Histological regression in primary melanoma: not a predictor of sentinel lymph node metastasis in a cohort of 397 patients

2011 ◽  
Vol 2011 ◽  
pp. 384-385
Author(s):  
E.M. Billingsley
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Primary Melanoma ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis ◽  
Histological Regression

scholarly journals Absence of Granzyme B Positive Tumour-Infiltrating Lymphocytes in Primary Melanoma Excisional Biopsies is Strongly Associated with the Presence of Sentinel Lymph Node Metastasis

2009 ◽  
Vol 31 (5) ◽  
pp. 407-413
Author(s):  
I. S. van Houdt ◽  
B. J. R. Sluijter ◽  
P. A. M. van Leeuwen ◽  
L. M. Moesbergen ◽  
E. Hooijberg ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Granzyme B ◽  
Primary Melanoma ◽  
Sentinel Lymph Node Metastasis ◽  
Mhc I ◽  
Node Metastasis ◽  
Melanoma Patients ◽  
Infiltrating Lymphocytes

Background: Sentinel Lymph Node (SLN) status is strongly related to clinical outcome in melanoma patients. In this study we investigated the possible association between the presence of activated and/or suppressive Tumour Infiltrating Lymphocytes (TILs) and SLN status in clinically stage I/II melanoma patients.Methods: Diagnostic primary melanoma samples from 20 patients with a sentinel lymph node metastasis were compared to melanoma samples from 20 patients with a negative sentinel lymph node, who were matched for gender, age and Breslow thickness. Presence of activated Granzyme B positive (GrB+) TILs, presence of suppressive (FoxP3+) TILs and MHC class I antigen expression on tumour cells were analysed by immunohistochemistry.Results: FoxP3 and MHC-I expression had no direct bearing on the presence of melanoma metastases in the SLN. Whereas the presence of activated GrB+ TILs in the primary melanoma had no predictive value for SLN status either, their absence was strongly associated with the presence of metastasis in the SLN (p=0.001). While both GrB+ and FoxP3+ TILs could be detected in SLN metastases, a majority did not display MHC-I expression.Conclusions: These data support a role for cytotoxic T cells in the prevention of early metastasis of melanoma to the draining lymph nodes.

Age and Mitogenicity are Important Predictors of Sentinel Lymph Node Metastasis in T1a Melanoma

2021 ◽  
Author(s):  
Adrienne B. Shannon ◽  
Christian Wood ◽  
Richard J. Straker ◽  
John T. Miura ◽  
Michael E. Ming ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis

scholarly journals Nuclear Odontogenic Ameloblast-Associated Protein (ODAM) Correlates with Melanoma Sentinel Lymph Node Metastasis

2013 ◽  
Vol 04 (08) ◽  
pp. 1283-1289 ◽  
Author(s):  
Sagar S. Gandhi ◽  
Daniel P. Kestler ◽  
Charles T. Bruker ◽  
James M. McLaughlin ◽  
Robert E. Heidel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis

scholarly journals Molecular Diagnosis of the Sentinel Lymph Node Metastasis in Patients with Malignant Melanoma

2004 ◽  
Vol 54 (3) ◽  
pp. 209-214
Author(s):  
Atsushi Tamura ◽  
Yukie Endo ◽  
Sachiko Ogino ◽  
Yuko Takeuchi ◽  
Yayoi Nagai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Malignant Melanoma ◽  
Lymph Node Metastasis ◽  
Molecular Diagnosis ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis
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