Serotonin transporter gene×environment and risk of depression in community-treated epilepsy

2014 ◽  
Vol 39 ◽  
pp. 33-37 ◽  
Author(s):  
Cameron J. Lacey ◽  
Michael R. Salzberg ◽  
Wendyl J. D'Souza
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Gene Environment

scholarly journals The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

2020 ◽  
Author(s):  
Andrea Bonassi ◽  
Ilaria Cataldo ◽  
Giulio Gabrieli ◽  
Moses Tandiono ◽  
Jia Nee Foo ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Social Desirability ◽  
Parental Bonding ◽  
Serotonin Transporter Gene ◽  
Individual Development ◽  
Environment Interaction ◽  
Transporter Gene ◽  
Gene Environment ◽  
The Impact ◽  
Desirability Index

Human social interactions ensure recognition and approval from others, both in offline and online environments. This study applies a model from behavioural genetics on Instagram sociability to explore the impact of individual development on the behaviour on social networks.We hypothesize that sociable attitudes on Instagram resulted from an interaction between serotonin transporter gene alleles and the individual’s social relationship with caregivers. We assess environmental and genetic components of 57 Instagram users. The self-report questionnaire Parental Bonding Instrument is adopted to determine the quality of parental bonding. The number of posts, followed users (“followings”), and followers are collected from Instagram as measures of online social activity. Additionally, the ratio between the number of followers and followings (“Social Desirability Index”) was calculated to estimate the asymmetry of each user’s social network. Finally, buccal mucosa cell samples were acquired, and the polymorphism rs25531 (T/T homozygotes vs C-carriers) within the serotonin transporter gene was examined.In the preliminary analysis, we identified a gender effect on the number of followings. In line with our predictions, we specifically found a gene- environment interaction on the standardized Instagram “Social Desirability Index”: users with the genotype more sensitive to environmental influences (T/T homozygotes) showed a higher Instagram “Social Desirability Index” than non-sensitive ones (C-carriers) when they experienced positive maternal care.This result may contribute to the understanding of online social behaviour from a gene*environment perspective.

Loneliness in adolescence: gene × environment interactions involving the serotonin transporter gene

2010 ◽  
Vol 51 (7) ◽  
pp. 747-754 ◽  
Author(s):  
Eeske Van Roekel ◽  
Ron H.J. Scholte ◽  
Maaike Verhagen ◽  
Luc Goossens ◽  
Rutger C.M.E. Engels
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Gene Environment

High Work Demands and Depression: The Moderating Role of the Serotonin Transporter Gene (5-HTT) and Work Control

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
M. Melchior ◽  
T.E. Moffitt ◽  
R. Poulton ◽  
K. Sugden ◽  
A. Caspi
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Environment Interaction ◽  
Work Demands ◽  
Transporter Gene ◽  
Work Control ◽  
Gene Environment Interaction ◽  
Symptoms Of Depression ◽  
Gene Environment ◽  
High Work

Background:High work demands (i.e. a heavy workload, tight time pressures, conflicting work tasks) put individuals at high risk of depression. Our aim was to test whether the relationship between high work demands and depression is moderated by genetic vulnerability to depression and by work control.Methods:Participants are members of the Dunedin Study, a 1972-73 longitudinal birth cohort assessed most recently in 2004-2005, at age 32 (96% response rate). This analysis included all participants who were employed at age 32. Depression was measured using the Diagnostic Interview Schedule. Work demands and work control were assessed in an interview. Genetic vulnerability to stress was ascertained by the serotonin transporter gene (5-HTT).Results:Among individuals exposed to high work demands, symptoms of depression were significantly higher among those who carried two short alleles of the 5-HTT gene (‘s/s’ group) than among ‘l’ carriers (interaction between 5-HTT gene and work demands: β=4.22, se=1.86, p=0.02). However, this gene-environment interaction was only present among those individuals who had low control over their work (interaction between 5-HTT gene and high work demands: β: 7.21, se: 2.73, p=0.009), not among those who had high work control (interaction between 5-HTT gene and high work demands: β: 1.32, se: 2.53, p=0.60).Conclusion:Pending replication, the serotonin transporter gene appears to moderate the effects of high work demands on symptoms of depression. This gene-environment interaction is attenuated by high work control.

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