scholarly journals CD1d expression on hemopoietic cells promotes CD4+ Th1 response in coxsackievirus B3 induced myocarditis

Virology ◽  
2006 ◽  
Vol 352 (1) ◽  
pp. 226-236 ◽  
Author(s):  
S.A. Huber
Keyword(s):  
Coxsackievirus B3 ◽  
Th1 Response ◽  
Hemopoietic Cells

Replicase gene of coxsackievirus B3.

1984 ◽  
Vol 51 (3) ◽  
pp. 742-746 ◽  
Author(s):  
P O Stålhandske ◽  
M Lindberg ◽  
U Pettersson
Keyword(s):  
Coxsackievirus B3 ◽  
Replicase Gene

scholarly journals Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

Cell Systems ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 304-323.e13
Author(s):  
Aaron B. Lopacinski ◽  
Andrew J. Sweatt ◽  
Christian M. Smolko ◽  
Elise Gray-Gaillard ◽  
Cheryl A. Borgman ◽  
...  
Keyword(s):  
Host Cell ◽  
Coxsackievirus B3 ◽  
Kinetics Of

scholarly journals Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3678
Author(s):  
Olga V. Andreeva ◽  
Bulat F. Garifullin ◽  
Vladimir V. Zarubaev ◽  
Alexander V. Slita ◽  
Iana L. Yesaulkova ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Theoretical Calculations ◽  
Nucleoside Analogs ◽  
Coxsackievirus B3 ◽  
Nucleoside Analogues ◽  
Moderate Activity ◽  
Coat Proteins ◽  
Influenza Virus A ◽  
Ic50 Values

A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione, alloxazine) or to the C-5 and N-3 atoms of the 6-methyluracil moiety was synthesized. All compounds synthesized were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1) and coxsackievirus B3. Antiviral assays revealed three compounds, 2i, 5i, 11c, which showed moderate activity against influenza virus A H1N1 with IC50 values of 57.5 µM, 24.3 µM, and 29.2 µM, respectively. In the first two nucleoside analogues, 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via butylene linkers to N-1 and N-3 atoms of the heterocycle moiety (6-methyluracil and alloxazine, respectively). In nucleoside analogue 11c, two 1,2,3-triazol-4-yl-2′,3′,5′-tri-O-acetyl-β-d-ribofuranose fragments are attached via propylene linkers to the C-5 and N-3 atoms of the 6-methyluracil moiety. Almost all synthesized 1,2,3-triazolyl nucleoside analogues showed no antiviral activity against the coxsackie B3 virus. Two exceptions are 1,2,3-triazolyl nucleoside analogs 2f and 5f, in which 1,2,3-triazol-4-yl-2′,3′,5′-tri-O-acetyl-β-d-ribofuranose fragments are attached to the C-5 and N-3 atoms of the heterocycle moiety (6-methyluracil and alloxazine respectively). These compounds exhibited high antiviral potency against the coxsackie B3 virus with IC50 values of 12.4 and 11.3 µM, respectively, although both were inactive against influenza virus A H1N1. According to theoretical calculations, the antiviral activity of the 1,2,3-triazolyl nucleoside analogues 2i, 5i, and 11c against the H1N1 (A/PR/8/34) influenza virus can be explained by their influence on the functioning of the polymerase acidic protein (PA) of RNA-dependent RNA polymerase (RdRp). As to the antiviral activity of nucleoside analogs 2f and 5f against coxsackievirus B3, it can be explained by their interaction with the coat proteins VP1 and VP2.

scholarly journals IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

2002 ◽  
Vol 169 (7) ◽  
pp. 3600-3605 ◽  
Author(s):  
Mari Strengell ◽  
Timo Sareneva ◽  
Don Foster ◽  
Ilkka Julkunen ◽  
Sampsa Matikainen
Keyword(s):  
Innate Immunity ◽  
Th1 Response ◽  
Expression Of Genes

MicroRNA-203 enhances Coxsackievirus B3 replication through targeting zinc finger protein-148

2012 ◽  
Vol 70 (2) ◽  
pp. 277-291 ◽  
Author(s):  
Maged Gomaa Hemida ◽  
Xin Ye ◽  
Huifang M. Zhang ◽  
Paul J. Hanson ◽  
Zhen Liu ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Coxsackievirus B3 ◽  
Finger Protein
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