A genome- and biochemistry-based study of vascular endothelial cell–smooth muscle cell interaction in response to shear stress

2006 ◽  
Vol 45 (3) ◽  
pp. e56
Author(s):  
Jeng-Jiann Chiu ◽  
Li-Jing Chen ◽  
Shunichi Usami ◽  
Shu Chien
Keyword(s):  
Shear Stress ◽  
Smooth Muscle ◽  
Endothelial Cell ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Endothelial Cell ◽  
Cell Interaction ◽  
Vascular Endothelial ◽  
A Genome

scholarly journals Yes-Associated Protein in Atherosclerosis and Related Complications: A Potential Therapeutic Target That Requires Further Exploration

2021 ◽  
Vol 8 ◽  
Author(s):  
Congrui Sun ◽  
Bin He ◽  
Mingsheng Sun ◽  
Xiaoshuo Lv ◽  
Feng Wang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Endothelial Cell ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Endothelial Cell ◽  
Atherosclerotic Lesion ◽  
Future Research ◽  
Endothelial Cell Dysfunction ◽  
Cell Dysfunction ◽  
Cardiovascular Morbidity And Mortality

Atherosclerosis and its complications diseases remain leading causes of cardiovascular morbidity and mortality, bringing a massive burden on public health worldwide. Atherosclerosis is recognized as chronic inflammation, and involves several highly correlated processes, including lipid metabolism dysfunction, endothelial cell dysfunction, inflammation, oxidative stress, vascular smooth muscle cell activation, platelet activation, thrombosis, altered matrix metabolism, and vascular remodeling. Within the past few decades, accumulating evidence has shown that the Yes-associated protein (YAP), the major effector of the Hippo pathway, can play a crucial role in pathogenesis and development of atherosclerosis. Activation of YAP-related pathways, which are induced by alerting flow pattern and matrix stiffness among others, can regulate processes including vascular endothelial cell dysfunction, monocyte infiltration, and smooth muscle cell migration, which contribute to atherosclerotic lesion formation. Further, YAP potentially modulates atherosclerotic complications such as vascular calcification and intraplaque hemorrhage, which require further investigation. Here, we summarized the relevant literature to outline current findings detailing the relationship between of YAP and atherosclerosis and highlight areas for future research.

scholarly journals Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

1986 ◽  
Vol 83 (7) ◽  
pp. 2114-2117 ◽  
Author(s):  
P. F. Davies ◽  
A. Remuzzi ◽  
E. J. Gordon ◽  
C. F. Dewey ◽  
M. A. Gimbrone
Keyword(s):  
Shear Stress ◽  
Endothelial Cell ◽  
Fluid Shear Stress ◽  
Vascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Cell Turnover ◽  
Fluid Shear ◽  
Turbulent Fluid
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