictal Spikes ◽  
High Frequency Oscillations

scholarly journals Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Shennan Aibel Weiss ◽  
Catalina Alvarado-Rojas ◽  
Anatol Bragin ◽  
Eric Behnke ◽  
Tony Fields ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Local Field ◽  
Unit Activity ◽  
High Frequency ◽  
Local Field Potentials ◽  
Mesial Temporal Lobe Epilepsy ◽  
Field Potentials ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy

2019 ◽  
Vol 130 (7) ◽  
pp. 1151-1159 ◽  
Author(s):  
Pavel Řehulka ◽  
Jan Cimbálník ◽  
Martin Pail ◽  
Jan Chrastina ◽  
Markéta Hermanová ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Ictal Occurrence of High-Frequency Oscillations Correlates With Seizure Severity in a Rat Model of Temporal Lobe Epilepsy

2021 ◽  
Vol 15 ◽  
Author(s):  
Nadja Birk ◽  
Jan Schönberger ◽  
Karin Helene Somerlik-Fuchs ◽  
Andreas Schulze-Bonhage ◽  
Julia Jacobs
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Epileptic Activity ◽  
Seizure Severity ◽  
Chronic Epilepsy ◽  
High Frequency Oscillations

High-frequency oscillations (HFOs, ripples 80–250 Hz, fast ripples 250–500 Hz) are biomarkers of epileptic tissue. They are most commonly observed over areas generating seizures and increase in occurrence during the ictal compared to the interictal period. It has been hypothesized that their rate correlates with the severity of epilepsy and seizure in affected individuals. In the present study, it was aimed to investigate whether the HFO count mirrors the observed behavioral seizure severity using a kainate rat model for temporal lobe epilepsy. Seizures were selected during the chronic epilepsy phase of this model and classified by behavioral severity according to the Racine scale. Seizures with Racine scale 5&6 were considered generalized and severe. HFOs were marked in 24 seizures during a preictal, ictal, and postictal EEG segment. The duration covered by the HFO during these different segments was analyzed and compared between mild and severe seizures. HFOs were significantly increased during ictal periods (p < 0.001) and significantly decreased during postictal periods (p < 0.03) compared to the ictal segment. Ictal ripples (p = 0.04) as well as fast ripples (p = 0.02) were significantly higher in severe seizures compared to mild seizures. The present study demonstrates that ictal HFO occurrence mirrors seizure severity in a chronic focal epilepsy model in rats. This is similar to recent observations in patients with refractory mesio-temporal lobe epilepsy. Moreover, postictal HFO decrease might reflect postictal inhibition of epileptic activity. Overall results provide additional evidence that HFOs can be used as biomarkers for measuring seizure severity in epilepsy.

scholarly journals Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy

2021 ◽  
Vol 15 ◽  
Author(s):  
Thato Mary Mokhothu ◽  
Kazumasa Zen Tanaka
Keyword(s):  
Animal Models ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Epileptic Seizures ◽  
Salient Feature ◽  
Future Studies ◽  
High Frequency Oscillations ◽  
Arduous Task ◽  
Brain Hyperexcitability

Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epileptic seizures, and it is usually the focus of TLE. Researchers have identified hippocampal high-frequency oscillations (HFOs) as a salient feature in people with TLE and animal models of this disease, arising before or at the onset of the epileptic event. To a certain extent, these pathological HFOs have served as a marker and a potential target for seizure attenuation using electrical or optogenetic interventions. However, many questions remain about whether we can reliably distinguish pathological from non-pathological HFOs and whether they can tell us about the development of the disease. While this would be an arduous task to perform in humans, animal models of TLE provide an excellent opportunity to study the characteristics of HFOs in predicting how epilepsy evolves. This minireview will (1) summarize what we know about the oscillatory disruption in TLE, (2) summarize knowledge about oscillatory changes in the latent period and their role in predicting seizures, and (3) propose future studies essential to uncovering potential treatments based on early detection of pathological HFOs.

Spatial localization and time-dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy

Epilepsia ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 605-616 ◽  
Author(s):  
Houman Khosravani ◽  
Nikhil Mehrotra ◽  
Michael Rigby ◽  
Walter J. Hader ◽  
C. Robert Pinnegar ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Spatial Localization ◽  
High Frequency Oscillations ◽  
Human Temporal Lobe

scholarly journals Effects of sevoflurane anesthesia on intraoperative high-frequency oscillations in patients with temporal lobe epilepsy

Seizure ◽  
2020 ◽  
Vol 82 ◽  
pp. 44-49
Author(s):  
Asumi Orihara ◽  
Keiko Hara ◽  
Shoko Hara ◽  
Kazuhide Shimizu ◽  
Motoki Inaji ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Sevoflurane Anesthesia ◽  
High Frequency Oscillations

scholarly journals High frequency oscillations in limbic rat model for temporal lobe epilepsy

2007 ◽  
Vol 8 (Suppl 2) ◽  
pp. P145
Author(s):  
Sachin S Talathi ◽  
Dong-Uk Hwang ◽  
William Ditto ◽  
Stephen Myers ◽  
Jennifer Simonotto ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
High Frequency ◽  
High Frequency Oscillations
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