scholarly journals Activated CD56+ lymphocytes (NK+NKT) mediate immunomodulatory and anti-viral effects during Japanese encephalitis virus infection of dendritic cells in-vitro

Virology ◽  
2012 ◽  
Vol 432 (2) ◽  
pp. 250-260 ◽  
Author(s):  
Harini Sooryanarain ◽  
Vijay Ayachit ◽  
Milind Gore
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Japanese Encephalitis Virus Infection

A tripeptide (NSK) inhibits Japanese encephalitis virus infection in vitro and in vivo

2013 ◽  
Vol 159 (5) ◽  
pp. 1045-1055 ◽  
Author(s):  
Chen Li ◽  
Ling-ling Ge ◽  
Ya-ling Yu ◽  
Li Huang ◽  
Yue Wang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Japanese Encephalitis Virus Infection

scholarly journals Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

2012 ◽  
Vol 158 (2) ◽  
pp. 349-358 ◽  
Author(s):  
Hassan Z. A. Ishag ◽  
Chen Li ◽  
Li Huang ◽  
Ming-xia Sun ◽  
Fengjuan Wang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Japanese Encephalitis Virus Infection

scholarly journals N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo

2008 ◽  
Vol 5 (1) ◽  
pp. 64 ◽  
Author(s):  
Liba Sebastian ◽  
Anita Desai ◽  
Madhusudana N Shampur ◽  
Yogeeswari Perumal ◽  
D Sriram ◽  
...  
Keyword(s):  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Japanese Encephalitis Virus Infection

scholarly journals Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs

2002 ◽  
Vol 83 (8) ◽  
pp. 1897-1905 ◽  
Author(s):  
Chun-Jung Chen ◽  
Shue-Ling Raung ◽  
Ming-Der Kuo ◽  
Yu-Ming Wang
Keyword(s):  
Virus Infection ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Mitogen Activated Protein Kinase ◽  
Therapeutic Effects ◽  
Japanese Encephalitis Virus Infection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Japanese encephalitis virus (JEV) infection generates a rapid inflammatory response including peripheral neutrophil leucocytosis and infiltration of neutrophils into extraneural tissue. The level of inflammation correlates well with the clinical outcome in Japanese encephalitis patients. Non-steroidal anti-inflammatory drugs (NSAIDs), used medicinally for their analgesic and anti-inflammatory properties, are being considered for prevention of cardiovascular disease and cancer, as well as for treatment of human immunodeficiency virus infection. Apart from their ability to inhibit prostaglandin synthesis, the mechanisms underlying the beneficial therapeutic effects are largely unknown. We used aspirin, indomethacin and sodium salicylate to study the role of NSAIDs in JEV propagation in vitro. We found that NSAIDs suppressed JEV propagation in neuronal and non-neuronal cells. Blockade of cyclooxygenase activity by NSAIDs caused decreased production of free radicals and prostaglandins. However, these pharmacological alterations did not seem to correlate well with the antiviral effects. When cells were treated with the mitogen-activated protein kinase (MAPK) inhibitors PD 98059 and SB 203580, salicylate lost its antiviral effect. The activation of MAPK by anisomycin mimicked the action of salicylate in suppressing JEV-induced cytotoxicity. The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate. Our data suggest that the signalling pathways of MAPK play a role in the antiviral action of salicylate.

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