Effect of anti-oxidative enzyme gene-transfer on endothelial cell function of apolipoprotein-E deficient mice

2006 ◽  
Vol 45 (3) ◽  
pp. e73-e74
Author(s):  
P-J. Guns ◽  
T. Van Assche ◽  
W. Verreth ◽  
P. Fransen ◽  
B. Mackness ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Gene Transfer ◽  
Apolipoprotein E ◽  
Cell Function ◽  
Oxidative Enzyme ◽  
Endothelial Cell Function ◽  
Enzyme Gene ◽  
Deficient Mice

Endothelial cell function in the aorta of apolipoprotein E-deficient mice before the development of atheroslcerotic lesions

2006 ◽  
Vol 45 (3) ◽  
pp. e96
Author(s):  
Paul Fransen ◽  
Tim Van Assche ◽  
Pieter-Jan Guns ◽  
Jan Hendrickx ◽  
Cor E. Van Hove ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Apolipoprotein E ◽  
Cell Function ◽  
Endothelial Cell Function ◽  
Deficient Mice

scholarly journals The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Xiaona Xu ◽  
Zhiqiang Zhao ◽  
Guangping Li
Keyword(s):  
Endothelial Cell ◽  
Apolipoprotein E ◽  
Aortic Arch ◽  
Cell Function ◽  
Blood Lipid ◽  
Endothelial Damage ◽  
Endothelial Cell Function ◽  
Plaque Instability ◽  
Endothelial Cell Death ◽  
Deficient Mice

Vascular calcification is an independent risk factor for plaque instability and is associated with endothelial cell function. Here, we investigated the role of endothelial cell function in the calcification of atherosclerotic plaques. We hypothesized that atherosclerosis would be associated with endothelial dysfunction and that bosentan (Tracleer®), a dual endothelin-receptor antagonist, would preserve endothelial cell function in an apolipoprotein E-deficient (ApoE−/−) mouse model of atherosclerosis. Accordingly, 4–6-week-old ApoE−/− mice were fed a high-fat diet and treated with bosentan, and the effects of this treatment on body weight and blood lipid concentrations was evaluated. Endothelial damage in the aortic arch was assessed immunohistochemically to detect the proapoptotic proteins PDCD4, caspase-3, and Bax and the antiapoptotic protein Bcl-2. Notably, bosentan treatment was associated with decreased concentrations of these proteins and of blood lipids in ApoE−/− mice. Consistent with these findings, we observed increased concentrations of miRNA-21 and PDCD4 mRNA expression in the aortic arch endothelium after bosentan treatment. We conclude that bosentan can prevent endothelial cell death and protect against atherosclerosis in ApoE-deficient mice by upregulating miRNA-21.

Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice

Blood ◽  
2001 ◽  
Vol 98 (9) ◽  
pp. 2869-2871 ◽  
Author(s):  
Shigeru Yanagi ◽  
Ryoko Inatome ◽  
Junyi Ding ◽  
Hironori Kitaguchi ◽  
Victor L. J. Tybulewicz ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Function ◽  
Critical Role ◽  
Microscopic Analysis ◽  
Electron Microscopic ◽  
Vascular Integrity ◽  
Endothelial Cell Function ◽  
Deficient Mice

Abstract Mice deficient in the Syk tyrosine kinase showed severe petechiae in utero and died shortly after birth. The mechanism of this bleeding, however, remains unknown. Here it is shown that this bleeding is caused by morphologic defects of Syk-deficient endothelial cells during embryogenesis. Immunoblot and reverse transcriptase–polymerase chain reaction Northern blot analysis indicated that Syk is expressed in several endothelial cell lines. Immunocytochemical analysis also confirmed that Syk is expressed in the normal embryonic endothelial cells and is absent in Syk-deficient mice. Furthermore, electron microscopic analysis of Syk-deficient mice revealed an abnormal morphogenesis and a decreased number of endothelial cells. The results indicate a critical role for Syk in endothelial cell function and in maintaining vascular integrity in vivo.

Do DPP-4 inhibitors improve endothelial cell function?

2017 ◽  
Vol 01 (01) ◽  
Author(s):  
Hiroshi Nomoto ◽  
Hideaki Miyoshi ◽  
Akinobu Nakamura ◽  
Tatsuya Atsumi ◽  
Naoki Manda ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Function ◽  
Endothelial Cell Function

Estrogen Restores Endothelial Cell Function in an Experimental Model of Vascular Injury

Circulation ◽  
1997 ◽  
Vol 96 (5) ◽  
pp. 1624-1630 ◽  
Author(s):  
C. Roger White ◽  
Jonathan Shelton ◽  
Shi-Juan Chen ◽  
Victor Darley-Usmar ◽  
Leslie Allen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Experimental Model ◽  
Vascular Injury ◽  
Cell Function ◽  
Endothelial Cell Function

scholarly journals Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia

2017 ◽  
Vol 232 (1) ◽  
pp. R27-R44 ◽  
Author(s):  
D S Boeldt ◽  
I M Bird
Keyword(s):  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Cell Function ◽  
Endothelial Cell Dysfunction ◽  
Hypertensive Disorders Of Pregnancy ◽  
Endothelial Cell Function ◽  
Vascular Adaptation ◽  
Cell Dysfunction ◽  
Maternal Adaptation ◽  
Flow Through

Maternal vascular adaptation to pregnancy is critically important to expand the capacity for blood flow through the uteroplacental unit to meet the needs of the developing fetus. Failure of the maternal vasculature to properly adapt can result in hypertensive disorders of pregnancy such as preeclampsia (PE). Herein, we review the endocrinology of maternal adaptation to pregnancy and contrast this with that of PE. Our focus is specifically on those hormones that directly influence endothelial cell function and dysfunction, as endothelial cell dysfunction is a hallmark of PE. A variety of growth factors and cytokines are present in normal vascular adaptation to pregnancy. However, they have also been shown to be circulating at abnormal levels in PE pregnancies. Many of these factors promote endothelial dysfunction when present at abnormal levels by acutely inhibiting key Ca2+ signaling events and chronically promoting the breakdown of endothelial cell–cell contacts. Increasingly, our understanding of how the contributions of the placenta, immune cells, and the endothelium itself promote the endocrine milieu of PE is becoming clearer. We then describe in detail how the complex endocrine environment of PE affects endothelial cell function, why this has contributed to the difficulty in fully understanding and treating this disorder, and how a focus on signaling convergence points of many hormones may be a more successful treatment strategy.

Shear stress regulates endothelial cell function through SRB1-eNOS signaling pathway

2016 ◽  
Vol 34 (5) ◽  
pp. 308-313 ◽  
Author(s):  
Ying Zhang ◽  
Bin Liao ◽  
Miaoling Li ◽  
Min Cheng ◽  
Yong Fu ◽  
...  
Keyword(s):  
Shear Stress ◽  
Endothelial Cell ◽  
Signaling Pathway ◽  
Cell Function ◽  
Endothelial Cell Function

Hypothermic machine perfusion of rat livers preserves endothelial cell function

2005 ◽  
Vol 37 (1) ◽  
pp. 335-337 ◽  
Author(s):  
H. Xu ◽  
J.X. Zhang ◽  
J.W. Jones ◽  
J.H. Southard ◽  
M.G. Clemens ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Function ◽  
Machine Perfusion ◽  
Endothelial Cell Function ◽  
Hypothermic Machine Perfusion ◽  
Rat Livers
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