scholarly journals Up-regulation of hepatitis C virus replication by human T cell leukemia virus type I-encoded Tax protein

Virology ◽  
2007 ◽  
Vol 369 (1) ◽  
pp. 198-205 ◽  
Author(s):  
Jing Zhang ◽  
Osamu Yamada ◽  
Kenji Kawagishi ◽  
Hiroshi Yoshida ◽  
Hiromasa Araki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Tax Protein ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein.

1994 ◽  
Vol 68 (5) ◽  
pp. 3374-3379 ◽  
Author(s):  
T Yamada ◽  
S Yamaoka ◽  
T Goto ◽  
M Nakai ◽  
Y Tsujimoto ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Tax Protein ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins

Blood ◽  
1996 ◽  
Vol 87 (8) ◽  
pp. 3410-3417 ◽  
Author(s):  
N Mori ◽  
D Prager
Keyword(s):  
T Cell ◽  
Leukemia Virus ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Tax Protein ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Nf Kappab

Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-1alpha (IL-1alpha). To analyze the mechanisms that lead to the expression of IL-1alpha in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-1alpha promoter involved in activation of the IL-1alpha gene. IL- 1alpha promoter constructs drive transcription of the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells, which constitutively produce IL-1alpha. In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically activated transcription from the IL-1alpha promoter in an uninfected Jurkat cell line. A mutant Tax protein deficient in transactivation of genes by the nuclear factor (NF)-kappaB pathway was unable to induce transcriptional activity of IL-1alpha promoter-CAT constructs, but was rescued by exogenous provision of p65/p50 NF-kappaB. We found that two IL-1alpha kappaB-like sites (positions -1,065 to -1,056 and +646 to +655) specifically formed a complex with NF-kappaB-containing nuclear extract from MT-2 cells and that NF-kappaB bound with higher affinity to the 3′ NF-kappaB binding site than to the 5′ NF-kappaB site. Moreover, deletion of either 5′ or 3′ NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells. These data suggest a general role for Tax induction of IL-1alpha gene transcription by the NF-kappaB pathway. Expression of IL-1alpha by HTLV-I productively infected cells may be important in the hypercalcemia, osteolytic bone lesions, neutrophilia, elevation of C-reactive protein, and fever frequently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.

Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells

2002 ◽  
Vol 99 (3) ◽  
pp. 378-385 ◽  
Author(s):  
Naoki Mori ◽  
Masahiro Fujii ◽  
Michael Hinz ◽  
Katsushi Nakayama ◽  
Yasuaki Yamada ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cyclin D1 ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Tax Protein ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line

1998 ◽  
Vol 273 (36) ◽  
pp. 23598-23604 ◽  
Author(s):  
Isabelle Lemasson ◽  
Sabine Thébault ◽  
Claude Sardet ◽  
Christian Devaux ◽  
Jean-Michel Mesnard
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Virus Type ◽  
Leukemia Virus ◽  
Type I ◽  
Cell Leukemia ◽  
Cell Leukemia Virus Type ◽  
Tax Protein ◽  
Human T Cell ◽  
T Cell Leukemia Virus
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