Ictal singing due to left frontal lobe epilepsy: A case report and review of the literature

2011 ◽  
Vol 22 (2) ◽  
pp. 404-406 ◽  
Author(s):  
Rei Enatsu ◽  
Stephen Hantus ◽  
Jorge Gonzalez-Martinez ◽  
Norman So
2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
A. Verentzioti ◽  
I. Blumcke ◽  
A. Alexoudi ◽  
P. Patrikelis ◽  
A. Siatouni ◽  
...  

Introduction. There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy). We report the case of an epileptic patient with MOGHE. Case Report. A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence. MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE appears to be a brain entity which shares some unique histopathological features. Review of the literature is in accordance with our patient’s findings. The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation. MR abnormalities are present in T2/FLAIR sequences. It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control. Conclusion. More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy. This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery.


2017 ◽  
Vol 8 ◽  
pp. 27-30 ◽  
Author(s):  
Guray Koc ◽  
Semai Bek ◽  
Zeki Gokcil

Author(s):  
Joyce JG ◽  
O’Dowd M ◽  
Ryan RS ◽  
Stokes HS ◽  
ONeill MB

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1616-1619 ◽  
Author(s):  
Yang-Je Cho ◽  
Sang-Don Han ◽  
Sook Keun Song ◽  
Byung In Lee ◽  
Kyoung Heo

2014 ◽  
Vol 54 (7) ◽  
pp. 593-597 ◽  
Author(s):  
Noriaki MINAMI ◽  
Takehiro UDA ◽  
Takahiro MATSUMOTO ◽  
Taiki NAGAI ◽  
Tatsuya UCHIDA ◽  
...  

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi99-vi99
Author(s):  
Kyu Sang Lee ◽  
Gheeyoung Choe

Abstract Primary glioblastoma develops de novo without clinical or histological evidence of a low-grade precursor lesion, while secondary glioblastoma develops from a low-grade glioma. The same IDH mutation is observed in almost secondary glioblastomas that occurs in low-grade gliomas with IDH mutation. Present report is an extraordinary case of secondary glioblastoma, IDH-wildtype arising in diffuse astrocytoma, IDH-mutant. A 31-year-old female presented with seizure 3 months ago, who had a history of operation for diffuse astrocytoma, IDH-mutant on the left frontal lobe 6 years ago. Magnetic resonance imaging test revealed new infiltrative lesions (6.5cm) in left frontal lobe and corpus callosum, in addition to the non-enhancing mass (3.4cm). New infiltrative lesion suspected anaplastic change and the patient underwent tumorectomy. Microscopically, non-enhancing lesion showed high cellularity, moderate nuclear atypia and brisk mitosis. Microvascular proliferation and necrosis were absent that can be diagnosis as anaplastic astrocytoma. However, new infiltrative lesion showed microvascular proliferation and necrosis that acceptable for diagnosis as glioblastoma. IDH-1 immunohistochemistry (IHC) was positive in anaplastic astrocytoma but negative in glioblastoma. In addition, we assessed NGS based on the SNUBH Brain v1.0 (Macrogen, Seoul, South Korea) panel. Similar to IHC result, IDH-1 (p.Arg132His) mutation was found in anaplastic astrocytoma but not in glioblastoma. Interestingly, ATRX (p.Gln1670Ter) and TP53 (p.His193Arg) mutations were found in both lesions. Additionally, PTEN (p.His296Pro) mutation was identified in glioblastoma component only. Until now, it is well-known hypothesis that the IDH mutation initiated in glial progenitor cell and the other genetic mutations occur sequentially in pathogenesis of secondary glioblastoma. Notably, this is the first case report that other genetic alterations can be initiated before IDH mutation contrary to previous hypothesis. In our case, mutation of ATRX and TP53 might be initiated, and PTEN and IDH-1 mutations were sequentially occurred in glioblastoma and anaplastic astrocytoma, respectively.


2002 ◽  
Vol 1232 ◽  
pp. 661-665 ◽  
Author(s):  
A. Fujimoto ◽  
T. Enomoto ◽  
A. Matsumura ◽  
T. Yoshizawa ◽  
T. Nose

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