Endothelial Wnt/β-catenin signaling reduces vascularization, barrier breakdown and tumor growth in a mouse glioma model

2012 ◽  
Vol 56 (5-6) ◽  
pp. 332
Author(s):  
Marco Reis ◽  
Cathrin J. Czupalla ◽  
Nicole Ziegler ◽  
Kavi Devraj ◽  
Sascha Seidel ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Barrier Breakdown ◽  
Glioma Model ◽  
Mouse Glioma

scholarly journals Targeting CD146 using folic acid–conjugated nanoparticles and suppression of tumor growth in a mouse glioma model

2020 ◽  
pp. 1-11
Author(s):  
Naoki Fukui ◽  
Toshio Yawata ◽  
Takahito Nakajo ◽  
Yu Kawanishi ◽  
Youichirou Higashi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Folic Acid ◽  
Tumor Growth ◽  
In Vivo Imaging ◽  
Water Soluble ◽  
Therapeutic Effects ◽  
Glioma Model ◽  
Mouse Glioma

OBJECTIVEGlioma stem cells (GSCs) are responsible for tumor initiation, therapeutic resistance, and recurrence. CD146 is mainly expressed in dividing GSCs and regulates cell cycle progression. However, the evaluation of the efficacy of targeted therapy against CD146 in vivo remains to be investigated. In this study, the authors aimed to develop gene therapy targeting GSCs using chitosan oligosaccharide lactate (COL) nanoparticles (NPs) conjugated with folic acid–polyethylene glycol (FA-PEG-COL NPs) for in vitro and in vivo delivery of CD146 small-interfering RNA (siCD146) and to determine the effect of CD146 knockdown on tumor growth.METHODSTo examine the uptake of NPs by tumor cells, immunofluorescence staining, flow cytometry, and in vivo imaging were performed. The knockdown effect of siCD146 was measured by western blot and water-soluble tetrazolium salt–8 assay in mouse glioma cells. The efficacy of siRNA therapy–targeted GSCs was evaluated by monitoring tumor growth through in vivo imaging and histological analysis.RESULTSIn vivo accumulation of the FA-PEG-COL NPs in subcutaneous and intracranial gliomas following NP administration via a mouse tail vein was observed. Additionally, in vitro delivery of siCD146 ionically cross-linked NPs, reduced CD146 levels, and suppressed growth in the glioma tumor sphere. Evaluation of the in vivo therapeutic effects of siCD146–cross-linked NPs in a mouse glioma model revealed significant suppression of intracranial tumor growth, with complete removal of the tumor observed in some mice on histological examination. Furthermore, delivery of siCD146 significantly reduced the Ki-67 index in residual tumor tissues relative to that in control mice.CONCLUSIONSCD146 is a potential therapeutic target, and folic acid–conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas.

PEX-producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

Neurosurgery ◽  
2005 ◽  
Vol 57 (2) ◽  
pp. 411-411
Author(s):  
Seung-Ki Kim ◽  
Peter McL. Black ◽  
Seung U. Kim ◽  
Theresa Cargioli ◽  
Yanping Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Tumor Growth ◽  
Inhibit Tumor Growth ◽  
Human Neural Stem Cells ◽  
Glioma Model ◽  
Mouse Glioma

Abstract 1092: PF562271, a Pyk2 inhibitor, reduces glioma tumor growth and invasion in C57Bl6-Gl261 mouse glioma model

2017 ◽  
Author(s):  
Jescelica Ortiz-Rivera ◽  
Kimberleve Rolón-Reyes ◽  
Alejandro Albors ◽  
Luis Cubano ◽  
Lilia Kucheryavykh
Keyword(s):  
Tumor Growth ◽  
Glioma Tumor ◽  
Glioma Model ◽  
Mouse Glioma ◽  
Tumor Growth And Invasion

scholarly journals Short Hairpin RNA-Mediated Fibronectin Knockdown Delays Tumor Growth in a Mouse Glioma Model

Neoplasia ◽  
2010 ◽  
Vol 12 (10) ◽  
pp. 837-847 ◽  
Author(s):  
Sadhak Sengupta ◽  
Suvobroto Nandi ◽  
Enal S. Hindi ◽  
Derek A. Wainwright ◽  
Yu Han ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Short Hairpin ◽  
Glioma Model ◽  
Mouse Glioma

PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

2005 ◽  
Vol 11 (16) ◽  
pp. 5965-5970 ◽  
Author(s):  
Seung-Ki Kim ◽  
Theresa G. Cargioli ◽  
Marcelle Machluf ◽  
Wendy Yang ◽  
Yanping Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Tumor Growth ◽  
Inhibit Tumor Growth ◽  
Human Neural Stem Cells ◽  
Glioma Model ◽  
Mouse Glioma

scholarly journals Double minute amplification of mutant PDGF receptor α in a mouse glioma model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hongyan Zou ◽  
Rui Feng ◽  
Yong Huang ◽  
Joseph Tripodi ◽  
Vesna Najfeld ◽  
...  
Keyword(s):  
Pdgf Receptor ◽  
Double Minute ◽  
Glioma Model ◽  
Mouse Glioma

scholarly journals A Syngeneic Mouse Glioma Model for Study of Glioblastoma Therapy

1999 ◽  
Vol 58 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Ned E. Weiner ◽  
Richard B. Pyles ◽  
Claudia L. Chalk ◽  
M Gregory Balko ◽  
Mary Ann Miller ◽  
...  
Keyword(s):  
Syngeneic Mouse ◽  
Glioma Model ◽  
Mouse Glioma

scholarly journals Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NFkB/MDR1 pathway

2020 ◽  
Author(s):  
Yoshifumi Mizobuchi ◽  
Kenji Shono ◽  
Izumi Yamaguchi ◽  
Kohei Nakajima ◽  
Yuri Fujiwara ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Surgical Intervention ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Multidrug Resistant ◽  
Down Regulation ◽  
Sonodynamic Therapy ◽  
Glioma Model ◽  
A Site ◽  
Mouse Glioma

Abstract Glioblastoma (GBM) has high mortality rates because of extremely therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) is an emerging and promising approach combined with low-intensity ultrasonication (US) and PpIX as a sonosensitizer for cancer, whereas its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, a MDR1 inhibitor and augmented anti-tumor effects of SDT. MDR1 down-regulation via Akt/NF-kB pathway by celecoxib was confirmed, using a NF-kB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via Akt/NF-kB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM.

MIP-1  Antagonizes the Effect of a GM-CSF-Enhanced Subcutaneous Vaccine in a Mouse Glioma Model

2004 ◽  
Vol 66 (1/2) ◽  
pp. 147-154 ◽  
Author(s):  
Ulrich Herrlinger ◽  
Steffen Aulwurm ◽  
Herwig Strik ◽  
Simone Weit ◽  
Ulrike Naumann ◽  
...  
Keyword(s):  
Gm Csf ◽  
Glioma Model ◽  
Mouse Glioma
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