scholarly journals PLC-γ1 is involved in the inflammatory response induced by influenza A virus H1N1 infection

Virology ◽  
2016 ◽  
Vol 496 ◽  
pp. 131-137 ◽  
Author(s):  
Liqian Zhu ◽  
Chen Yuan ◽  
Xiuyan Ding ◽  
Shuai Xu ◽  
Jiayun Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Influenza A Virus ◽  
Influenza A ◽  
Virus H1n1 ◽  
H1n1 Infection

scholarly journals The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection

2011 ◽  
Vol 7 (11) ◽  
pp. e1002341 ◽  
Author(s):  
Toshihiro Ito ◽  
Ronald M. Allen ◽  
William F. Carson ◽  
Matthew Schaller ◽  
Karen A. Cavassani ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Critical Role ◽  
Virus H1n1 ◽  
H1n1 Infection ◽  
Notch Ligand

A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection

The Analyst ◽  
2015 ◽  
Vol 140 (13) ◽  
pp. 4566-4575 ◽  
Author(s):  
Jacky F. C. Loo ◽  
S. S. Wang ◽  
F. Peng ◽  
J. A. He ◽  
L. He ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Human Subjects ◽  
Rnase H ◽  
Virus H1n1 ◽  
H1n1 Infection ◽  
Pcr Assay

A new non-PCR assay platform using RNase H to detect MicroRNA 29a-3p from patients’ throat swabs with influenza A virus H1N1 infection.

scholarly journals The inflammatory response to influenza A virus (H1N1): An experimental and mathematical study

2015 ◽  
Vol 374 ◽  
pp. 83-93 ◽  
Author(s):  
Ian Price ◽  
Ericka D. Mochan-Keef ◽  
David Swigon ◽  
G. Bard Ermentrout ◽  
Sarah Lukens ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Influenza A Virus ◽  
Influenza A ◽  
Virus H1n1 ◽  
Mathematical Study

scholarly journals Symptomatic Predictors for 2009 Influenza A Virus (H1N1) Infection with an Emphasis for Patients with a Negative Rapid Diagnostic Test

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28102 ◽  
Author(s):  
Chen-Yen Kuo ◽  
Yhu-Chering Huang ◽  
Chung-Guei Huang ◽  
Kuo-Chien Tsao ◽  
Tzou-Yien Lin
Keyword(s):  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Influenza A Virus ◽  
Influenza A ◽  
Virus H1n1 ◽  
H1n1 Infection

scholarly journals Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication

2021 ◽  
Author(s):  
Lehao Ren ◽  
Wanju Zhang ◽  
Jing Zhang ◽  
Jiaxiang Zhang ◽  
Huiying Zhang ◽  
...  
Keyword(s):  
Viral Replication ◽  
Influenza A Virus ◽  
Influenza A ◽  
A549 Cells ◽  
Glycolytic Pathway ◽  
Pyruvate Dehydrogenase Kinase ◽  
Metabolic Inhibitors ◽  
Mouse Lung ◽  
Virus H1n1 ◽  
H1n1 Infection

AbstractViruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we observed that influenza A virus (H1N1), a single-stranded, negative-sense RNA virus with an eight-segmented genome, enhanced glycolysis both in mouse lung tissues and in human lung epithelial (A549) cells. In detail, the expression of hexokinase 2 (HK2), the first enzyme in glycolysis, was upregulated in H1N1-infected A549 cells, and the expression of pyruvate kinase M2 (PKM2) and pyruvate dehydrogenase kinase 3 (PDK3) was upregulated in H1N1-infected mouse lung tissues. Pharmacologically inhibiting the glycolytic pathway or targeting hypoxia-inducible factor 1 (HIF-1), the central transcriptional factor critical for glycolysis, significantly reduced H1N1 replication, revealing a requirement for glycolysis during H1N1 infection. In addition, pharmacologically enhancing the glycolytic pathway further promoted H1N1 replication. Furthermore, the change of H1N1 replication upon glycolysis inhibition or enhancement was independent of interferon signaling. Taken together, these findings suggest that influenza A virus induces the glycolytic pathway and thus facilitates efficient viral replication. This study raises the possibility that metabolic inhibitors, such as those that target glycolysis, could be used to treat influenza A virus infection in the future.

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