scholarly journals SWAN: A distributed knowledge infrastructure for Alzheimer disease research

2006 ◽  
Vol 4 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Yong Gao ◽  
June Kinoshita ◽  
Elizabeth Wu ◽  
Eric Miller ◽  
Ryan Lee ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Distributed Knowledge ◽  
Disease Research ◽  
Knowledge Infrastructure

scholarly journals SWAN: A Distributed Knowledge Infrastructure for Alzheimer Disease Research

2006 ◽  
Author(s):  
Yong Gao ◽  
June Kinoshita ◽  
Elizabeth Wu ◽  
Eric Miller ◽  
Ryan Lee ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Distributed Knowledge ◽  
Disease Research ◽  
Knowledge Infrastructure

scholarly journals A Simplified Brain Blocking Protocol Optimized for the Diagnosis of Neurodegenerative Disease Saves Time and Money While Preserving Anatomic Relationships

2020 ◽  
Author(s):  
Nathan F. Clement ◽  
John C. DeWitt ◽  
Matthew P. Frosch ◽  
Maria Martinez-Lage ◽  
Wesley R. Samore ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Alzheimer Disease ◽  
Neurodegenerative Disease ◽  
Corticobasal Degeneration ◽  
Amyloid Angiopathy ◽  
Standard Protocol ◽  
Lewy Pathology ◽  
Disease Research ◽  
Sampling Protocols ◽  
Cerebral Amyloid

Context.— Postmortem evaluation for neurodegenerative disease is expensive in time and materials. These challenges can be met by implementing simpler sampling protocols while preserving anatomic relations. Objective.— To determine the diagnostic effectiveness and cost-effectiveness of a simplified brain blocking protocol compared with the standard blocking protocol used in our Alzheimer disease research center (ADRC). Design.— We prospectively compared the neuropathologic diagnoses established from our standard 19-cassette/19 brain sites ADRC protocol to a simplified 6-cassette/12 brain sites protocol in 52 consecutive cases. The simplified protocol generated 14 slides for comparison to 52 slides from our standard protocol. Results.— Compared with the ADRC protocol the simplified protocol produced Alzheimer Disease Neuropathologic Changes probability scores that were the same in 50 of 52 cases (r = 0.99). Staging for Lewy pathology was equivalent in 45 of 52 (r = 0.98), scoring for cerebral amyloid angiopathy was equivalent in 48 of 52 (r = 0.97), and grading for arteriolosclerosis was the same in 45 of 52 cases (r = 0.92). Progressive supranuclear palsy (n = 4), multiple system atrophy (n = 2), and corticobasal degeneration (n = 1) could be diagnosed by either protocol independently. The estimated savings per case was 72% or $1744.89 ($2436.37 [ADRC] versus $691.48 [simplified]). Conclusions.— The diagnosis of neurodegenerative disease at autopsy can be done accurately with a less expensive, simplified protocol. Our protocol is similar to those of previously published approaches, but it has a simpler organization scheme. This method should be valuable to institutions where autopsy cost considerations may be important.

A Collaborative Alzheimer Disease Research Exchange

2010 ◽  
pp. 1
Author(s):  
Mary Guerriero Austrom ◽  
Jennifer Bachman ◽  
Linda Altmeyer ◽  
Sujuan Gao ◽  
Martin Farlow
Keyword(s):  
Alzheimer Disease ◽  
Disease Research

scholarly journals Retention of Alzheimer Disease Research Participants

2019 ◽  
Vol 33 (4) ◽  
pp. 299-306 ◽  
Author(s):  
Joshua D. Grill ◽  
Jimmy Kwon ◽  
Merilee A. Teylan ◽  
Aimee Pierce ◽  
Eric D. Vidoni ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Research Participants ◽  
Disease Research

The Quandary of Reductionism: Relevance to Alzheimer Disease Research

2002 ◽  
Vol 4 (6) ◽  
pp. 531-537 ◽  
Author(s):  
Sharon Moalem ◽  
Maire E. Percy
Keyword(s):  
Alzheimer Disease ◽  
Disease Research

Gamma-Secretase as a Pharmacological Target in Alzheimer Disease Research: When, Why and How?

2006 ◽  
Vol 12 (33) ◽  
pp. 4313-4335 ◽  
Author(s):  
Chewki Ziani-Cherif ◽  
Bachir Mostefa-Kara ◽  
Fatima Brixi-Gormat
Keyword(s):  
Alzheimer Disease ◽  
Gamma Secretase ◽  
Disease Research ◽  
Pharmacological Target
Sign in / Sign up

Export Citation Format

Share Document