Effect of A2a purinoceptors stimulation on l-arginine transport and nitric oxide synthesis in placental microvascular endothelial cells from women with preeclampsia

2006 ◽  
Vol 45 (3) ◽  
pp. e153
Author(s):  
Carlos Escudero ◽  
Paola Casanello ◽  
Luis Sobrevia
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cells ◽  
Nitric Oxide Synthesis ◽  
Arginine Transport ◽  
Microvascular Endothelial

scholarly journals Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

2019 ◽  
Vol 8 (6) ◽  
pp. 918-927 ◽  
Author(s):  
Li Pang ◽  
Ping Deng ◽  
Yi-dan Liang ◽  
Jing-yu Qian ◽  
Li-Chuan Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Endothelial Cells ◽  
Endothelial Dysfunction ◽  
Lipoic Acid ◽  
Microvascular Endothelial Cells ◽  
Ros Generation ◽  
Protective Effects ◽  
Migration Ability ◽  
Microvascular Endothelial

Abstract Paraquat (PQ) is a widely used herbicide in the agricultural field. The lack of an effective antidote is the significant cause of high mortality in PQ poisoning. Here, we investigate the antagonistic effects of alpha lipoic acid (α-LA), a naturally existing antioxidant, on PQ toxicity in human microvascular endothelial cells (HMEC-1). All the doses of 250, 500 and 1000 μM α-LA significantly inhibited 1000 μM PQ-induced cytotoxicity in HMEC-1 cells. α-LA pretreatment remarkably diminished the damage to cell migration ability, recovered the declined levels of the vasodilator factor nitric oxide (NO), elevated the expression level of endothelial nitric oxide synthases (eNOS), and inhibited the upregulated expression of vasoconstrictor factor endothelin-1 (ET-1). Moreover, α-LA pretreatment inhibited reactive oxygen species (ROS) generation, suppressed the damage to the mitochondrial membrane potential (ΔΨm) and mitigated the inhibition of adenosine triphosphate (ATP) production in HMEC-1 cells. These results suggested that α-LA could alleviate PQ-induced endothelial dysfunction by suppressing oxidative stress. In summary, our present study provides novel insight into the protective effects and pharmacological potential of α-LA against PQ toxicity in microvascular endothelial cells.

Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma

2000 ◽  
Vol 5 (3) ◽  
pp. 147-158 ◽  
Author(s):  
L.I. Romero ◽  
D-N. Zhang ◽  
J.P. Cooke ◽  
H-K. V Ho ◽  
E. Avalos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Differential Expression ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial

scholarly journals Nitric oxide signaling in adipose triglyceride lipase-deficient microvascular endothelial cells

2012 ◽  
Vol 13 (Suppl 1) ◽  
pp. A22
Author(s):  
Marion Mussbacher ◽  
Sarah Winkler ◽  
Günter Hämmerle ◽  
Rudolf Zechner ◽  
Bernd Mayer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Microvascular Endothelial Cells ◽  
Adipose Triglyceride Lipase ◽  
Nitric Oxide Signaling ◽  
Triglyceride Lipase ◽  
Microvascular Endothelial

scholarly journals Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells

Cytokine ◽  
2011 ◽  
Vol 54 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Bojana B. Beleslin-Čokić ◽  
Vladan P. Čokić ◽  
Li Wang ◽  
Barbora Piknova ◽  
Ruifeng Teng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Erythropoietin Receptor ◽  
Microvascular Endothelial Cells ◽  
Microvascular Endothelial
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