Protein kinase Cε (PKCε) regulates BCL-2 expression in vascular endothelial cells (EC) and protects against apoptosis

2006 ◽  
Vol 45 (3) ◽  
pp. 192
Author(s):  
R. Steinberg ◽  
O. Harari ◽  
E. Lidington ◽  
A. Samarel ◽  
M. Ohba ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Ablation of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) in Vascular Endothelial Cells Enhances Insulin Sensitivity by Reducing Visceral Fat and Suppressing Angiogenesis

2012 ◽  
Vol 26 (1) ◽  
pp. 95-109 ◽  
Author(s):  
Kazuhito Tawaramoto ◽  
Ko Kotani ◽  
Mitsuru Hashiramoto ◽  
Yukiko Kanda ◽  
Tomoki Nagare ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Insulin Sensitivity ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Whole Body ◽  
Vascular Endothelial ◽  
Dependent Protein Kinase ◽  
Dependent Protein

Abstract The phosphatidylinositol 3-kinase signaling pathway in vascular endothelial cells is important for systemic angiogenesis and glucose metabolism. In this study, we addressed the precise role of the 3-phosphoinositide-dependent protein kinase 1 (PDK1)-regulated signaling network in endothelial cells in vivo, using vascular endothelial PDK1 knockout (VEPDK1KO) mice. Surprisingly, VEPDK1KO mice manifested enhanced glucose tolerance and whole-body insulin sensitivity due to suppression of their hepatic glucose production with no change in either peripheral glucose disposal or even impaired vascular endothelial function at 6 months of age. When mice were fed a standard diet at 6 months of age and a high-fat diet at 3 months of age, hypertrophy of epididymal adipose tissues was inhibited, adiponectin mRNA was significantly increased, and mRNA of MCP1, leptin, and TNFα was decreased in the white adipose tissue of VEPDK1KO mice in comparison with controls. Consequently, both the circulating adiponectin levels and the activity of hepatic AMP-activated protein kinase were significantly increased, subsequently enhancing whole-body insulin sensitivity and energy expenditure with increased hepatic fatty acid oxidation in VEPDK1KO mice. These results provide the first in vivo evidence that lowered angiogenesis through the deletion of PDK1 signaling not only interferes with the growth of adipose tissue but also induces increased energy expenditure due to amelioration of the adipocytokine profile. This demonstrates an unexpected role of PDK1 signaling in endothelial cells on the maintenance of proper glucose homeostasis through the regulation of adipocyte development.

scholarly journals E-Selectin-Dependent Signaling Via the Mitogen-Activated Protein Kinase Pathway in Vascular Endothelial Cells

2000 ◽  
Vol 165 (4) ◽  
pp. 2142-2148 ◽  
Author(s):  
Yenya Hu ◽  
Jeanne-Marie Kiely ◽  
Brian E. Szente ◽  
Anthony Rosenzweig ◽  
Michael A. Gimbrone
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Vascular Endothelial ◽  
Mitogen Activated Protein ◽  
Kinase Pathway

scholarly journals Cell Growth Regulation through the Protein Kinase C Pathway in Cultured Human Vascular Endothelial Cells

1993 ◽  
Vol 57 (supplementIV) ◽  
pp. 1207-1210 ◽  
Author(s):  
Chiya Kosaka ◽  
Toshiyuki Sasaguri ◽  
Katsuhiro Zen ◽  
Junichi Masuda ◽  
Kentaro Shimokado ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Growth ◽  
Growth Regulation ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Cell Growth Regulation ◽  
Kinase C

Protein Kinase C-Mediated Inhibition of Cyclin A Expression in Human Vascular Endothelial Cells

1993 ◽  
Vol 193 (3) ◽  
pp. 991-998 ◽  
Author(s):  
C. Kosaka ◽  
T. Sasaguri ◽  
J. Masuda ◽  
K. Zen ◽  
K. Shimokado ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Cyclin A ◽  
Vascular Endothelial ◽  
Kinase C

scholarly journals Disturbed flow: p53 SUMOylation in the turnover of endothelial cells

2011 ◽  
Vol 193 (5) ◽  
pp. 805-807 ◽  
Author(s):  
Wakako Takabe ◽  
Noah Alberts-Grill ◽  
Hanjoong Jo
Keyword(s):  
Endothelial Cells ◽  
Blood Flow ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Protein Inhibitor ◽  
Disturbed Flow ◽  
Antiapoptotic Protein ◽  
Kinase C

Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53’s role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it’s binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis.

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