scholarly journals Critical role of Arg59 in the high-affinity gp120-binding region of CD4 for human immunodeficiency virus type 1 infection

Virology ◽  
2007 ◽  
Vol 363 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Danielle Fontenot ◽  
Jason K. Jones ◽  
Mohammad M. Hossain ◽  
Pramod N. Nehete ◽  
Eric M. Vela ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Critical Role ◽  
Binding Region ◽  
High Affinity ◽  
Gp120 Binding ◽  
Immunodeficiency Virus

scholarly journals Human immunodeficiency virus type 1 Vpr: functions and molecular interactions

2009 ◽  
Vol 90 (8) ◽  
pp. 1795-1805 ◽  
Author(s):  
Bizhan Romani ◽  
Susan Engelbrecht
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Critical Role ◽  
Cellular Proteins ◽  
Immunodeficiency Virus ◽  
Infected Cells ◽  
Hiv 1

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of cellular and viral proteins. The functions of many of these interactions in the pathogenesis of HIV-1 have been identified. Deletion of the vpr gene reduces the virulence of HIV-1 dramatically, indicating the importance of this protein for the virus. This review describes the current findings on several established functions of HIV-1 Vpr and some possible roles proposed for this protein. Because Vpr exploits cellular proteins and pathways to influence the biology of HIV-1, understanding the functions of Vpr usually involves the study of cellular pathways. Several functions of Vpr are attributed to the virion-incorporated protein, but some of them are attributed to the expression of Vpr in HIV-1-infected cells. The structure of Vpr may be key to understanding the variety of its interactions. Due to the critical role of Vpr in HIV-1 pathogenicity, study of the interactions between Vpr and cellular proteins may help us to understand the mechanism(s) of HIV-1 pathogenicity.

scholarly journals A Critical Role of Nitric Oxide in Human Immunodeficiency Virus Type 1-Induced Hyperresponsiveness of Cultured Monocytes

1996 ◽  
Vol 2 (4) ◽  
pp. 460-468 ◽  
Author(s):  
Michael Bukrinsky ◽  
Helena Schmidtmayerova ◽  
Gabriele Zybarth ◽  
Larisa Dubrovsky ◽  
Barbara Sherry ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Critical Role ◽  
Immunodeficiency Virus

scholarly journals Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.

1997 ◽  
Vol 71 (2) ◽  
pp. 1476-1484 ◽  
Author(s):  
J H Simon ◽  
P Stumbles ◽  
N Signoret ◽  
C Somoza ◽  
M Puklavec ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Binding Site ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Gp120 Binding ◽  
Immunodeficiency Virus

scholarly journals A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.

1993 ◽  
Vol 177 (4) ◽  
pp. 949-954 ◽  
Author(s):  
J H Simon ◽  
C Somoza ◽  
G A Schockmel ◽  
M Collin ◽  
S J Davis ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Syncytium Formation ◽  
Gp120 Binding ◽  
Ability To Act ◽  
Immunodeficiency Virus ◽  
Inhibitory Antibodies ◽  
Hiv 1

CD4 is the primary receptor for the human immunodeficiency virus type 1 (HIV-1). Early mutational studies implicated a number of residues of CD4, centered in the region 41-59, in binding to gp120. However, further mutational analyses, together with studies using inhibitory antibodies or CD4-derived peptides, have suggested that other regions of CD4 are also involved in binding or postbinding events during infection. To resolve these ambiguities, we used rat CD4 mutants in which particular regions were replaced with the corresponding sequence of human CD4. We have previously shown that some of these are able to bind HIV-1 gp120, and here we test their ability to act as functional receptors. We find that the presence of human CD4 residues 33-62 is enough to confer efficient receptor function to rat CD4, and we conclude that it is unlikely that regions of CD4 outside this sequence are involved in specific interactions with HIV-1 during either infection or syncytium formation.

scholarly journals Structure–functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication

Virology ◽  
2004 ◽  
Vol 328 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Dineshkumar Thotala ◽  
Elizabeth A. Schafer ◽  
Biswanath Majumder ◽  
Michelle L. Janket ◽  
Marc Wagner ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Human Immunodeficiency Virus ◽  
Virus Replication ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
Hiv 1

scholarly journals Role of Cell Surface Glycosaminoglycans of Human T Cells in Human Immunodeficiency Virus Type-1 (HIV-1) Infection

1996 ◽  
Vol 40 (11) ◽  
pp. 827-835 ◽  
Author(s):  
Yukako Ohshiro ◽  
Tsutomu Murakami ◽  
Kazuhiro Matsuda ◽  
Kiyoshi Nishioka ◽  
Keiichi Yoshida ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Cell Surface ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human T Cells ◽  
Immunodeficiency Virus ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document