scholarly journals Vibrational spectroscopy as a tool for studying drug-cell interaction: Could high throughput vibrational spectroscopic screening improve drug development?

2017 ◽  
Vol 91 ◽  
pp. 16-30 ◽  
Author(s):  
Lauren E. Jamieson ◽  
Hugh J. Byrne
Keyword(s):  
Drug Development ◽  
Vibrational Spectroscopy ◽  
High Throughput ◽  
Cell Interaction

scholarly journals High-Throughput Screening and Drug Development to Fix RyR Pathology

2021 ◽  
Vol 120 (3) ◽  
pp. 148a-149a
Author(s):  
Robyn T. Rebbeck ◽  
Kaja Rozman ◽  
Gabrielle M. Evans ◽  
Jacob Schwarz ◽  
Marzena Baran ◽  
...  
Keyword(s):  
Drug Development ◽  
High Throughput ◽  
High Throughput Screening

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss

2015 ◽  
Vol 166 (5) ◽  
pp. 440-450 ◽  
Author(s):  
Maki Niihori ◽  
Terry Platto ◽  
Suzu Igarashi ◽  
Audriana Hurbon ◽  
Allison M. Dunn ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Development ◽  
Hair Cell ◽  
High Throughput ◽  
Cell Damage ◽  
Swimming Behavior ◽  
Development Platform ◽  
Hair Cell Damage

scholarly journals Discovery Methodology of Novel Conotoxins from Conus Species

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 417 ◽  
Author(s):  
Ying Fu ◽  
Cheng Li ◽  
Shuai Dong ◽  
Yong Wu ◽  
Dongting Zhangsun ◽  
...  
Keyword(s):  
Drug Development ◽  
Gene Cloning ◽  
High Throughput ◽  
Disulfide Bond ◽  
Cone Snail ◽  
Crude Venom ◽  
Drug Candidates ◽  
Conus Species ◽  
New Drug Development ◽  
Natural Peptides

Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but less than 0.1% of the estimated conotoxins has been characterized to date. Hence, the discovery of novel conotoxins from the huge conotoxin resources with high-throughput and sensitive methods becomes a crucial key for the conotoxin-based drug development. In this review, we introduce the discovery methodology of new conotoxins from various Conus species. It focuses on obtaining full N- to C-terminal sequences, regardless of disulfide bond connectivity through crude venom purification, conotoxin precusor gene cloning, venom duct transcriptomics, venom proteomics and multi-omic methods. The protocols, advantages, disadvantages, and developments of different approaches during the last decade are summarized and the promising prospects are discussed as well.

High-Throughput Toxicity Testing in Drug Development: Aims, Strategies, and Novel Trends

2013 ◽  
pp. 33-75 ◽  
Author(s):  
Willem G.E.J. Schoonen ◽  
Walter M.A. Westerink ◽  
Femke M. van de Water ◽  
Horbach G. Jean
Keyword(s):  
Drug Development ◽  
High Throughput ◽  
Toxicity Testing

High-throughput methods for screening liposome–macrophage cell interaction

2014 ◽  
Vol 25 (3) ◽  
pp. 211-221 ◽  
Author(s):  
Ciara Kelly ◽  
Ciaran Lawlor ◽  
Colin Burke ◽  
James W. Barlow ◽  
Joanne M. Ramsey ◽  
...  
Keyword(s):  
High Throughput ◽  
Cell Interaction ◽  
Macrophage Cell

scholarly journals A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development

2011 ◽  
Vol 203 (10) ◽  
pp. 1445-1453 ◽  
Author(s):  
Kathrin Buchholz ◽  
Thomas A. Burke ◽  
Kim C. Williamson ◽  
Roger C. Wiegand ◽  
Dyann F. Wirth ◽  
...  
Keyword(s):  
Drug Development ◽  
Malaria Transmission ◽  
High Throughput ◽  
High Throughput Screen

scholarly journals A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development

2008 ◽  
Vol 5 (1) ◽  
pp. 23 ◽  
Author(s):  
Kevin S Jones ◽  
Alexander P Alimov ◽  
Horacio L Rilo ◽  
Ronald J Jandacek ◽  
Laura A Woollett ◽  
...  
Keyword(s):  
Drug Development ◽  
Small Molecules ◽  
High Throughput ◽  
Fat Metabolism ◽  
Or Genes
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